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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-157-9-4-9</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-790</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПЕРЕДОВАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LEADING ARTICLE</subject></subj-group></article-categories><title-group><article-title>Биомаркеры воспалительных заболеваний кишечника</article-title><trans-title-group xml:lang="en"><trans-title>Biomarkers of the inflammatory bowel diseases</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козлова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlova</surname><given-names>I. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кудишина</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kudishina</surname><given-names>M. M.</given-names></name></name-alternatives><email xlink:type="simple">aleshechkina-mary@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пахомова</surname><given-names>А. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Pahomova</surname><given-names>A. L.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Саратовский государственный медицинский университет имени В. И. Разумовского» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saratov State Medical University named after V. I. Razumovsky</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>20</day><month>09</month><year>2018</year></pub-date><volume>0</volume><issue>9</issue><fpage>4</fpage><lpage>9</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Козлова И.В., Кудишина М.М., Пахомова А.Л., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Козлова И.В., Кудишина М.М., Пахомова А.Л.</copyright-holder><copyright-holder xml:lang="en">Kozlova I.V., Kudishina M.M., Pahomova A.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/790">https://www.nogr.org/jour/article/view/790</self-uri><abstract><p>Распространенность воспалительных заболеваний кишечника (ВЗК) (язвенного колита (ЯК) и болезни Крона (БК)) ежегодно увеличивается. Актуальными остаются проблемы ранней и неинвазивной диагностики ВЗК. Цель настоящего обзора - анализ диагностической ценности различных биологических маркеров ВЗК. Основная цель поиска новых биомаркеров ВЗК заключена в возможности минимизировать повторные эндоскопические исследования для ранней диагностики и определения активности заболевания, оценки эффективности лечения и профилактики осложнений. Представлены широко используемые, рутинные, а также перспективные биологические маркеры, позволяющие верифицировать диагноз ВЗК, оценить течение и прогноз болезни.</p></abstract><trans-abstract xml:lang="en"><p>The prevalence of inflammatory bowel disease (IBD) (ulcerative colitis (UC) and Crohn's disease (CD)) increases annually. The problems of early and non-invasive diagnosis of IBD remain relevant. The purpose of this review is to analyze the diagnostic value of various biological markers of IBD. The main objective of the search for new biomarkers of IBD is to minimize the possibility of repeated endoscopic studies for early diagnosis and determination of disease activity, evaluation of the effectiveness of treatment and prevention of complications. Widely used, routine, and also perspective biological markers allowing to verify the diagnosis of IBD, to estimate a course and a prognosis of a disease are presented.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>М2-пируваткина</kwd><kwd>матриксные металлопротеиназы (ММП)</kwd><kwd>кальпротектин</kwd><kwd>лактоферрин</kwd><kwd>антинейтрофильные цитоплазматические антитела (ANCA)</kwd><kwd>анти-Saccharomyces cerevisae антитела (ASCA)</kwd><kwd>M2-pyruvate kinase</kwd><kwd>matrix metalloproteinases (MMP)</kwd><kwd>calprotectin</kwd><kwd>lactoferrin</kwd><kwd>antineutrophil cytoplasmic antibodies (ANCA)</kwd><kwd>anti-Saccharomyces cerevisae antibodies ASCA</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
