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STAGING SYSTEMS OF HEPATOCELLULAR CARCINOMA

Abstract

It is the data of literature on existing classifications and systems of assessment and prognosis of hepatocellular carcinoma (HCC). In some classifications takes into account only the characteristics of the tumor tissue, in others are used biochemical and clinical characteristics in addition. Some systems allow to predict the survival of patients regardless of the stage of the disease, while others are most effective for the individual stages. The international TNM classification is generally accepted for the development of treatment methods and determining the forecast mainly for resectable HCC forms. The Japanese staging system (JIS) is mainly recommended for operable patients. Italian scale (CLIP), on the contrary, is intended to analyze HCC, which is not subject to surgical treatment. The Barcelona classification of liver cancer (BCLC) is considered the most universal, because it takes into account the stage of disease, the condition of the liver parenchyma and does not depend on the method of treatment and the patient’s place of residence. Therefore, the choice of staging system and assessment of disease prognosis should be based on the clinical and morphological features of the disease, taking into account features of application of various scales.

About the Authors

U. N. Tumanova
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology Russian Ministry of Healthcare
Russian Federation


A. I. Shchegolev
Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology Russian Ministry of Healthcare
Russian Federation


References

1. El-Serag H. B., Rudolph K. L. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis // Gastroenterology. 2007; 132: 2557-2576.

2. Jemal A., Bray F., Center M. M. et al. Global cancer statistics // CA Cancer J. Clin. 2011; 61: 69-90.

3. Щеголев А. И., Мишнев О. Д., Тинькова И. О. Онкоморфология печени. М.: Издательство РГМУ, 2006. 252 с.

4. El-Serag H. B. Epidemiology of hepatocellular carcinoma // Clin. Liv. Dis. 2001; 5: 87-107.

5. Состояние онкологической помощи населению России в 2014 году / Под ред. А. Д. Каприна, В. В. Старинского, Г. В. Петровой. М.: МНИОИ им. П. А. Герцена - филиал ФГБУ «НМИРЦ» Минздрава России, 2015. 236 с.

6. International Union Against Cancer (UICC). TNM Classification of Malignant Tumours, 7th ed. / Eds. L. H. Sobin, M. K. Gospodarowicz, Ch. Wittekind. New York: Wiley-Blackwell; 2009.

7. Chevret S., Trinchet J. C., Mathieu D. et al. A new prognostic classification for predicting survival in patients with hepatocellular carcinoma // J. Hepatol. 1999; 3: 133-141.

8. Llovet J. M., Bru C., Bruix J. Prognosis of hepatocellular carcinoma: the BCLC staging classification // Semin. Liver Dis. 1999; 19: 329-338.

9. Llovet J. M., Bruix J. Prospective validation of the Cancer of the Liver Italian Program (CLIP) score: a new prognostic system for patients with cirrhosis and hepatocellular carcinoma // Hepatology. 2000; 32: 679-680.

10. Okuda K., Ohtsuki T., Obata H. et al. Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Study of 850 patients // Cancer. 1985; 56: 918-928.

11. Chung H., Kudo M., Takahashi S. et al. Comparison of three current staging systems for hepatocellular carcinoma: Japan integrated staging score, new Barcelona Clinic Liver Cancer staging classification, and Tokyo score // J. Gastroenterol. Hepatol. 2008; 23: 445-452.

12. Tateishi R., Yoshida H., Shiina S. et al. Proposal of a new prognostic model for hepatocellular carcinoma: an analysis of 403 patients // Gut. 2005; 54: 419-425.

13. Chan S. L., Mo F. K., Johnson P. J. et al. Prospective validation of the Chinese University Prognostic Index and comparison with other staging systems for hepatocellular carcinoma in an Asian population // J. Gastroenterol. Hepatol. 2011; 26: 340-347.

14. Edmondson H. A., Steiner P. E. Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies // Cancer. 1954; 7: 462-504.

15. American College of Radiology. Quality and safety resources: Liver Imaging-Reporting and Data System. Available at: http://www.acr.org/Quality- Safety/Resources/LIRADS. Accessed April 22, 2012

16. Туманова У. Н., Кармазановский Г. Г., Щеголев А. И. Система LI-RADS при компьютерно-томографической диагностике гепатоцеллюлярного рака // Медицинская визуализация. 2014; 6: 44-50.

17. Matsui O., Kobayashi S., Sanada J. et al. Hepatocelluar nodules in liver cirrhosis: hemodynamic evaluation (angiography-assisted CT) with special reference to multi-step hepatocarcinogenesis // Abdom Imaging. 2011; 36: 264-272.

