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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-168-8-4-10</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-916</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПЕРЕДОВАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LEADING ARTICLE</subject></subj-group></article-categories><title-group><article-title>Канцерогенез у пациентов с неалкогольной жировой болезнью печени без цирроза: роль желчных кислот и кишечной микробиоты</article-title><trans-title-group xml:lang="en"><trans-title>Carcinogenesis in patients with non-alcoholic fatty liver disease without cirrhosis: the role of bile acids and intestinal microbiota</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гриневич</surname><given-names>В. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Grinevich</surname><given-names>V. B.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кравчук</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kravchuk</surname><given-names>Yu. A.</given-names></name></name-alternatives><email xlink:type="simple">kravchuk2003@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Педь</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Ped’</surname><given-names>V. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Арапханова</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Arapkhanova</surname><given-names>M. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шералиев</surname><given-names>А. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Sheraliev</surname><given-names>A. R.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБВОУ ВО «Военно-медицинская академия имени С. М. Кирова» МО РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>S. M. Kirov Military Medical Academy the Russian Defense Ministry</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ «РНЦРХТ им. ак. А.М. Гранова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FBGI «A. M. Granov Russian Research Center of Radiology and Surgical Technologies»</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>20</day><month>08</month><year>2019</year></pub-date><volume>0</volume><issue>8</issue><fpage>4</fpage><lpage>10</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гриневич В.Б., Кравчук Ю.А., Педь В.И., Арапханова М.М., Шералиев А.Р., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Гриневич В.Б., Кравчук Ю.А., Педь В.И., Арапханова М.М., Шералиев А.Р.</copyright-holder><copyright-holder xml:lang="en">Grinevich V.B., Kravchuk Y.A., Ped’ V.I., Arapkhanova M.M., Sheraliev A.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/916">https://www.nogr.org/jour/article/view/916</self-uri><abstract><p>Возникновение гепатоцеллюлярной карциномы у больных с неалкогольной жировой болезнью печени без цирроза приобретает особую актуальность ввиду увеличения количества больных, отсутствия предикторов развития заболевания и его поздней диагностикой. Статья посвящена разбору патогенетических аспектов печеночного канцерогенеза с участием желчных кислот и кишечного микробиома и перспективных направлений в ранней диагностике и возможной профилактике заболевания.</p></abstract><trans-abstract xml:lang="en"><p>The occurrence of hepatocellular carcinoma in patients with non-alcoholic fatty liver disease without cirrhosis is of particular relevance in view of the increasing number of patients, the absence of predictors of the development of the disease and its late diagnosis. The article is devoted to the analysis of pathogenetic aspects of hepatic carcinogenesis with the participation of bile acids and intestinal microbiome and promising directions in early diagnosis and possible prevention of the disease.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>НАЖБП</kwd><kwd>ГЦК</kwd><kwd>желчные кислоты</kwd><kwd>микробиота</kwd><kwd>NAFLD</kwd><kwd>HCC</kwd><kwd>bile acids</kwd><kwd>microbiota</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
