Virus-bacterial association of SARS-CoV-2 with mycoplasma as one of the possible causes of severe forms of COVID-19
https://doi.org/10.31146/1682-8658-ecg-179-7-143-151
Abstract
The article formulates a hypothesis about the virus-bacterial association SARS-CoV-2 and the representative of the class Mollicutes as the main reason for the development of severe forms of COVID-19.
About the Authors
L. N. Chikhireva
Multidisciplinary medical center of the Bank of Russia
Russian Federation
Russian Federation
Ludmila N. Chikhireva - Candidate of Medical Sciences, cardiologist.
Moscow 117593, prosp. Sevastopolskiy, 66.
A. M. Cherkashov
Multidisciplinary medical center of the Bank of Russia
Russian Federation
Russian Federation
Andrey M. Cherkashov - Corresponding Member of Russian Academy of Natural Sciences, Doctor of Medical Sciences, Chief Executive Officer.
Moscow 117593, prosp. Sevastopolskiy, 66.
E. D. Li
Multidisciplinary medical center of the Bank of Russia
Russian Federation
Russian Federation
Elena D. Li - Doctor of Medical Sciences, Professor, medical consultant.
Moscow 117593, prosp. Sevastopolskiy, 66.
O. A. Chikhirev
Multidisciplinary medical center of the Bank of Russia
Russian Federation
Russian Federation
Oleg A. Chikhirev - Candidate of Medical Sciences, Head of the Cardiology Department.
Moscow 117593, prosp. Sevastopolskiy, 66.
Yu. N. Belenkov
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Russian Federation
Yury N. Belenkov - Academician of Russian Science Academy, MD, PhD, Head of Hospital Therapy Department.
Moscow.
References
1. Undiagnosed pneumonia - China (HU): RFI. Archive Number: 20191230.6864153 https://promedmail.org/promed-post/?id=6864153. (Available 2019-12-30 23:59:00)
2. Undiagnosed pneumonia - China (HU) (07): official confirmation of novel coronavirus. Archive Number: 20200108.6878869, https://promedmail.org/promed-post/?id=20200108.6878869. (Available 2020-01-08 23:19:25)
3. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [published correction appears in Lancet. 2020 Jan 30;:]. Lancet. 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5
4. Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579(7798):270-273. doi:10.1038/s41586-020-2012-7
5. Hoff mann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020;181(2):271-280.e8. doi:10.1016/j.cell.2020.02.052
6. Guan WJ, Ni ZY, Hu Y, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;382(18):1708-1720. doi:10.1056/NEJMoa2002032
7. Yang Х., Yu Y., Xu J. et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med 2020; 8: 475-81
8. Epidemiology Working Group for NCIP Epidemic Response, Chinese Center for Disease Control and Prevention. Zhonghua Liu Xing Bing Xue Za Zhi. 2020;41(2):145-151. doi:10.3760/cma.j.issn.0254-6450.2020.02.003
9. Mao L, Jin H, Wang M, et al. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China [published online ahead of print, 2020 Apr 10]. JAMA Neurol. 2020; e201127. doi:10.1001/jama-neurol.2020.1127
10. Poyiadji N, Shahin G, Noujaim D, Stone M, Patel S, Griffi th B. COVID-19-associated acute hemorrhagic necrotizing encephalopathy: CT and MRI features. Radiology 2020; Mar 31. https://doi.org/10.1148/radi-ol.2020201187
11. Moriguchi T, Harii N, Goto J, et al. A first case of menin-gitis/encephalitis associated with SARS-Coronavirus-2 [published online ahead of print, 2020 Apr 3]. Int J Infect Dis. 2020;94:55-58. doi:10.1016/j.ijid.2020.03.062
12. Virani A., Rabold E., Hanson T. et al. Guillain-Barre Syndrome associated with SARS-CoV-2 infection IDCases Vol 20, 2020, e00771. http://creativecommons.org/licenses/by-nc-nd/4.0/
13. Giacomelli A, Pezzati L, Conti F, et al. Self-reported olfactory and taste disorders in SARS-CoV-2 patients: a cross-sectional study [published online ahead of print, 2020 Mar 26]. Clin Infect Dis. 2020; ciaa330. doi:10.1093/cid/ciaa330
14. Lechien JR, Chiesa-Estomba CM, De Siati DR, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. European Archives of Oto-rhino-laryngology: Official Journal of the European Federation of Oto-rhino-laryngological Societies (EUFOS): Affiliated with the German Society for Oto-rhino-laryngology - Head and Neck Surgery. 2020 Apr. DOI: 10.1007/s00405-020-05965-1
15. Nobel YR, Phipps M, Zucker J, Lebwohl B, Wang TC, Sobieszczyk ME, Freedberg DE, Gastrointestinal Symptoms and COVID-19: Case-Control Study from the United States, Gastroenterology (2020), doi: https://doi.org/10.1053/j.gastro.2020.04.017.
