MOTOR FUNCTION OF THE INTESTINE IN IRRITABLE BOWEL SYNDROME WITH CONSTIPATION

Abstract

Irritable bowel syndrome (IBS) is a functional bowel disease in which recurrent abdominal pain is associated with defecation or a change in bowel function. Despite the numerous works devoted to the study of mechanisms of IBS development, intestinal motility in this disease has not been studied enough. The goal is to identify features of the motor function of the colon and small intestine in irritable bowel syndrome with constipation (IBS-C) and dolichosigma. Material and methods. The method of electromyography was used to study 84 patients with IBS-C in comparison with a group of 25 patients with dolichosigma and a group of 35 patients with functional constipation. The frequency of slow waves of the small and large intestine (patients with functional constipation) and left colon (patients with IBS-C and dolichosigma) was measured by the hardware-software complex “Conan-M”. Results and discussion. In electromyography patients with IBS-C showed a decrease in the frequency of slow waves to 5.4±0.2 V min (10%, p<0.05), the amplitude - to 0.09±0001 mV (46.6% p<0.05). The increase of spike activity was revealed: frequency 2.8±0.18 (40% p<0.05)., amplitude-0.13±0.02 mV (13.4% p<0.05). In patients with dolichosigma on electromyography revealed a decrease in the frequency of slow waves to 4.8±0.15 per minute (20%, p<0.05), the amplitude - to 0.07±0011 mV (53.3% p<0.05) with minimal spike activity. IBS-W is characterized by hypomotor dyskinesia of the left parts with pronounced spastic contractions of the smooth muscles of the circular layer of the intestine due to, perhaps, the activity of stimulating serotoninergic effects on the spastic activity of the circular muscle layer or inhibitory adrenergic neurons of the intermuscular (auerbachian) nerve plexus. When dolichosigma identified hypomotor dyskinesia of the left departments of the colon due to stretching of the mechanoreceptors in the afferent neurons of the intramural reflex arcs.