On the issue of lipid metabolism and the validity of atherogenic indices in the assessment and prevention of negative consequences of normobaric hypoxia

Lipid metabolism disorders play a critical role in the initiation, development and progression of a number of socially significant diseases, including obesity, atherosclerosis, ischemic diseases, diabetes mellitus, liver dysfunction, metabolic syndrome and its consequences. Acute normobaric hypoxia, as an exogenous condition that occurs when the partial pressure of oxygen decreases at normal barometric pressure, is one of the hypoxia models used in animal studies. The aim of the research was to study changes in lipid metabolism and the concentration of phospholipid fractions in the blood serum of rats exposed to acute normobaric hypoxia, as well as to evaluate atherogenic indices and the prospects for using natural antihypoxants for the prevention and correction of hypoxic disorders. The results of the study showed that simulated hypoxia causes significant disturbances in lipid metabolism in rats, including a decrease in serum concentrations of phosphatidylcholine, phosphatidylserine, sphingomyelin and antiatherogenic high-density lipoproteins, as well as an increase in the levels of low-density lipoproteins, triglycerides, total cholesterol and valid lipid metabolism (atherogenic) indices. The noted changes can be considered as a pronounced adaptive-compensatory response of the body, which can lead to disturbances in the barrier and transport function of biological membranes. The experiment found that the use of plant antihypoxants contributes to partial compensation for the negative consequences, which confirms their potential for correcting metabolic shifts induced by hypoxia in the areas of improvement and development of biohacking technologies aimed at increasing the duration and quality of life.

hypoxia, lipid metabolism, atherogenic indices, lipopolysaccharides, metabolic syndrome, antihypoxants

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