CHANGES IN LABORATORY MARKERS OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH LIVER CIRRHOSIS

Abstract

Aim of the research: To study the dynamics of endothelial dysfunction (ED) laboratory markers depending on the functional state of the liver in patients with severe forms of liver cirrhosis (LC). Materials and methods. 387 patients with LC were examined. In order to study the laboratory indexes of ED, levels of antitrombin (AT) III, D-dimer, von Willebrand Factor (wWF), endothelin-1 (Et-1) were determined. The extent of liver damage was determined using C13-methacetin breath test (C13-MBT) and taking into account the results of specially designed tests (Forns, FibroIndex, FIB-4, APRI, HALT-C, MDA, GUCI, FPI). Results. Our investigations confirm the presence of ED in patients with LC. The analysis of the results shows a dependincy between the severity of ED laboratory indexes and the level of LC severity: a progressive aggravation of ED indexes in proportion to liver damage severity growth. Conclusions: 1. Vessel ED is observed in patients with LC, which is manifested in the derangement of its biological markers concentration, namely Et-1, vWF, AT III and D-dimer. 2. In patients with LC a dependincy between the ED indexes and level of liver damage severity according to Child-Pugh was determined, namely the progression of biochemical ED markers of blood serum depending on the severity of liver damage according to C13-MBT results combined with the results of specialy designed tests (Forns, FibroIndex, Fib-4, APRI, HALT-C, MDA, GUCI, FPI).