Antibiotic-Induced Intestinal Dysbiosis And Myocardial Tolerance To Ischemia-Reperfusion Injury In Rats With Different Microbiological Status

Abstract

Aim: assessment of morphological and functional parameters of the isolated heart subjected to global ischemia-reperfusion in conventional and SPF rats with antibiotic-induced intestinal dysbiosis (AID). Materials and methods: experiments were performed on male Wistar rats belonging to conventional and SPF colonies. AID was induced by intragastric administration of clarithromycin and metronidazole during 3 days. Results: SPF animals demonstrated more severe disorders in the evacuatory function of the gastrointestinal tract. In addition, important differences in baseline myocardial function and myocardial tolerance to ischemia-reperfusion were noted between SPF and conventional rats. Conclusion: conventional animals are characterized by increased myocardial tolerance to ischemia-reperfusion injury versus SPF animals, which might be attributed to the presence of chronic low-grade systemic inflammatory response causing activation of cardioprotective signaling in conventional rodents.