The addition of a succinate-containing drug to the treatment improves the clinical and functional state of the liver in patients with community-acquired pneumonia
https://doi.org/10.31146/1682-8658-ecg-181-9-68-72
Abstract
Community-acquired pneumonia is currently one of the most common infectious diseases in the world. At the same time, the inflammation that occurs in community-acquired pneumonia, along with hypoxia, is one of the typical pathological processes that is associated with the introduction of an infecting agent. Under its influence, lipid peroxidation is activated through a cascade of reactions, which contributes to the formation of oxidative stress, accompanied by damage to the structures of various cells, including hepatocytes. The purpose of the study: to evaluate the clinical and functional state of the liver in the treatment of community-acquired pneumonia. Materials and methods: There were 120 people under observation, who were divided into 2 groups, receiving standard therapy for community-acquired pneumonia and patients receiving additional meglumin sodium succinate. The clinical and functional state of the liver was analyzed. Conclusions: when adding meglumin sodium succinate to the treatment of community-acquired pneumonia, the clinical and functional state of the liver in patients improves.
About the Authors
E. S. Bobyleva
The hospital № 8
Russian Federation
Russian Federation
Elena S. Bobyleva, pulmonologist
426034, Izhevsk
A. Yu. Gorbunov
Federal State Budgetary Educational Institution of Higher Education “Izhevsk State Medical Academy” of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Alexander Yu. Gorbunov, Doctor of medical sciences, Associate Professor of the Department of propedeutics of internal diseases with a course of nursing
426034, st. Kommunarov, 281, Izhevsk
References
1. Долгов В. В. Лабораторная диагностика нарушений гемостаза / В. В. Долгов, П. В. Свирин. – М., – 2005. – 221 с. Dolgov V. V. Laboratory diagnostics of disorders of hemostasis. Moscow, 2005. 221 p.
2. Десятовская Ф. С. Этиологическая структура возбудителей внебольничной пневмонии / Ф. С. Де сятов ская, О. П. Цветкова // Бюл. Сев. гос. мед. ун-та. – 2012. – № 1. – С. 139–140. Desyatovskya F. S. Etiological structure of pathogens of community-acquired pneumonia. bull. SEV. state med. Univ. 2012, No. 1, pp. 139–140.
3. Куколь Л. В. Биомаркеры воспаления как критерии оценки тяжести заболевания на амбулаторном этапе с внебольничной пневмонией / Л. В. Куколь, Б. И. Гельцер, А. В. Пупышев // Бюлл. Владивосток. Гос.мед. ун-та. – 2004. – Вып. 17. – С. 79–85. Cockle L. V., Geltser B. I., Pupyshev A. V. Biomarkers of infl ammation as criteria for evaluating the severity of the disease in outpatient community-acquired pneumonia. bull. Vladivostok. State.med. Univ. 2004, Vol. 17, pp. 79–85.
4. Сильвестров В. П. Затяжные пневмонии / Сильвестров В. П., Чучалин А. Г. // Пульмонология. – 2009. – № 3. – С. 5–6. Silvestrov V. P., Chuchalin A. G. of Protracted pneumonia. Pulmonology. 2009, no. 3, pp. 5–6.
5. Чазова И. Е.. Роль легких в метаболизме некоторых маркеров эндотелиального повреждения при нормальном состоянии и при первичной легочной гипертензии / И. Е. Чазова, Т. В. Мартынюк, И. П. Мазенко // Кардиология. –2000. – № 8. –С. 13–15. Chazova I. E., Martynyuk T. V., Mazenko I. P. the role of the lung in the metabolism of some markers of endothelial damage in normal state and in primary pulmonary hypertension. Cardiology. 2000, No. 8, pp. 13–15.
6. Романова Е. Л. Маркеры повреждения эндотелия и провоспалительные цитокины у больных гриппом А/H1N1 / Е. Л. Романова, А. В. Говорин, В. В. Горбунов и др. // Забайкальский медицинский вестник. – 2013. – № 1. – С. 83–87. Romanova E. L., Govorin A. V., Gorbunov V. V., et al. Markers of endothelial damage and Pro-inflammatory cytokines in patients with influenza a/H1N1. Zabaykalsky medical Herald. 2013, No. 1, pp. 83–87.
7. Чучалин А. Г. Внебольничная пневмония у взрослых: практические рекомендации по диагностике, лечению и профилактике / Чучалин А. Г., Си нопаль ников А. И. // Клиническая микробиология, антимикробная терапия, химиотерапия. – 2010. – № 3. – С. 12–15. Chuchalin A. G., Sinopal’nikov A. I. Communityacquired pneumonia in adults: practical recommendations for diagnosis, treatment and prevention. Clinical Microbiology and antimicrobial therapy, chemotherapy. 2010, No. 3, pp. 12–15.
8. Smith M.K., Mooney D. J. Hypoxia leads to necrotic hepatocyte death. Biomed. Mater Res. 2007;80(3):520–529.
9. Батурин В. А. Региональные особенности этиологии внебольничных пневмоний / В. А. Батурин, Е. В. Щетинин // Мед. вестник Сев. Кавказа. – 2006, – № 2, – С. 11–15. Baturin V. A., Shchetinin E. V. Regional peculiarities of the etiology of community-acquired pneumonia. Med. Bulletin of the North. Caucasus. 2006, no. 2, pp. 11–15.
10. Cunningham M. E. Endothelin-1 and endothelun-4 stimulate monocyte production of cytokines. Crit. Care Med. 1997, Vol. 25, pp. 958–964.
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For citations:
Bobyleva E.S., Gorbunov A.Yu. The addition of a succinate-containing drug to the treatment improves the clinical and functional state of the liver in patients with community-acquired pneumonia. Experimental and Clinical Gastroenterology. 2020;(9):68-72. (In Russ.) https://doi.org/10.31146/1682-8658-ecg-181-9-68-72
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