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Experimental and Clinical Gastroenterology

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The role of HLA-DQ2.2 genotype for patients with celiacia

Abstract

The aim of this study was to observe the role of the genotype DQ 2.2 in patients with celiac disease (CD): serological and morphological features of celiac disease in patients with the DQ2.2 genotype Materials and methods: We examined 47 patients with СD, diagnosed according to ESPHGAN criteria. All participants were tested for antibodies to tissue transglutaminase-2 (TTG) and deamidated gliadin peptides, morphometric examination of biopsy specimens of duodenal mucosa and genotyping were carried out. Based on the results of genotyping, patients were divided into 2 groups: group 1 comprised 18 patients with the genotype DQ2.2; group of 2-29 patients with other genotypes of CD. Results: an increase of anti-TTG antibodies was observed in all patients in group 1. Moreover, a moderate increase in group 1 was 55.6%, and in the 2nd group, 27.6% (p = 0.07). A significant increase of anti-TTG in group 1-44.4%, in the 2 group - 3.4% (p = 0.001). In addition, the morphological changes of the duodenal mucosa corresponding to the level of Marsh 3b were more often observed in group 1-27.8% than in 2-0% (p = 0.006). Morphometric parameters of duodenal mucosa in group 1 reveal more severe atrophic changes. Conclusion: it is expected that the detection of the genotype DQ2.2 can serve as a predictor of severe serological (a significant increase of anti-TTG antibodies level) and morphological changes in CD.

About the Authors

N. S. Shapovalova
St. Petersburg State Pediatric Medical University
Russian Federation


V. P. Novikova
St. Petersburg State Pediatric Medical University
Russian Federation


M. O. Revnova
St. Petersburg State Pediatric Medical University
Russian Federation


S. V. Lapin
I. P. Pavlov State Medical University First St. Petersburg State Medical University
Russian Federation


I. V. Kholopova
I. P. Pavlov State Medical University First St. Petersburg State Medical University
Russian Federation


A. I. Khavkin
Yu.E Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University
Russian Federation


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For citations:


Shapovalova N.S., Novikova V.P., Revnova M.O., Lapin S.V., Kholopova I.V., Khavkin A.I. The role of HLA-DQ2.2 genotype for patients with celiacia. Experimental and Clinical Gastroenterology. 2018;(11):19-23. (In Russ.)

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ISSN 1682-8658 (Print)