Experimental medicinal hepatitis. Hepatoprotective effects of the drug Laennec in models of toxic liver injury with paracetamol or alcohol
O. A. Gromova,
I. Yu. Torshin,
V. I. Demidov,
N. Yu. Zhidomorov,
A. G. Kalacheva,
T. E. Bogacheva,
T. R. Grishina https://doi.org/10.31146/1682-8658-ecg-199-3-86-92
Abstract
Hepatoprotectors are necessary for the treatment of alcoholic and non-alcoholic (including medicinal) liver damage. This paper presents the results of a study of the Laennec hepatoprotector, produced on the basis of pharmaceutically standardized human placental hydrolysates (HPH). The use of HSP in toxic liver damage with alcohol or paracetamol led to a significant decrease in markers of liver dysfunction (AST, ALT, bilirubin, MDA), which increase when the models are reproduced. The hepatoprotective effect of Laennec was confi rmed by the results of histological studies, indicating a reduction in infl ammation and preservation of the liver parenchyma. Histological studies also indicated the nephroprotective and cardioprotective effects of Laennec in liver damage with both alcohol and paracetamol.
About the Authors
O. A. Gromova
Federal Research Center Computer Science and Control, Russian Academy of Sciences
Russian Federation
Russian Federation
Olga A. Gromova - Professor, Doctor of Medical Sciences, Science Нead of the Institute of Pharmacoinformatics, leading researcher of the Department of Intellectual Systems; SPIN: 6317-9833, Scopus Author ID: 7003589812, ResearcherID: J-4946–2017.
42, Vavilova Str., Moscow, 119333
I. Yu. Torshin
Federal Research Center Computer Science and Control, Russian Academy of Sciences
Russian Federation
Russian Federation
Ivan Yu. Torshin. - PhD in Applied Mathematics, Institute of Pharmacoinformatics, leading researcher of the Department of Intellectual Systems; SPIN: 1375–1114, ResearcherID: C-7683–2018.
42, Vavilova Str., Moscow, 119333
V. I. Demidov
Ivanovo State Medical Academy
Russian Federation
Russian Federation
Demidov Vadim Igorevich - Head of the Department of Pathological Anatomy; ORCID: 0000-0002-1064-8201, Scopus Autor ID: 56806409700, ResearcherID: F-9158–2019.
8, Sheremetevskiy avenue, Ivanovo
N. Yu. Zhidomorov
Ivanovo State Medical Academy
Russian Federation
Russian Federation
Nikolai Yu. Zhidomorov - Associate Professor of the Department of Pharmacology; SPIN: 4226–9075.
8, Sheremetevskiy avenue, Ivanovo
A. G. Kalacheva
Ivanovo State Medical Academy
Russian Federation
Russian Federation
Alla G. Kalacheva - PhD, Associate Professor of the Department of Pharmacology and Clinical Pharmacology.
8, Sheremetevskiy avenue, Ivanovo
T. E. Bogacheva
Ivanovo State Medical Academy
Russian Federation
Russian Federation
Tatiana E. Bogacheva - PhD, Associate Professor of the Department of Pharmacology and Clinical Pharmacology.
8, Sheremetevskiy avenue, Ivanovo
T. R. Grishina
Ivanovo State Medical Academy
Russian Federation
Russian Federation
Tatiana R. Grishina - Нead of the Department of pharmacology.
8, Sheremetevskiy avenue, Ivanovo
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Review
For citations:
Gromova O.A., Torshin I.Yu., Demidov V.I., Zhidomorov N.Yu., Kalacheva A.G., Bogacheva T.E., Grishina T.R. Experimental medicinal hepatitis. Hepatoprotective effects of the drug Laennec in models of toxic liver injury with paracetamol or alcohol. Experimental and Clinical Gastroenterology. 2022;(3):86-92. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-199-3-86-92
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