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Experimental and Clinical Gastroenterology

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Cardiovascular comorbidity in non-alcoholic fatty liver disease

https://doi.org/10.31146/1682-8658-ecg-182-10-88-95

Abstract

The actual problem of modern medicine is the search for links between non-alcoholic fatty liver disease and cardiovascular diseases. The real clinical practice needs to deepen knowledge about the mutual infl uence of  these two diseases and develop algorithms to accompany these patients.
A review of current literature shows data on increasing cardiovascular risks and accelerating progression of liver  pathology in the combination of non-alcoholic fatty liver disease and cardiovascular disease. The article describes the links of pathogenesis of non-alcoholic fatty liver disease aff ecting the development of cardiovascular diseases (insulin resistance, hypoadiponectinemia, hyperleptinemia, lipid metabolism disorders, activation of infl ammation, etc.). The role of infl ammation, hormonal changes and the infl uence of intestinal microbiota on the course of both diseases has been demonstrated. 
The review presents data on the infl uence of common risk factors (lipid metabolism disorder, carbohydrate metabolism disorder, obesity, etc.) on the course of both pathologies. The review presents the literature data on the connection of non-alcoholic fatty liver disease with the development of arterial hypertension (primarily due to an increase in vascular wall stiff ness), coronary heart disease (primarily due to endothelial dysfunction and hyperlipidemia), heart rhythm disorders, heart failure, cerebrovascular diseases. It has been shown that the connection between non-alcoholic fatty liver disease and cardiovascular diseases is bilateral and cardiovascular diseases can aggravate the course of liver diseases.
The importance of further study of this issue is due to the mutual infl uence of non-alcoholic fatty liver disease and  cardiovascular disease not only on the prognosis, but also on the tactics of patient management.

About the Authors

A. Yu. Timakova
Federal State Funded Educational Institution for Higher Education Omsk State Medical University Ministry of Public Health
Russian Federation
medical faculty, student

Russian Federation, Omsk, Lenin street, 12, Russia


Yu. P. Skirdenko
Federal State Funded Educational Institution for Higher Education Omsk State Medical University Ministry of Public Health
Russian Federation
assistant of the department of faculty therapy, occupational disease, PhD

Russian Federation, Omsk, Lenin street, 12, Russia


M. A. Livzan
Federal State Funded Educational Institution for Higher Education Omsk State Medical University Ministry of Public Health
Russian Federation

D. Sci. (Med.), Professor, Rector, Head of the Department of Faculty Therapy, Occupational Diseases

Scopus Author ID: 24341682600

Russian Federation, Omsk, Lenin street, 12, Russia



T. S. Krolevets
Federal State Funded Educational Institution for Higher Education Omsk State Medical University Ministry of Public Health
Russian Federation
assistant of the department of faculty therapy, occupational disease, PhD

Russian Federation, Omsk, Lenin street, 12, Russia


N. A. Nikolaev
Federal State Funded Educational Institution for Higher Education Omsk State Medical University Ministry of Public Health
Russian Federation
professor of the department of faculty therapy, occupational disease, associate professor, MD

Russian Federation, Omsk, Lenin street, 12, Russia


A. V. Nelidova
Federal State Funded Educational Institution for Higher Education Omsk State Medical University Ministry of Public Health
Russian Federation
associate professor of the department of propaedeutics of internal diseases, associate professor, PhD

Russian Federation, Omsk, Lenin street, 12, Russia


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Review

For citations:


Timakova A.Yu., Skirdenko Yu.P., Livzan M.A., Krolevets T.S., Nikolaev N.A., Nelidova A.V. Cardiovascular comorbidity in non-alcoholic fatty liver disease. Experimental and Clinical Gastroenterology. 2020;(10):88-95. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-182-10-88-95

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