HEPATOCELLULAR CARCINOMA. GENDER ASPECTS OF CARCINOGENESIS
Abstract
The article reviews contemporary data about influences of sex hormons (androgenes, estrogenes) and their nuclear receptors on development of hepatocellular carcinoma. Use of hepatoprotective drugs for treatment of chronic liver diseases and prophylactic of hepatocellular carcinoma should be correlated with potential hormonal effects of the treatment.
References
1. El-Serag H. B. Hepatocellular Carcinoma // N.E.J. M. - 2011. - V. 365. - P. 1118-1127.
2. Cancer Facts and Figures 2015 // Atlanta. American Cancer Society - 2015. - P. 38.
3. Blacher M. LeIeu H., Peck-Radosavljevic M. The burden of Liver disease in Europe: A review of available epidemiological data // Journal of Hepatology. - 2013. - V.58. - P. 593-608.
4. Каприн А. Д., Старинский В. В., Петрова Г. В. Злокачественные новообразования в России. - М.: ФГБУ МНИОИ им. П. А. Герцена, 2014.
5. Yang J. D., Roberts L. R. Hepatocellular Carcinoma: a global view // Nat. Rev. Gastroenterol. - Hepatol. - 2010. - V. 7. - P. 448-458.
6. Humphries C. P. Sex differences: Luck of the Chromosomes // Nature. - 2014. - V. 516, No 7529. - P. 10-15.
7. Шапошников А. В. Гепатоонкопревенция. Концепция и принципы реализации. Пособие для врачей // М: Фортепринт, 2013.
8. Lucas Z. D., Pangan C. P., Patal C. P., Ong J. The clinical profile of hepatocellular carcinoma patients at the Phillipine general hospital // Phill. J. Internal Medicine - 2009. - V. 47. - P. 1-9.
9. Morgan M. Y. Alcohol and Liver Cancer. World Digestive Health Day. - Brussels: UCL Institute for Liver and Digestive Health, 2013.
10. Huang Y-T., Jen C-L., Yang H-I. et al. Lifetime Risk and Sex Difference of Hepatocellular Carcinoma Among Patients with Chronic Hepatitis B and C // Journal of Clinical Oncology - 2011. - V. 22. - P. 1-9.
11. Baig S. Gender Disparaty in Infections of Hepatitis B Virus // J. of College of Physicians and Surgeons Pakistan. - 2009. - V. 10. - No 9. - P. 598-600.
12. Шапошников А. В., Рядинская Л. А., Перфилов А. А., Пащенко Д. Г. Гепатоцеллюлярный рак. Гендерные аспекты. // РГГК - 2015. - том ХХV. - N 1. - прил. N 45. - С. 47.
13. Durazzo M., Belci P., Collo A. et al. Gender specific medicine in Liver disease: A point of view // W.J.G. - 2014. - V. 20. - No 9. - P. 2127-2135.
14. Guy J., Peters M. Liver Disease in Woman: The Influence of Gender of Epidemiology, Natural History, and Patients outcames // Gastroenterology and Hepatology. - 2013. - V. 9. - No 10. - P. 633-639.
15. Brady C. W. Liver disease in menopause // W.J.G. - 2015. - V. 21. - No 25. - P. 7613-7620.
16. Dorak M. T., Karpuzoglu E. Gender differences in cancer Susceptibility: an inadequately addressed issue // Frontiers in Genetics. - 2012. - V. 3. - P. 1-11.
17. Le Bihan A. Sex Hormones // www.fastbleep.com, 25.05.2015.
18. Shen M., Shi H. Sex Hormones and Their Receptors Regulate Liver Energy Homeostasis // International Journal of Endocrinology. - 2015. - Artical ID 294278 - P. 1-12.
19. Federman D. D. The Biology of Human Sex Differences // N. E. J. Med - 2006. - V.354. - P. 1507-1514.
20. Wang A. G. The Expression of Estrogen Receptors in Hepatocellular Carcinoma in Korean Patients // Yonse, Med. J. - 2006 - V. 47. - N 6. - P. 811-816.
21. www.shiramillermed.com, 2014, 15.01.15.
22. Ye Tian, Xu Xil, Yao Lin et al. Androgen receptor in hepatocancerogenesis: Recent development and perspectives (Review) // Oncology Letters. - 2015. - V. 9. - P. 1983-1988.
23. Rando G., Wahli W. Sex differences in nuclear receptor-regulated liver metabolic pathways // Biochimica et Biophysica Acta. - 2011. - V. 180. - P. 964-973.
24. Kanda T., Yokosuka O. The androgen receptors as an emerging target in hepatocellular carcinoma // Journal of Hepatocellular Carcinoma. - 2015. - V. 2. - P. 91-99.
25. Shi L., Feng Y., Lin H. et al. Role of estrogen in hepatocellular carcinoma: is inflammation the key? // J. of Translation Medicine. - 2014. - V. 12. - P. 93-104.
26. Wands J. Hepatocellular Carcinoma and Sex // N. Engl. J. Med. - 2007. - V. 10. - P. 1974-1976.
27. Mc Glynn K. A., Sahasrabuddhe V. V., Campbell P. T. et al. Reproductive factors, exogenous hormone use and risk of hepatocellular carcinoma amond US women // British Journal of Cancer. - 2015. - V. 112. - P. 1266-1272.
28. Матвеев А. В. Гепатопротекторы. - Симферополь: Л. Т. «Ариал», 2013.
29. Kotb M. A. Molecular Mechanisms of Ursodeoxycholic Acid Toxicity and Side Effects: Ursodeoxycholic Acid Freezes Regeneration and induced Hibernation Mode // Int. J. Mol. Sci. - 2012. - V. 13. - P. 8882-8914.
30. Shi Q. Y., Kang B. H., Ma K. D. et al. Effects of ursodeoxycholic acid on the liver plasma membrane fluidity // PubMed. - 2003. V. 38, No 11. - P. 680-682.
31. Шепельская Н. Р., Проданчук Н. Г. Изофлавоноиды сои как ксеноэстрогены для человека // Фундаментальные исследования. - 2011. - N 9. - С. 593-598.
32. Schooling C. M., Yeung S. L., Freeman G., Cowling B. J. The effect of statins on testosterone in men and women, a systemic review and meta-analysis of randomired controlled trials // BMC Medicine. - 2013. - V. 11. - P. 57.
33. de Keyser C. E., de Lima F. P., de Jong F. H. et al. Use of statins is associated with lower serum total and non-sex hormone-binding globulin-bound testosterone levels in male participants of the Rotterdam Study // European J. of Endocrinology. - 2015. - V. 173. - P. 155-165.
Review
For citations:
Shaposhnikov A.V. HEPATOCELLULAR CARCINOMA. GENDER ASPECTS OF CARCINOGENESIS. Experimental and Clinical Gastroenterology. 2016;(7):4-12. (In Russ.)
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