nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»nogr-646Research ArticleОБЗОРREVIEWДОБРОКАЧЕСТВЕННЫЕ И ЗЛОКАЧЕСТВЕННЫЕ НОВООБРАЗОВАНИЯ ЖЕЛУДОЧНО-КИШЕЧНОГО ТРАКТА У БОЛЬНЫХ АКРОМЕГАЛИЕЙBENIGN AND MALIGNANT NEOPLASMS OF THE GASTROINTESTINAL TRACT IN PATIENTS WITH ACROMEGALYТитаеваА. А.TitaevaA. A.atitaeva@inbox.ruБелоусоваЕ. А.BelousovaE. A.noemail@neicon.ruТерещенкоС. Г.TereshchenkoS. G.noemail@neicon.ruГБУЗ МО МОНИКИ им. М. Ф. ВладимирскогоРоссияMoscow regional scientific and clinical research Institute named after M. F. VladimirskyRussian Federation201820062018069497Copyright © Титаева А.А., Белоусова Е.А., Терещенко С.Г., 20182018Титаева А.А., Белоусова Е.А., Терещенко С.Г.Titaeva A.A., Belousova E.A., Tereshchenko S.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/646

Акромегалия - тяжелое нейроэндокринное заболевание, вызываемое повышенной продукцией соматотропного гормона опухолью аденогипофиза. Соматотропный гормон опосредованно, через инсулиноподобный фактор роста-1, действует на все органы и системы организма, вызывая большое количество осложнений, в том числе и со стороны желудочно-кишечного тракта. В литературе описаны многочисленные случаи диагностирования как доброкачественных, так и злокачественных новообразований у данной группы пациентов. Около 15% больных акромегалией умирают от онкологических заболеваний, в первую очередь рака толстой кишки, частота которого варьирует от 2 до 14кратного увеличения по сравнению с общей популяцией. Однако, исследований верхнего отдела пищеварительного тракта у больных акромегалией крайне мало. В статье отражены результаты различных отечественных и зарубежных исследований, касающихся верхнего и нижнего отделов желудочно-кишечного тракта у больных акромегалией, злокачественных и доброкачественных новообразований желудка и толстой кишки, дивертикулярной болезни у больных акромегалией, а также возможные предпосылки их развития, исходя из патогенеза основного заболевания.

Acromegaly is a severe neuroendocrine disease caused by increased production of somatotropic hormone by adenohypophysis tumor. The somatotropic hormone is indirectly, via insulin-like growth factor-1, acts on all organs and systems of the body, causing a large number of complications, including those of the gastrointestinal tract. Numerous cases of diagnosing both benign and malignant neoplasms have been described in the literature in this group of patients. About 15% of patients with acromegaly die from cancer, especially colon cancer, which frequency varies from 2 to 14 times the increase in comparison with the general population. However, there is an extremely low amount of studies of the upper part of the digestive tract in patients with acromegaly. The article reflects the results of various domestic and foreign studies on the upper and lower divisions of the gastrointestinal tract of patients with acromegaly, malignant and benign neoplasms of the stomach and colon, diverticular disease in patients with acromegaly, as well as possible prerequisites for their development, based on the pathogenesis of the underlying disease.

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The authors declare that there are no conflicts of interest present.