Clinico-epidemiological features and molecular-genetic characteristics of acute intestinal infections of viral etiology in Novosibirsk
https://doi.org/10.31146/1682-8658-ecg-182-10-11-17
Abstract
The objective of the study: to establish the frequency of acute intestinal infections of viral etiology in the Novosibirsk region, their clinical and epidemiological features and molecular and genetic diversity to justify rational approaches to diagnosis and treatment.
Materials and methods: 1500 patients aged 18 to 91 years were hospitalized with a diagnosis of acute intestinal infection (AII) from January 2016 to February 2018. Along with conventional diagnostic methods, faeces were examined by PCR for the presence of astroviruses, as well as rotaviruses and noroviruses of the second genogroup.
Results: the Viral etiology of AII was established in 332 (22.1%) patients. Astrovirus infection (AII) was diagnosed in 27 patients (1.7%), second in frequency to noroviruses (NVI) (13.3%) and rotaviruses (RVI) (7%). Viral diarrhea were detected more often in women 56.9 per cent. The age of patients varied from 18 to 91 years and averaged (30.2 ± 1.9) years. In half of the cases of AVI (48.1%), the use of seafood on the eve of the disease was established. The moderate form was registered in 90.1% of patients with viral OCI, and in 9.9% — severe. Severe forms of NVI occurred in 13.6%, more often than in rvi-5 patients (4.7%); and AVI (3.7%). It was found that in the majority of patients (96.3%) with severe dehydration, recombinant strains of noroviruses (GII.P17/GII. 17, GII.Pe/GII.4 Sydney). In 93.1% of patients with viral OCI, the disease started with fever. The vast majority of patients with the viral etiology of OKI had multiple watery diarrhea (91.6%). In the hemogram of the majority of patients with viral OCI, the number of white blood cells was normal at admission. The average values of white blood cells in patients with AII of diff erent etiology did not differ.
Conclusion: The absence of specifi c manifestations of viral AII of various etiologies determines the need to introduce test systems for verifi cation of viral pathogens into clinical practice. It is advisable to determine the genotypes of noroviruses both from an epidemiological point of view and to predict the risk of severe forms in cases of detection of new, previously unknown, recombinant strains.
About the Authors
D. V. Kapustin
Federal State Budget Educational Institution of Higher Education “Novosibirsk State Medical University” Ministry of Health of the Russian Federation;
“City Infectious Clinical Hospital No.1”
Russian Federation
assistant of the department of Infectious Diseases
Russian Federation
assistant of the department of Infectious Diseases
630091, Novosibirsk, Krasnyj prospect, 52
Novosibirsk, Sem'i-SHamshinyh, 40, Russia
E. I. Krasnova
Federal State Budget Educational Institution of Higher Education “Novosibirsk State Medical University” Ministry of Health of the Russian Federation;
“City Infectious Clinical Hospital No.1”
Russian Federation
Head of the department of Infectious Diseases, Doctor of Medicine, professor
Russian Federation
Head of the department of Infectious Diseases, Doctor of Medicine, professor
630091, Novosibirsk, Krasnyj prospect, 52
Novosibirsk, Sem'i-SHamshinyh, 40, Russia
E. V. Zhirakovskaia
Institute of Chemical Biology and Fundamental Medicine of the SB RAS
Russian Federation
Russian Federation
Laboratory of Molecular Microbiology, research fellow, Ph.D.
Novosibirsk, pr. Ak. Lavrent'eva, 8, Russia
N. I. Khokhlova
Federal State Budget Educational Institution of Higher Education “Novosibirsk State Medical University” Ministry of Health of the Russian Federation;
“City Infectious Clinical Hospital No.1”
Russian Federation
assistant professor of the department of Infectious Diseases, candidate of medical sciences
Russian Federation
assistant professor of the department of Infectious Diseases, candidate of medical sciences
630091, Novosibirsk, Krasnyj prospect, 52
Novosibirsk, Sem'i-SHamshinyh, 40, Russia
S. N. Sokolov
Institute of Chemical Biology and Fundamental Medicine of the SB RAS;
State Research Center of Virology and Biotechnology Vector
Russian Federation
Russian Federation
research fellow
Novosibirsk, pr. Ak. Lavrent'eva, 8, Russia
Koltsovo, Novosibirsk, Russia
N. V. Tikunova
Institute of Chemical Biology and Fundamental Medicine of the SB RAS
Russian Federation
Russian Federation
Head of the Laboratory of Molecular Microbiology, Doctor of Biological Sciences
Novosibirsk, pr. Ak. Lavrent'eva, 8, Russia
I. V. Kuimova
Federal State Budget Educational Institution of Higher Education “Novosibirsk State Medical University” Ministry of Health of the Russian Federation;
“City Infectious Clinical Hospital No.1”
Russian Federation
assistant professor of the department of Infectious Diseases, Doctor of Medicine
Russian Federation
assistant professor of the department of Infectious Diseases, Doctor of Medicine
630091, Novosibirsk, Krasnyj prospect, 52
Novosibirsk, Sem'i-SHamshinyh, 40, Russia
A. N. Evstropov
Federal State Budget Educational Institution of Higher Education “Novosibirsk State Medical University” Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Head of the department of Microbiology, Doctor of Medicine, professor
630091, Novosibirsk, Krasnyj prospect, 52
V. G. Kuznetsova
Federal State Budget Educational Institution of Higher Education “Novosibirsk State Medical University” Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
assistant professor of the department of Infectious Diseases, Doctor of Medicine
630091, Novosibirsk, Krasnyj prospect, 52
L. M. Panasenko
Federal State Budget Educational Institution of Higher Education “Novosibirsk State Medical University” Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
assistant professor of the department of Propaedeutics Childhood Diseases, Doctor of Medicine
630091, Novosibirsk, Krasnyj prospect, 52
I. Ya. Izvekova
Federal State Budget Educational Institution of Higher Education “Novosibirsk State Medical University” Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
assistant professor of the department of Infectious Diseases, Doctor of Medicine
630091, Novosibirsk, Krasnyj prospect, 52
L. V. Lukashova
Siberian State Medical University of the Ministry of Health of Russia
Russian Federation
Russian Federation
Head of the Department of Infectious Diseases and Epidemiology, Doctor of Medicine, Associate Professor
Tomsk, Moskovskij trakt, 2, Russia
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For citations:
Kapustin D.V., Krasnova E.I., Zhirakovskaia E.V., Khokhlova N.I., Sokolov S.N., Tikunova N.V., Kuimova I.V., Evstropov A.N., Kuznetsova V.G., Panasenko L.M., Izvekova I.Ya., Lukashova L.V. Clinico-epidemiological features and molecular-genetic characteristics of acute intestinal infections of viral etiology in Novosibirsk. Experimental and Clinical Gastroenterology. 2020;(10):11-17. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-182-10-11-17
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