A New Indicator For Assessing The Impact Of Acidic Gastroesophageal Reflux On The Esophageal Mucosa

Abstract

The aim of the study was to evaluate the diagnostic value of the traditional indicators of acidity of daily pH - grams of the esophagus:% of the time from pH<4, the generalized DeMeester index and a new indicator of acidity of daily pH-grams of the esophagus (PCP). Material and methods. The results of the analysis of pH-grams of the stomach and esophagus of patients with pathological parameters of daily pH-metry (DeMeester index >14.72;% of time with pH<4 more than 4.5%) and with normal parameters of daily pH-metry (DeMeester index <14.72;% of time with pH<4 less than 4.5%). As PCU per diem rn-gram of the esophagus is proposed to use the sum of average daily concentrations of H+ ions (mmol/l) are abandoned in the esophagus of reflectata in the range of pH: 0,8-0,9; 1,0-1,9; 2,0-2,9 and 3.0 to 3.9 pH units and the time of exposure of reluctate on the mucosa of the esophagus within the specified ranges of pH of the esophagus. Results. The use of PEP (mmol/l x hour) can provide in the analysis of the per diem rn-grams a more accurate estimate of the influence of pathological and physiological GER in the esophagus due to the use in the calculation of the panel average of the concentrations of H+ ions in the range of pH: 0,8-0,9; 1,0-1,9; 2,0-2,9; 3,0-3,9 and the time of exposure of reluctate on the mucous membrane of the esophagus in each of the specified ranges of pH. Conclusion. The use of the generalized indicator DeMeester and% time with pH<4 may lead to erroneous assessment of the results of the analysis of diurnal pH-gram of the esophagus due to the fact that average daily concentration of H+ ions of reluctate and the exposure time of reluctate on the mucosa of the esophagus within the specified ranges of pH are not included in the definition of the generalized indicator DeMeester and% time with pH<4. It was found that the use of PCP in the analysis of daily pH-grams of the esophagus can provide a more accurate assessment of the impact of pathological and normal SER on the esophageal mucosa.