16. Sultan S, Altayar O, Siddique SM, Davitkov P, Feuerstein JD, Lim JK, Falck-Ytter Y, El-Serag HB, On behalf of the AGA, AGA Institute Rapid Review of the GI and Liver Manifestations of COVID-19, Meta-Analysis of International Data, and Recommendations for the Consultative Management of Patients with COVID-19, Gastroenterology (2020), doi: https://doi.org/10.1053/j.gastro.2020.05.001.
17. Hadi A, Werge M, Kristiansen KT, et al. Coronavirus Disease-19 (COVID-19) associated with severe acute pancreatitis: Case report on three family members. Pancreatology. 2020;20(4):665-667. doi:10.1016/j.pan.2020.04.021
18. Recalcati S. Cutaneous manifestations in COVID-19: a first perspective J Eur Acad Dermatol Venereol. 2020 Mar 26. https://doi.org/10.1111/JDV.16387
19. Casas C. G., Catala A., Hernandez G. C. et al. Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases. Br J Dermatol. 2020 Apr 29. doi: 10.1111/bjd.19163.
20. Klinicheskaya kcharakteristika kognych proayvlenij pri novoy koronavirusnoy infekcii COVID-19, vysvannoy SARS-CoV-2. [Clinical characteristics of skin manifestations with a new coronavirus infection COVID-19 caused by SARS-CoV-2] (online first, Russian Journal of Clinical Dermatology and Venereology = Klinicheskaya der-matologiya i venerologiya. 2020; 21(3). ISSN1997-2849 (Print), ISSN2309-4877 (Online) https://mosderm.ru/uploads/news/5eb5306b244d/5eb53960046e.pdf
21. Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study [published correction appears in Lancet Respir Med. 2020 Apr;8(4): e26]. Lancet Respir Med. 2020;8(5):475-481. doi:10.1016/S2213-2600(20)30079-5
22. Wang D, Yin Y, Hu C, et al. Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China. Crit Care. 2020;24(1):188. Published 2020 Apr 30. doi:10.1186/s13054-020-02895-6
23. Bangalore S, Sharma A, Slotwiner A, et al. ST-Segment Elevation in Patients with Covid-19 - A Case Series [published online ahead of print, 2020 Apr 17]. N Engl J Med. 2020; NEJMc2009020. doi:10.1056/NEJMc2009020
24. Zeng, J., Liu, Y., Yuan, J. et al. First case of COVID-19 complicated with fulminant myocarditis: a case report and insights. Infection (2020). https://doi.org/10.1007/s15010-020-01424-5
25. Cizgici AY, Zencirkiran Agus H, Yildiz M. COVID-19 myopericarditis: It should be kept in mind in today's conditions [published online ahead of print, 2020 Apr 28]. Am J Emerg Med. 2020; S0735-6757(20)30310-7. doi:10.1016/j.ajem.2020.04.080
26. Inciardi RM, Lupi L, Zaccone G, et al. Cardiac Involvement in a Patient With Coronavirus Disease 2019 (COVID-19). JAMA Cardiol. Published online March 27, 2020. doi:10.1001/jamacardio.2020.1096
27. Tung-Chen Y. Acute pericarditis due to COVID-19 infection: An underdiagnosed disease? [published online ahead of print, 2020 May 4]. Med Clin (Barc). 2020; S0025-7753(20)30257-8. doi:10.1016/j.medc-li.2020.04.007
28. Toubiana J, Poirault C, Corsia A, et al. Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study. BMJ. 2020;369: m2094. Published 2020 Jun 3. doi:10.1136/bmj.m2094
29. Ramcharan T, Nolan O, Lai CY, et al. Paediatric Inflammatory Multisystem Syndrome: Temporally Associated with SARS-CoV-2 (PIMS-TS): Cardiac Features, Management and Short-Term Outcomes at a UK Tertiary Paediatric Hospital [published online ahead of print, 2020 Jun 12]. Pediatr Cardiol. 2020;1-11. doi:10.1007/s00246-020-02391-2
30. Zhou F., Yu T., Du R. et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet, Vol 395, 2020, p. 1054-1062, https://doi.org/10.1016/S0140-6736(20)30566-3.
