GENETIC PREDISPOSITION TO DEVELOPMENT OF TOXIC HEPATITIS
Abstract
The aim of this study was to investigate the frequency of polymorphic variants of genes CYP2E1 and GSTA1 in patients with pathology of the hepatobiliary system (PHS) and healthy individuals in the Republic of Bashkortostan, as well as an analysis of possible associations of genotypes of this gene with the development of PHS. Materials and methods: There were examined 81 patients with pathology of the hepatobiliary system. Was studied association analysis of polymorphic loci of genes CYP2E1 and GSTA1. Results: The study demonstrated that a marker of risk of developing the disease is AA genotype (OR = 2,09; 95% CI 1,07-4,10) polymorphic locus gene rs3957357 GSTA1.
About the Authors
T. G. Kutlina
Federal Budget Institution of Science «Ufa Research Institute of Occupational Health and Human Ecology»
Russian Federation
Russian Federation
R. R. Galimova
Federal Budget Institution of Science «Ufa Research Institute of Occupational Health and Human Ecology»
Russian Federation
Russian Federation
M. M. Shaymukhametova
Federal Budget Institution of Science «Ufa Research Institute of Occupational Health and Human Ecology»
Russian Federation
Russian Federation
G. F. Muchammadiyeva
Federal Budget Institution of Science «Ufa Research Institute of Occupational Health and Human Ecology»
Russian Federation
Russian Federation
A. B. Bakirov
Federal Budget Institution of Science «Ufa Research Institute of Occupational Health and Human Ecology»
Russian Federation
Russian Federation
D. O. Karimov
Federal Budget Institution of Science «Ufa Research Institute of Occupational Health and Human Ecology»
Russian Federation
Russian Federation
References
1. Агзамова Г. С., Алиева А. М. Клинические особенности течения токсических гепатитов и их лечение (обзор литературы) // Медицина труда и промышленная экология. - 2009. - № 12. - С. 44-47.
2. Валеева Э. Т., Бакиров А. Б., Каримова Л. К., Галимова Р. Р. Особенности профессиональных заболеваний и интоксикаций у работников современных нефтехимических и химических производств // Бюллетень ВСНЦ СО РАМН. - 2009. - № 1 (65). - С. 59-63.
3. Tang K., Li Y., Zhang Z. et al. The PstI/RsaI and DraI polymorphisms of CYP2E1 and head and neck cancer risk: a meta-analysis based on 21 case-control studies // BMC Cancer. - 2010. - Vol. 10:575.
4. Лимборская С. А., Вербенко Д. А., Хрунин А. В. и соавт. Этническая геномика: анализ геномного полиморфизма популяций архангельской области // Вестник Московского университета. Серия 23: Антропология. - 2011. - № 3. - С. 100-119.
5. Российская энциклопедия по медицине труда / под ред. Н. Ф. Измерова. - М.: ОАО «Издательство «Медицина», 2005. - 656 с.
6. Podprasart V., Satayavivad J., Riengrojpitak S. et al. No direct hepatotoxic potential following a multiple-low dose paraquat exposure in rat as related to its bioaccumulation // Toxicol Lett. - 2007. - Vol. 170, № 3. - P. 193-202.
7. Sun F., Chen Y., Xiang Y., Zhan S. Drug-metabolising enzyme polymorphisms and predisposition to anti-tuberculosis drug-induced liver injury: a meta-analysis // Int J Tuberc Lung Dis. - 2008. - Vol. 12, № 9. - P. 994-1002.
8. Кравченко Н. О., Виноградова С. В. Значення генетичних факторів у розвитку і прогресуванні стеатозу печінки // Сучасна гастроентерол. - 2004. - № 4. - С. 107-114.
9. Coles B. F., Morel F., Rauch C. et al. Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression // Pharmacogenetics. - 2001. - Vol.11, № 8. - P.663-669.
10. Deng Q., He B., Pan Y. et al. Polymorphisms of GSTA1 contribute to elevated cancer risk: evidence from 15 studies // J BUON. - 2015. - Vol. 20, № 1. - P. 287-295.
11. Komiya Y., Tsukino H., Nakao H. et al. Human glutathione S-transferase A1, T1, M1, and P1 polymorphisms and susceptibility to prostate cancer in the Japanese population // J Cancer Res Clin Oncol. - 2005. - Vol. 131, № 4. - P. 238-242.
12. Ning B., Wang C., Morel F. et al. Human glutathione S-transferase A2 polymorphisms: variant expression, distribution in prostate cancer cases/controls and a novel form // Pharmacogenetics. - 2004. - Vol. 14, № 1. - P. 35-44.
Review
For citations:
Kutlina T.G., Galimova R.R., Shaymukhametova M.M., Muchammadiyeva G.F., Bakirov A.B., Karimov D.O. GENETIC PREDISPOSITION TO DEVELOPMENT OF TOXIC HEPATITIS. Experimental and Clinical Gastroenterology. 2016;(7):48-51. (In Russ.)
Views:
241
Email this article 