ULCERATIVE COLITIS TREATMENT EFFICIENCY ASSESSED BY ULTRASONOGRAPHY WITH CONTRAST ENHANCEMENT
Abstract
Aim of investigation: determination and selection of parameters of ultrasonography with contrast enhancement for evaluation of the effectiveness of the therapy in patients with ulcerative colitis (UC). Materials and methods: The study included 20 patients with active left-side UC or pancolitis. Before the treatment all patients underwent colonoscopy and ultrasonography in standard regimen and with contrast enhancement. All patients received systemic 5-aminosalicylic acid in granules at a dose of 4 g per day for 3 months. After treatment, patients were repeatedly underwent endoscopy and ultrasound. Based on the ultrasound obtained with a contrast enhancement curve, the contrast parameters were automatically calculated: the maximum intensity (Imax), the area under the contrast curve (AUC), rise time (RT), peak time (TTP) and mean transit time (mTT), time to half-wash (HTWo). Results: According to the results of the examination of patients before and after three months of treatment, it was established that the most informative US-parameter for assessing the activity of inflammation is the AUC. For this parameter, a positive correlation with the endoscopic activity of the UC was obtained. Conclusion: Ultrasonography with contrast enhancement may be a good alternative non-invasive method for assessing the efficacy of conservative therapy in patients with UC, but it is necessary to continue the study on a larger sample to identify the relationship between the other parameters and validate this technique.
About the Authors
I. L. Khalif
FSBI «A. N. Ryzhykh State scientific center of coloproctology» of Ministry of health of Russian Federation
Russian Federation
Russian Federation
M. V. Shapina
FSBI «A. N. Ryzhykh State scientific center of coloproctology» of Ministry of health of Russian Federation
Russian Federation
Russian Federation
L. P. Orlova
FSBI «A. N. Ryzhykh State scientific center of coloproctology» of Ministry of health of Russian Federation
Russian Federation
Russian Federation
P. G. Evgrafov
FSBI «A. N. Ryzhykh State scientific center of coloproctology» of Ministry of health of Russian Federation
Russian Federation
Russian Federation
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Review
For citations:
Khalif I.L., Shapina M.V., Orlova L.P., Evgrafov P.G. ULCERATIVE COLITIS TREATMENT EFFICIENCY ASSESSED BY ULTRASONOGRAPHY WITH CONTRAST ENHANCEMENT. Experimental and Clinical Gastroenterology. 2018;(5):32-37. (In Russ.)
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