31. Cui S, Chen S, Li X, Liu S, Wang F. Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. J Thromb Haemost. 2020. doi: https://doi.org/10.1111/jth.14830.
32. Klok FA, Kruip MJHA, van der Meer NJM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19 [published online ahead of print, 2020 Apr 10]. Thromb Res. 2020; S0049-3848(20)30120-1. doi:10.1016/j.thromres.2020.04.013
33. Dolhnikoff M., Duarte-Neto A.N., de Almeida Monteiro R. A. Pathological evidence of pulmonary thrombotic phenomena in severe COVID-19. doi: 10.1111/JTH.14844
34. Li H., Liu L., Zhang D. et al. SARS-CoV-2 and viral sepsis: observations and hypotheses. www.thelancet.com Published online April 17, 2020 https://doi.org/10.1016/S0140-6736(20)30920-X
35. Barnes BJ, Adrover JM, Baxter-Stoltzfus A, et al. Targeting potential drivers of COVID-19: Neutrophil extracellular traps. J Exp Med. 2020;217(6): e20200652. doi:10.1084/jem.20200652
36. Saghazadeh A., Rezaei N., Towards treatment planning of COVID-19: Rationale and hypothesis for the use of multiple immunosuppressive agents: anti-antibodies, immunoglobulins, and corticosteroids, International Immunopharmacology (2020), doi: https://doi.org/10.1016/j.intimp.2020.106560
37. Glybochko P, Fomin V, Avdeev S et al. Clinical characteristics of 1007 intensive care unit patients with SARS-CoV-2 pneumonia. Clin pharmacol ther 2020;29(2):21-29. https://clinpharm-journal.ru/articles/opublikovannye-onlajn/klinicheskaya-harakteristi-ka-1007-bolnyh-tyazheloj-sars-cov-2-pnevmoniej-nuzhdavshihsya-v-respiratornoj-podderzhke/?en=1
38. Bhatraju PK, Ghassemieh BJ, Nichols M, et al. Covid-19 in Critically Ill Patients in the Seattle Region - Case Series [published online ahead of print, 2020 Mar 30]. N Engl J Med. 2020; NEJMoa2004500. doi:10.1056/NEJMoa2004500
39. Barton L.M., MD, Duval E. J., Stroberg E. et al. COVID-19 Autopsies Oklahoma USA. American Journal of Clinical Pathology, Vol 153, Issue 6, p. 725-733, https://doi.org/10.1093/ajcp/aqaa062
40. Magro C, Mulvey JJ, Berlin D, et al. Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases. Transl Res. 2020;220:1-13. doi:10.1016/j.trsl.2020.04.007
41. Buja LM, Wolf DA, Zhao B, et al. The emerging spectrum of cardiopulmonary pathology of the coronavirus disease 2019 (COVID-19): Report of 3 autopsies from Houston, Texas, and review of autopsy findings from other United States cities [published online ahead of print, 2020 May 7]. Cardiovasc Pathol. 2020;48:107233. doi:10.1016/j.carpath.2020.107233
42. Varga Z., Flammer A. J., Steiger P. et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet, Vol 395, 2020, https://doi.org/10.1016/S0140-6736(20)30937-5
43. Bhayana R., Som A., Li M. D. et al. Abdominal Imaging Findings in COVID-19: Preliminary Observations. Radiology May 11 2020, https://doi.org/10.1148/radiol.2020201908
44. Zou L, Ruan F, Huang M, et al. SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients. N Engl J Med. 2020;382(12):1177-1179. doi:10.1056/NEJMc2001737
45. Wolfel R., Corman V. M., Guggemos W. et al. Virological assessment of hospitalized patients with COVID-2019. Nature (2020). https://doi.org/10.1038/s41586-020-2196-x
