nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»nogr-673Research ArticleЛЕКЦИЯLECTIONНЕЦЕЛИАКИЙНАЯ ЧУВСТВИТЕЛЬНОСТЬ К ГЛЮТЕНУNONCELIAC SENSITIVITY TO GLUTENКорниенкоЕ. А.KornienkoE. A.elenkornienk@yandex.ruСанкт-Петербургский государственный педиатрический медицинский университетРоссияSaint-Petersburg state pediatric medical UniversityRussian Federation201720032017038998Copyright © Корниенко Е.А., 20172017Корниенко Е.А.Kornienko E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/673

Нецелиакийная чувствительность к глютену (НЦЧГ) - это новый синдром, проявляющийся непереносимостью глютена, это не аллергическое и не аутоиммунное состояние, при котором употребление глютена может приводить к возникновению симптомов, сходных с проявлениями целиакии. Диагноз НЦЧГ требует исключения целиакии и аллергии к пшенице. НЦЧГ проявляется преимущественно кишечными симптомами, которые появляются вскоре после употребления глютен-содержащих продуктов и проходят быстро после отмены глютена. НЦЧГ не сопровождается отставанием в физическом и половом развитии, похуданием и аутоиммунной или аллергической коморбидностью. В основе развития этого синдрома, возможно, лежит влияние измененной микробиоты и метаболитов глютена на нейрорецепторы, а также слабое воспаление слизистой оболочки кишечника без атрофии. НЦЧГ более свойственна взрослым, чем детям, и проявляется чаще в молодом возрасте. В статье представлены дифференциально-диагностические признаки НЦЧГ, целиакии и аллергии к пшенице.

Nonceliac sensitivity to gluten (NCSG) is a new syndrome manifested by a gluten intolerance is not allergic and non-autoimmune condition in which eating gluten can cause symptoms similar to the manifestations of celiac disease. NCSG the diagnosis requires the exclusion of coeliac disease and allergies to wheat. NCSG occurs mainly by intestinal symptoms that appear soon after eating gluten-containing foods and are rapidly after discontinuation of gluten. NCSG is not accompanied by retardation in physical and sexual development, weight loss and autoimmune or allergic comorbidity. The basis for the development of this syndrome probably is the effect of microbiota and metabolites of gluten on the neuroreceptors, as well as a mild inflammation of the intestinal mucosa without atrophy. NCSG more characteristic of adults than children and often manifests at a young age. The article presents the differential diagnostic signs of NCSG, celiac disease and allergies to wheat.

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The authors declare that there are no conflicts of interest present.