The effectiveness of autoprobiotics in the correction of lipid metabolism

Objective: evaluation of the effectiveness of an autoprobiotic based on indigenous enterococci in the correction of lipid metabolism disorders. Materials and Methods: 17 patients with metabolic syndrome and dyslipidemia were under observation. All patients signed an informed consent prior to the start of the study procedures. An autoprobiotic (AP) based on indigenous enterococci was prescribed as a personalized functional food product (PFPP). AP was prescribed 50 ml 2 times a day for 20 days, 2 courses were used with an interval of 1 month. The effectiveness of AP was assessed by changes in lipid metabolism at two time points: V1 (before the start of treatment), V2 (2 weeks after the end of the second course of autoprobiotic therapy). Lipid profile indicators: total cholesterol (CL), low-density lipoproteins (LDL), high-density lipoproteins (HDL), triglycerides (TG) were evaluated in fasting blood serum in dynamics before treatment and two weeks after the end of the second course of autoprobiotics. At the same time points, the level of C-reactive protein (CRP) was additionally assessed as a marker of chronic low-level inflammation, which can aggravate lipid profile disorders in patients with metabolic syndrome. Statistical processing was carried out using the SPSS8.0 computer software package. Results: After taking the autoprobiotic, a statistically significant improvement was revealed in most of the analyzed parameters of lipid metabolism, as well as a decrease in the level of C-reactive protein. (p<0.05). Conclusions: autoprobiotics can be a promising method of correcting disorders not only of the intestinal microbiota, but also changes in lipid metabolism. It seems relevant to use a combination of autoprobiotics with statins, because this will provide an impact on different pathogenetic pathways of dyslipidemia. However, further research is needed to gain a deeper understanding of the underlying mechanisms of the identified effect.

obesity, autoprobiotics, cholesterol, lipids, microbiota

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