46. Kolobuhina L. V. Klinika i lechenie grippa.[Clinic and treatment of influenza]. Regulayrnye vypuski « RMG», 2001, p.710 https://www.rmj.ru/archive/respiratornye_infektsii_urologiya_infektsii_i_invazii/
47. Henry B.M., Santos de Oliveira M. H., Benoit S. et al. Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-anal-ysis. Clin Chem Lab Med 2020; https://doi.org/10.1515/cclm-2020-0369
48. Ruan Q., Yang K., Wang W. et al. Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China. Intensive Care Med 46, 846-848 (2020). https://doi.org/10.1007/s00134-020-05991-x
49. Velavan T. P., Meyer С. G. Mild versus severe COVID-19: Laboratory markers. International Journal of Infectious Diseases, Vol 95, 2020, p. 304-307, https://doi.org/10.1016/j.ijid.2020.04.061.
50. Fan J, Wang H, Ye G, et al. Letter to the Editor: Low-density lipoprotein is a potential predictor of poor prognosis in patients with coronavirus disease 2019. Metabolism. 2020;107:154243. doi:10.1016/j.metabol.2020.154243
51. Borchsenius SN, Chernova OA, Chernov VM, Vonskij MS. Mikoplazmy: molekularnaya i kletochnaya biologiya, vzaimodeystviye s immunnoy sistemoy mlekopitay-ushchikh, patogennost', diagnostica. [Mycoplasmas: molecular and cellular biology, interaction with the mammalian immune system, pathogenicity, diagnosis.] Science Publ., 2002, p. 28 https://www.rfbr.ru/rffi/ru/journal/o_66104.
52. Borchsenius SN, Chernova OA, Chernov VM, Vonskij MS. Mikoplazmy: molekularnaya i kletochnaya biologiya, vzaimodeystviye s immunnoy sistemoy mlekopitay-ushchikh, patogennost', diagnostica. [Mycoplasmas: molecular and cellular biology, interaction with the mammalian immune system, pathogenicity, diagnosis.] Science Publ., 2002, p. 40 https://www.rfbr.ru/rffi/ru/journal/o_66104
53. Borchsenius SN, Chernova OA, Chernov VM, Vishnyakov IE. Mikoplazmy v biologii i medicine na-chala XXI veka. [Mycoplasmas in biology and medicine at the beginning of the 21st century.] Science Publ., 2016, pp.175-176. https://www.rfbr.ru/rffi/ru/journal/o_1965595#1
54. Lu C-w, Liu X-f, Jia Z-f. 2019-nCoV transmission through the ocular surface must not be ignored. Lancet 2020, 395: e39. https://doi.org/10.1016/S0140-6736(20)30313-5
55. Waites KB, Xiao L, Liu Y, Balish MF, Atkinson TP. Mycoplasma pneumoniae from the Respiratory Tract and Beyond. Clin Microbiol Rev. 2017;30(3):747-809. doi:10.1128/CMR.00114-16
56. Borchsenius SN, Chernova OA, Chernov VM, Vishnyakov IE. Mikoplazmy v biologii i medicine na-chala XXI veka. [Mycoplasmas in biology and medicine at the beginning of the 21st century.] Science Publ., 2016, pp.159-164
57. Quinti I, Lougaris V, Milito C, et al. A possible role for B cells in COVID-19? Lesson from patients with agammaglobulinemia [published online ahead of print, 2020 Apr 22]. J Allergy Clin Immunol. 2020; S0091-6749(20)30557-1. doi:10.1016/j.jaci.2020.04.013
58. Narita M. 2016. Classification of extrapulmonary manifestations due to Mycoplasma pneumoniae infection on the basis of possible pathogenesis. Front Microbiol 7:23. doi:10.3389/fmicb.2016.00023.
