Preview

Experimental and Clinical Gastroenterology

Advanced search

Hyperplasia of enterochromaffin-like (ECL) cells as a precursor of neuroendocrine gastric tumors in autoimmune gastritis

https://doi.org/10.31146/1682-8658-ecg-205-9-147-152

Abstract

The purpose of this publication is to update knowledge about chronic autoimmune gastritis and about cases of hyperplasia of enterochromaffin-like (ECL) cells as precursors of the development of neuroendocrine gastric tumor type 1 due to clinical example’s demonstration. Discussion: the types and main characteristics of neuroendocrine tumors of the stomach were discussed, in particular tumors type 1 associated with autoimmune gastritis. The mechanisms of formation of neuroendocrine tumors in the stomach against the background of an autoimmune process were presented, two clinical examples presenting the algorithm of diagnosis of autoimmune gastritis and associated neuroendocrine tumors were presented. Both clinical examples demonstrated the presence of subepithelial formations of the stomach body according to FGDS, which have not been morphologically identified. Timely repeated FGDS with sampling of biopsies according to the OLGA standard made it possible to verify the formations, and the serological markers helped in clarifying the diagnosis and morphological nature of tumors. Conclusion: analysis of clinical data, anamnesis and esophagoduodenoscopy with morphological evaluation of the gastric mucosa biopsy may help to find out the cause and nature of chronic inflammation in the gastric mucosa. Atrophy of the glands in the stomach body, pseudopiloric metaplasia, hyperplasia of enterochromaffin (ECL) cells are sufficient morphological criteria for autoimmune gastritis. The study of the level of chromogranin A in blood serum can be considered as a marker of the development of type 1 neuroendocrine gastric tumor in patients with autoimmune gastritis and the presence of polyps in the stomach body.

About the Authors

T. S. Krolevets
Omsk State Medical University
Russian Federation


M. A. Livzan
Omsk State Medical University
Russian Federation


S. I. Mozgovoy
Omsk State Medical University
Russian Federation


References

1. Minushkin O. N., Zverkov I. V., Topchiy T. B., Volodin D. V. Chronic gastritis: conception, typing, peculiarities of the course and outcomes. Kremlin Medicine Journal. 2007, nn. 2, pp. 19-22. (in Russ.) EDN: MTBVRJ. @@Минушкин О. Н., Зверков И. В., Топчий Т. Б., Володин Д. В. Хронический гастрит: понятие, типирование, особенности течения и исходы. Кремлевская медицина. Клинический вестник. 2007;2:19-22. - EDN: MTBVRJ.

2. Malfertheiner P., Megraud F., O’Morain C.A., et al. European Helicobacter Study Group. Management of Helicobacter pylori infection - the Maastricht IV/ Florence Consensus Report. Gut. 2012 May;61(5):646-64. doi:10.1136/gutjnl-2012-302084

3. Sugano K., Tack J., Kuipers E. J., et al. Kyoto global consensus report on Helicobacter pylori gastritis. Gut. 2015;64:1353-67. doi:10.1136/gutjnl-2015-309252

4. Niederle M.B., Hackl M., Kaserer K., et al: Gastroenteropancreatic neuroendocrine tumours: the current incidence and staging based on the WHO and European Neuroendocrine Tumour Society classification: an analysis based on prospectively collected parameters. EndocrRelatCancer. 2010;17:909-918. doi:10.1677/ERC-10-0152

5. Gibril F., Schumann M., Pace A., Jensen R. T. Multiple endocrine neoplasia type 1 and Zollinger-Ellison syndrome: a prospective study of 107 cases and comparison with 1009 cases from the literature. Medicine (Baltimore). 2004 Jan;83(1):43-83. doi:10.1097/01.md.0000112297.72510.32

6. Hassan M.M., Phan A., Li D., et al. Risk factors associated with neuroendocrine tumors: A U.S.-based case-control study.Int J Cancer. 2008 Aug 15;123(4):867-73. doi:10.1002/ijc.23529

7. Fanelli M.F., Chinen L. T., Begnami M. D., et al. The influence of transforming growth factor-α, cyclooxygenase-2, matrix metalloproteinase (MMP)-7, MMP-9 and CXCR4 proteins involved in epithelial-mesenchymal transition on overall survival of patients with gastric cancer. Histopathology. 2012 Aug;61(2):153-61. doi:10.1111/j.1365-2559.2011.04139.x

8. Germain M., Slack R. S. MCL-1 regulates the balance between autophagy and apoptosis. Autophagy. 2011 May;7(5):549-51. doi:10.4161/auto.7.5.15098

