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Экспериментальная и клиническая гастроэнтерология

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Биологическая роль казоморфинов (часть 2): роль в патологии человека

https://doi.org/10.31146/1682-8658-ecg-196-12-110-118

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Аннотация

Вторая часть обзора о казоморфинах посвящена роли этих биологически активных пептидов—продуктов гидролиза фосфопротеинов. Приведены убедительные данные о влиянии на систему иммунитета, антионкогенном действии, на моторику и тонус гладких мышечных волокон, способности управлять и другими аспектами деятельности ЖКТ — транспортной функцией кишечного эпителия, всасыванием воды и пр. Доказано действие β–казоморфинов на эндокринную систему, прежде всего на выделение инсулина и соматостатина. Особого внимания заслуживает вопрос влияния β–казоморфинов на материнский организм во время беременности и вскармливания новорожденного. Это важно, поскольку β–казоморфины могут проникать в ЦНС, являясь одним из факторов послеродового психоза и депрессии. Изучение механизмов действия β–казоморфинов приблизит учёных к пониманию генеза и патогенеза значительного спектра патологий.

Об авторах

А. И. Хавкин
Российский национальный исследовательский медицинский университет им. Н. И. Пирогова; Белгородский государственный исследовательский университет Министерства науки и высшего образования Российской Федерации
Россия

Хавкин Анатолий Ильич, д. м. н., профессор, главный научный сотрудник отдела гастроэнтерологии Научно-исследовательского клинического института педиатрии им. академика Ю. Е. Вельтищева

125412, Москва, ул. Талдомская, 2
308015, Белгородская область, Белгород, ул. Победы, д. 85



М. Н. Васиа
Больница “Doctors on duty clinic Labadi”
Россия

Васиа Мари Нечеса, главный врач больницы

GA000, Аккра, а/я OS 3410 ОСУ



В. П. Новикова
Санкт-Петербургский государственный педиатрический медицинский университет
Россия

Новикова Валерия Павловна, д. м. н., профессор, зав. кафедрой пропедевтики детских болезней с курсом общего ухода за детьми, зав. лабораторией «Медико-социальных проблем в педиатрии»

194100, Санкт-Петербург, ул. Литовская, д. 2, литера Ж



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Рецензия

Для цитирования:


Хавкин А.И., Васиа М.Н., Новикова В.П. Биологическая роль казоморфинов (часть 2): роль в патологии человека. Экспериментальная и клиническая гастроэнтерология. 2021;(12):110-118. https://doi.org/10.31146/1682-8658-ecg-196-12-110-118

For citation:


Khavkin A.I., Vasia M.N., Novikova V.P. The biological role of casomorphins (part 2): role in human pathology. Experimental and Clinical Gastroenterology. 2021;(12):110-118. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-196-12-110-118

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