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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-162-2-131-142</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-862</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛЕКЦИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LECTION</subject></subj-group></article-categories><title-group><article-title>Систематический анализ исследований лактитола</article-title><trans-title-group xml:lang="en"><trans-title>Systematic analysis of lactitol studies</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Громова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gromova</surname><given-names>O. A.</given-names></name></name-alternatives><email xlink:type="simple">unesco.gromova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Торшин</surname><given-names>И. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Torshin</surname><given-names>I. Yu.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Максимов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Maximov</surname><given-names>V. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Громов</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Gromov</surname><given-names>A. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рудаков</surname><given-names>К. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rudakov</surname><given-names>K. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФИЦ ИУ РАН, Институт фармакоинформатики, Центр хранения и анализа больших данных (ЦХАБД) МГУ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Big Data Storage and Analysis Center (CCHD), Moscow State University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ДПО Российская медицинская академия непрерывного профессионального образования»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of Further Professional Education “Russian Medical Academy of Continuous Professional Education” of the Ministry of Healthcare of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>20</day><month>02</month><year>2019</year></pub-date><volume>0</volume><issue>2</issue><fpage>131</fpage><lpage>142</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Громова О.А., Торшин И.Ю., Максимов В.А., Громов А.Н., Рудаков К.В., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Громова О.А., Торшин И.Ю., Максимов В.А., Громов А.Н., Рудаков К.В.</copyright-holder><copyright-holder xml:lang="en">Gromova O.A., Torshin I.Y., Maximov V.A., Gromov A.N., Rudakov K.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/862">https://www.nogr.org/jour/article/view/862</self-uri><abstract><p>Лактитол - пребиотический дисахарид, поддерживающий функционирование лакто- и бифидобактерий микробиоты и препятствующий росту патогенной флоры. Результаты транскриптомных и протеомных исследований показали, что лактитол характеризуется уникальными механизмами всасывания и переработки, отличающим его от других пребиотиков. В небольших дозах у детей и взрослых (1…10 г/сут) лактитол проявляет пребиотическое действие; в более высоких дозах (5…50 г/сут) лактитол используется также как осмотическое слабительное. Лактитол усиливает детоксикацию организма (в частности, выведение аммиака и токсичных аминов). Детоксикационный эффект лактитола, отсутствие воздействия лактитола на липидный и гликемический профили крови, отсутствие пищевой непереносимости, редкие побочные эффекты (метеоризм, транзиторная диарея при превышении дозы) делают лактитол важным инструментом в терапии запоров, дисбактериозов, заболеваний печени и печеночной энцефалопатии.</p></abstract><trans-abstract xml:lang="en"><p>Lactitol is a prebiotic disaccharide that supports the functioning of lacto- and bifidobacteria, also inhibits the growth of pathogenic flora. The results of transcriptome and proteomic studies have shown that lactitol is characterized by unique absorption and processing mechanisms in lactobacteriathat distinguish it from other prebiotics. In high doses (5 … 50 g/day) lactiol is used as an osmotic laxative. Lactictol enhances the detoxification of the body (in particular, the excretion of ammonia and toxic amines). The detoxification effect of lactitol, lack of lactitol’seffect on blood lipid and glycemic profiles, lack of food intolerance and rare occurrenceof side effects (flatulence, transient diarrhea when the dose is exceeded) make lactitol an important tool in the treatment of dysbiosis, liver disease and hepatic encephalopathy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>пребиотики</kwd><kwd>запор</kwd><kwd>дисбактериоз</kwd><kwd>систематический анализ</kwd><kwd>лактитол</kwd><kwd>Экспортал</kwd><kwd>dysbiosis</kwd><kwd>systematic analysis</kwd><kwd>lactitol</kwd><kwd>Exportal</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