9. Rugge M., Correa P., Di Mario F., et al. OLGA staging for gastritis: a tutorial. Dig Liver Dis. 2008;40(8):650-8. doi:10.1016/j.dld.2008.02.030

10. Mozgovoy S.I., Kostenko M. B., Krolevets T. S., Livzan M. A. Autoimmune gastritis in the focus of clinician and morphologist. Farmateka. 2019;26(2):121-29. (in Russ.) doi:10.18565/pharmateca.2019.2.121-129 @@Мозговой С. И., Костенко М. Б., Кролевец Т. С., Ливзан М. А. Аутоиммунный гастрит в фокусе клинициста и морфолога. Фарматека. 2019;26(2):121-29. doi:10.18565/pharmateca.2019.2.121-129

11. Lazebnik L.B., Alexeenko S. A., Lyalukova E. A. et al. Recommendations on management of primary care patients with symptoms of dyspepsia. Experimental and Clinical Gastroenterology. 2018;(5):4-18. (In Russ.) @@Лазебник Л. Б., Алексеенко С. А., Лялюкова Е. А. и соавт. Рекомендации по ведению первичных пациентов с симптомами диспепсии. Экспериментальная и клиническая гастроэнтерология. 2018;(5):4-18.

12. Coati I., Fassan M., Farinati F., et al. Autoimmune gastritis: Pathologist’s viewpoint. World J Gastroenterol. 2015 Nov 14;21(42):12179-89. doi:10.3748/wjg.v21.i42.12179

13. Losik Ye.A., Selivanova L. S., Antonova T. V., Lapina T. L., Tertychny A. S., Ivashkin V. T. Morphological diagnostic criteria of autoimmune gastritis. Ross z gastroenterol gepatol koloproktol. 2016; 26(5):13-20. (in Russ.) @@Лосик Е. А., Селиванова Л. С., Антонова Т. В. и соавт. Морфологические критерии диагноза аутоиммунного гастрита. Рос журн гастроэнтерол гепатол колопроктол. 2016; 26(5):13-20.

14. Tozzoli R., Kodermaz G., Perosa A. R., et al. Autoantibodies to parietal cells as predictors of atrophic body gastritis: a five-year prospective study in patients with autoimmune thyroid diseases. Autoimmun Rev. 2010;10(2):80-3. doi:10.1016/j.autrev.2010.08.006

15. Livzan M. A., Kononov A. V., Mozgovoj S. I. [Post-radiation period of chronic gastritis associated with Helicobacter pylori infection]. Consilium Medicum, 2008, nn. 10(8), pp. 15-20. (in Russ.) EDN: RBSQKR. @@Ливзан М. А., Кононов А. В., Мозговой С. И. Постэрадикационный период хронического гастрита, ассоциированного с инфекцией Helicobacter pylori. Consilium Medicum. 2008;10(8):15-20. - EDN RBSQKR.

16. Alekberzade A.V., Krylov N. N., Lipnitskiĭ E. M., et al. Gastric neuroendocrine tumors. Pirogov Russian Journal of Surgery = Khirurgiya. Zurnal im. N. I. Pirogova. 2019;(12):111-120. (In Russ.) doi:10.17116/hirurgia2019121111 @@Алекберзаде А. В., Крылов Н. Н., Липницкий Е. М. и соавт. Нейроэндокринные опухоли желудка. Хирургия. Журнал им. Н. И. Пирогова. 2019;(12):111-120. doi:10.17116/hirurgia2019121111

17. Gianfranco DelleFave, Dik J. Kwekkeboom, Erik Van Cutsem, et al. Barcelona Consensus Conference participants. ENETS Consensus Guidelines for the Management of Patients with Gastroduodenal Neoplasms. Neuroendocrinology. 2012;95:74-87. doi:10.1159/000335595

18. Delle Fave G., O’Toole D., Sundin A., Taal B., et al. ENETS Consensus Guidelines Update for Gastroduodenal Neuroendocrine Neoplasms. Neuroendocrinology. 2016;103(2):119-24. doi:10.1159/000443168


Review

For citations:


Krolevets T.S., Livzan M.A., Mozgovoy S.I. Hyperplasia of enterochromaffin-like (ECL) cells as a precursor of neuroendocrine gastric tumors in autoimmune gastritis. Experimental and Clinical Gastroenterology. 2022;(9):147-152. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-205-9-147-152

Views: 1397


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1682-8658 (Print)