18. Туманова У. Н., Дубова Е. А., Кармазановский Г. Г., Щеголев А. И. Компьютерная томография в оценке кровоснабжения гепатоцеллюлярного рака. Анналы хирургической гепатологии. 2013; 4: 53-60.

19. Shchyogolev A. I., Dubova E. A., Tumanova U. N. Vascularization of hepatocellular carcinoma tissue depends on its differentiation degree // Bulletin of Experimental Biology and Medicine. 2012; 153: 490-494.

20. Туманова У. Н., Дубова Е. А., Кармазановский Г. Г., Щеголев А. И. Компьютерно-томографические и морфологические сопоставления при гепатоцеллюлярном раке различной степени дифференцировки // Молекулярная медицина. 2012; 5: 35-40.

21. Okuda K., Obata H., Nakajima Y. et al. Prognosis of primary hepatocellular carcinoma // Hepatology. 1984; 4: 3-6.

22. Shouval D. HCC: what’s the score? // Gut. 2002; 50: 749-750.

23. A new prognostic system for hepatocellular carcinoma: a retrospective study of 435 patients: the Cancer of the Liver Italian Program (CLIP) investigators // Hepatology. 1998; 28: 751-755.

24. Prospective validation of the CLIP score: a new prognostic system for patients with cirrhosis and hepatocellular carcinoma. The Cancer of the Liver Italian Program (CLIP) Investigators // Hepatology. 2000; 31: 840-845.

25. Subramaniam S., Kelley R. K., Venook Ap. A review of hepatocellular carcinoma (HCC) staging systems // Chin. Clin. Oncol. 2013; 2: 33 Available from: www.thecco.net/article/view/2528

26. Marrero J. A., Kudo M., Bronowicki J. P. The challenge of prognosis and staging for hepatocellular carcinoma // Oncologist. 2010; 15 (Suppl. 4): 23-33.

27. Llovet J. M., Bustamante J., Castells A. et al. Prospective followup of untreated hepatocellular carcinoma: rationale for the design and evaluation of therapeutic trials // Hepatology. 1999; 29: 62-67.

28. Llovet J. M., Burroughs A., Bruix J. Hepatocellular carcinoma // Lancet. 2003; 362: 1907-1917.

29. Llovet J. M., Di Bisceglie A. M., Bruix J. et al. Design and endpoints of clinical trials in hepatocellular carcinoma // J. Natl. Cancer Inst. 2008; 100: 698-711.

30. Bruix J., Sherman M. Management of hepatocellular carcinoma: an update // Hepatology. 2011; 53: 1020-1022.

31. European Association For The Study Of The Liver, European Organisation For Research And Treatment Of Cancer. EASLEORTC clinical practice guidelines: management of hepatocellular carcinoma // J. Hepatol. 2012; 56: 908-943.

32. Bolondi L., Burroughs A., Dufour J. F. et al. Heterogeneity of patients with intermediate (BCLC B) Hepatocellular Carcinoma: proposal for a subclassification to facilitate treatment decisions // Semin. Liver Dis. 2012; 32: 348-359.

33. Dufour J. F., Bargellini I., De Maria N. et al. Intermediate hepatocellular carcinoma: current treatments and future perspectives // Ann. Oncol. 2013; 24 (Suppl 2): ii24-ii29.

34. Sorensen J. B., Klee M., Palshof T. Performance status assessment in cancer patients. An inter-observer variability study // Br. J. Cancer. 1993; 67: 773-775.

35. Kudo M., Chung H., Osaki Y. Prognostic staging system for hepatocellular carcinoma (CLIP score): its value and limitations, and a proposal for a new staging system, the Japan Integrated Staging Score (JIS score) // J. Gastroenterol. 2003; 38: 207-215.

36. Kudo M., Chung H., Haji S. et al. Validation of a new prognostic staging system for hepatocellular carcinoma: the JIS score compared with the CLIP score // Hepatology. 2004; 40: 1396-1405.

37. Toyoda H., Kumada T., Kiriyama S. et al. Comparison of the usefulness of three staging systems for hepatocellular carcinoma (CLIP, BCLC, and JIS) in Japan // Am. J. Gastroenterol. 2005; 100: 1764-1771.

38. Leung T. W. T., Tang A. M. Y., Zee B. et al. Construction of the Chinese University Prognostic Index for hepatocellular carcinoma and comparison with the TNM staging system, the Okuda staging system, and the cancer of the liver Italian program staging system // Cancer. 2002; 94: 1760-1769.


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For citations:


Tumanova U.N., Shchegolev A.I. STAGING SYSTEMS OF HEPATOCELLULAR CARCINOMA. Experimental and Clinical Gastroenterology. 2016;(7):121-128. (In Russ.)

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