Maternal history in preterm newborns: pathogenetic features and nosological structure

Of particular clinical importance at present is a detailed study of perinatal history, since the pathological obstetric-gynecological, infectious and somatic status of the mother causes dysfunctions in the fetoplacental complex, increases the risk of premature birth, disrupts the vital functions of the fetus and reduces the reserve capabilities of all organ systems in the newborn. Purpose. Analyze obstetric-gynecological, infectious and somatic status of mothers in premature babies, to optimize postnatal observation tactics. Materials and methods. The study included 60 children born prematurely with the determination of the features of obstetric-gynecological, infectious and somatic history of their mothers by retrospective analysis. Depending on gestational age (GV), children were divided into 3 groups: 1 group - GV 34.1-36.9 weeks (20 children); Group 2 - GV 30.1-34 weeks (21 children); Group 3 - GV 26-30 weeks (19 children). Results. The most pronounced burden of obstetric-gynecological and somatic history occurred in mothers in the 2nd and 3rd groups, where the birth of premature babies was significantly more common (23.8%; 31.6%) and abortion (28.6%; 57.9%) in the history. Antenatal fetal death occurred only in mothers in the 2nd and 3rd groups (4.8%; 10,5%). The maximum burden for inflammatory diseases of the sexual sphere occurred in the 3rd group. Infectious pathology of other organ systems, represented by acute gestational or chronic pyelonephritis in the stage of exacerbation, tonsillitis, bronchitis, was significantly more common in patients in the 3rd group (52.6%, 47.4%, 21.1%). Operative delivery in the study groups was quite frequent: 45% in group 1, 47.6% in group 2, 31.6% in group 3, in general - 41.7% of the total number of mothers (including 16% indication for caesarean section had premature placental detachment). Conclusion. Thus, the study of perinatal history revealed the presence of a wide range of pathological factors that aggressively act on the fetus, having both a direct damaging effect on the tissue and disrupting the functional activity of various organ systems.

prematurity, maternal history, obstetric-gynecological history, fetoplacental insufficiency, infectious pathology

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