Pathomorphological and etiological characteristics of infectious liver injury and gastrointestinal tract in newborns
https://doi.org/10.31146/1682-8658-ecg-182-10-65-70
Abstract
Aim study. To study the etiology, nosological structure and pathomorphological changes in the liver and gastrointestinal tract in deceased newborns with perinatal infectious diseases.
Materials and methods. In total, 48 protocols of pathological autopsy of the deceased newborns were studied in 2018 and 2019. Gender, age of newborns, maternal gestational age, post-mortem bacteriological studies, as well as macroand microscopic changes in the gastrointestinal tract and liver were evaluated.
Results. Hepatitis and enterocolitis were part of generalized intrauterine infection and early neonatal sepsis — 19 cases each (39.6%), mainly in preterm infants (93.8%). Positive results of bacteriological studies of autopsy material were noted in 12% of cases. The most common causative agent in post-mortem bacteriological examination in early and late neonatal sepsis was Klebsiella pneumoniae. The main morphological manifestations of hepatitis in newborns were lobular hepatitis of various degrees of activity — 63.8%, as well as fetal giant cell hepatitis — 21.4%. Morphological changes in gastroenterocolitis were characterized mainly by the development of erosive-ulcerative enterocolitis (37.8%), productive enterocolitis (46.9%), less often serous-catarrhal, ulcerative-necrotic enterocolitis (6.25%).
About the Authors
A. P. Nadeev
Federal State Budget Educational Institution of Higher Education “Novosibirsk State Medical University” Ministry of Health of the Russian Federation
Russian Federation
professor, director of the Department of Pathological Anatomy
630091, Novosibirsk, Krasnyj prospect, 52
Russian Federation
professor, director of the Department of Pathological Anatomy
630091, Novosibirsk, Krasnyj prospect, 52
M. A. Karpov
Federal State Budget Educational Institution of Higher Education “Novosibirsk State Medical University” Ministry of Health of the Russian Federation
Russian Federation
docent of the Department of Pathological Anatomy
630091, Novosibirsk, Krasnyj prospect, 52
Russian Federation
docent of the Department of Pathological Anatomy
630091, Novosibirsk, Krasnyj prospect, 52
A. A. Abyshev
Federal State Budget Educational Institution of Higher Education “Novosibirsk State Medical University” Ministry of Health of the Russian Federation
Russian Federation
aspirant of the Department of Pathological Anatomy
630091, Novosibirsk, Krasnyj prospect, 52
Russian Federation
aspirant of the Department of Pathological Anatomy
630091, Novosibirsk, Krasnyj prospect, 52
E. V. Ovcyanko
Federal State Budget Educational Institution of Higher Education “Novosibirsk State Medical University” Ministry of Health of the Russian Federation
Russian Federation
professor of the Department of Human Anatomy Acad. Yu. I. Borodin
630091, Novosibirsk, Krasnyj prospect, 52
Russian Federation
professor of the Department of Human Anatomy Acad. Yu. I. Borodin
630091, Novosibirsk, Krasnyj prospect, 52
References
1. Tsinserling V. A. Intrauterine infections: a modern view of the problem. Journal of Infectology. 2014. vol. 6, No. 4, pp.13–18.
2. Fleischmann-Struzek C., Goldfarb D. M., Schlattmann P., et al. The global burden of paediatric and neonatal sepsis: a systematic review. The Lancet Respiratory medicine. 2018, Vol. 6, no.3, pp. 223–230.
3. Tkachenko A. K., Romanova O. N., and Marochkina E. M. To the concept of «intrauterine infection and intrauterine infection». Journal of the Grodno State Medical University. 2017, No. 1, pp. 103–109.
4. Tsinserling V. A., Melnikova. Perinatal infections. SPb. Elby, 2002. 352 P.
5. Nadeev A. P., Shkurupiy V. A., Marinkin I. O. Liver and placenta in the peri- and postnatal periods in pathology: Clinical experimental study. Novosibirsk: Nauka, 2014. 244 p.
6. Camacho-Gonzalez A., Spearman P. W., Stoll B. J. Neonatal infectious diseases: evaluation of neonatal sepsis. Pediatric clinics of North America. 2013, Vol. 60, no.2, pp. 367–389.
7. Novopoltseva E. G., Vorobieva V. A., Ovsyannikova O. B. et al. Intrauterine infections in premature infants with ulcerative necrotizing colitis. Treatment and prevention. 2015;16(4):16–23.
8. Chubarova AI. Necrotizing enterocolitis in newborns. Eksp Klin Gastroenterol. 2012;(1):70–5. Russian. PMID: 22808783.
9. Nadeev AP, Koziany MA, AA Abyshev, et al. Communityacquired pneumonia: epidemiology, etiology and clinical and morphological parallels. Journal of Siberian Medical Sciences. 2019, No. 4, pp. 20–29.
10. Hicks J., Barrish J., Zhu S. H. Neonatal syncytial giant cell hepatitis with paramyxoviral-like inclusions. Ultrastruct Pathol. 2001, Vol. 25, No.1, pp. 65–71.
11. Torbenson M., Hart J., Westerhoff M., et al. Neonatal giant cell hepatitis: histological and etiological findings. Am J Surg Pathol. 2010, Vol. 34, no.10, pp. 1498–1503. doi: 10.1097/PAS.0b013e3181f069ab
12. Bihari C., Rastogi A., Sarin K. Postinfantile giant cell hepatitis: an etiological and prognostic perspective. Hepatitis research and treatment. 2017. http://dx.doi.org/10.1155/2013/601290.
13. Sergienko E. N., Romanova O. N., Klyuchareva A. A. et al. Clinical observations of giant cell hepatitis in children. Journal of Infectology. 2019.;11(4):153–160.
14. Komarova D. V., Tsinserling V. A. Morphological diagnosis of liver infectious lesions. SPB. SOTIS, 1999, 243p.
15. Ushakova R. A., Kovtun O. P., Krokhina N. B. Clinical and morphological features of lesions of the hepatobiliary system in children of the first year of lifeю Ural medical journal. 2010. vol. 71, No. 6, pp. 44–49.
16. Beniova S. N., Stolina M. L., Rudenko N. V. et al. Diseases of the gastrointestinal tract in full-term and premature newborns. Modern problems of science and education. 2012. No. 3, pp. 16–24.
Review
For citations:
Nadeev A.P., Karpov M.A., Abyshev A.A., Ovcyanko E.V. Pathomorphological and etiological characteristics of infectious liver injury and gastrointestinal tract in newborns. Experimental and Clinical Gastroenterology. 2020;(10):65-70. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-182-10-65-70
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