59. Gautret P, Lagier JC, Parola P, et al. Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study. Travel Med Infect Dis. 2020;34:101663. doi:10.1016/j.tmaid.2020.101663
60. Damle B, Vourvahis M, Wang E, Leaney J, Corrigan B. Clinical Pharmacology Perspectives on the Antiviral Activity of Azithromycin and Use in COVID-19 [published online ahead of print, 2020 Apr 17]. Clin Pharmacol Ther. 2020;10.1002/cpt.1857. doi:10.1002/cpt.1857
61. Mayanskij A. N. Patogeneticheskaya mikrobiologia: ru-kovodstvo. [Pathogenetic microbiology: a guide.] Nizhny Novgorod, NizhGMA, Part 2, 2006, 44p. https://medread.ru/patogeneticheskaya-mikrobiologiya-2/44/
62. Khademi F, Vaez H, Momtazi-Borojeni AA, Majnooni A, Banach M, Sahebkar A. Bacterial infections are associated with cardiovascular disease in Iran: a meta-anal-ysis. Arch Med Sci. 2019;15(4):902-911. doi:10.5114/aoms.2019.85509
63. Roggerio A, Sambiase NV, Palomino SA, et al. Correlation of bacterial coinfection versus matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 expression in aortic aneurysm and atherosclerosis. Ann Vasc Surg. 2013;27(7):964-971. doi:10.1016/j.avsg.2013.02.012
64. Weiss TW, Schumacher S, Kaun C, et al. Association between smoking and presence of mycoplasma pneumoniae in circulating leukocytes. Swiss Med Wkly. 2010;140: w13105. Published 2010 Oct 7. doi:10.4414/smw.2010.13105
65. Lansbury L, Lim B, Baskaran V, Lim WS. Co-infections in people with COVID-19: a systematic review and me-ta-analysis [published online ahead of print, 2020 May 27]. J Infect. 2020; S0163-4453(20)30323-6. doi:10.1016/j.jinf.2020.05.046
66. Zahariadis G., Gooley T. A., Ryall P. et al. Risk of ruling out severe acute respiratory syndrome by ruling in another diagnosis: Variable incidence of atypical bacteria coinfection based on diagnostic assays. Can Respir J Vol 13 No 1, p17-22.
67. Fan BE, Lim KGE, Chong VCL, Chan SSW, Ong KH, Kuperan P. COVID-19 and mycoplasma pneumoniae coinfection. Am J Hematol. 2020;95(6):723-724. doi:10.1002/ajh.25785
68. Qin L, Chen Y, You X. Subversion of the Immune Response by Human Pathogenic Mycoplasmas. Front Microbiol. 2019;10:1934. Published 2019 Aug 21. doi:10.3389/fmicb.2019.01934
69. Ipoutcha T, Tsarmpopoulos I, Talenton V, et al. Multiple Origins and Specific Evolution of CRISPR/Cas9 Systems in Minimal Bacteria (Mollicutes). Front Microbiol. 2019;10:2701. Published 2019 Nov 21. doi:10.3389/fmicb.2019.02701
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For citations:
Chikhireva L.N., Cherkashov A.M., Li E.D., Chikhirev O.A., Belenkov Yu.N. Virus-bacterial association of SARS-CoV-2 with mycoplasma as one of the possible causes of severe forms of COVID-19. Experimental and Clinical Gastroenterology. 2020;(7):143-151. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-179-7-143-151
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