Comparative effectiveness of different eradication schemes in the treatment of peptic ulcer disease associated with Helicobacter pylori

Aim of investigation: comparative analysis of 10 schemes of eradication in patients with duodenal ulcer associated with Helicobacter pylori. Materials and methods: 10 eradication schemes were investigated at the Department of Gastroenterology for 15 years (Central state medical academy of department of presidential affairs, Head of the Department Minushkin O. N.) 297 patients with duodenal ulcer associated with Helicobacter pylori were divided in treatment groups, as follows: 30 patients received triple therapy with omeprazol (O), clarithromycin (C) and metronidazole (M); 98 patients received triple therapy with omeprasol (O), clarithromycin (C) and amoxicillin (A): the dose of clarithromycin and the duration of treatment (5-day, 7-day, 10-day) was selected depending on the degree of Hp contamination (+, ++, +++); 68 patients received sequential therapy with omeprazol (O), clarithromycin (C) and amoxicillin (A); 117 patients received triple therapy with omeprazol (O), clarithromycin (C) and furazolidon (F) and tinidazol (T) - 57 patients or with omeprazol (O), wilprafen (W) and levofloxacin (L) and amoxicillin (A) - 60 patients; and 50 elderly patients received half doses of O+C+A combnation or pantoprazol (P), dazolic (D) and amoxicillin (A). Esophagogastroduodenoscopy (EGS), Giemsa stain in biopsy and rapid urease test (RUT) were used to evaluate the quality of ulcer healing and efficacy of eradication. Student`s t-criterion and Fisher`s method were used in statistical processing (Significant differences in significance level of 95%, p<0,05) Results: O+C+M scheme had the lowest efficacy (60%). 6 of 10 schemes were effective: O+C+A - 80%; sequential scheme - 83% (with (F) - 93%, with (T) - 88%; with (W) 90% or (L) 80%). Discussion: Eradication efficacy increased by 97% with day-degree contamination selection. In elderly patients half doses schemes were effective (O+C+A - 87% and P+D+A 90%).

ЯБДК, схемы эрадикации НР-инфекции, омепразол, кларитромицин, амоксицилин, вильпрофен, левофлаксоцин, пантопразол, дазолик, duodenal ulcer, eradication schemes, omeprazol, clarithromycin, amoxicillin, wilprofen, levofloxacin, pantoprazol, dazolic