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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">nogr-584</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПЕРЕДОВАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LEADING ARTICLE</subject></subj-group></article-categories><title-group><article-title>ЗУБЧАТЫЕ ОБРАЗОВАНИЯ ТОЛСТОЙ КИШКИ: ЭНДОСКОПИЧЕСКАЯ ДИАГНОСТИКА, РОЛЬ В КОЛОРЕКТАЛЬНОМ КАНЦЕРОГЕНЕЗЕ</article-title><trans-title-group xml:lang="en"><trans-title>THE SERRATED NEOPLASMS OF THE COLON: ENDOSCOPIC DIAGNOSIS, THE ROLE IN COLORECTAL CARCINOGENESIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зобнина</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zobnina</surname><given-names>M. V.</given-names></name></name-alternatives><email xlink:type="simple">dudka-m@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карасев</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Karasev</surname><given-names>I. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черкес</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Cherkes</surname><given-names>L. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Туманян</surname><given-names>А. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Tumanyan</surname><given-names>A. O.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малихов</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Malikhov</surname><given-names>A. G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малихова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Malikhova</surname><given-names>O. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>НМИЦ Онкологии им. Н.Н, Блохина Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>SMRC Oncology. N. N. Blokhin</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>20</day><month>04</month><year>2018</year></pub-date><volume>0</volume><issue>4</issue><fpage>4</fpage><lpage>8</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Зобнина М.В., Карасев И.А., Черкес Л.В., Туманян А.О., Малихов А.Г., Малихова О.А., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Зобнина М.В., Карасев И.А., Черкес Л.В., Туманян А.О., Малихов А.Г., Малихова О.А.</copyright-holder><copyright-holder xml:lang="en">Zobnina M.V., Karasev I.A., Cherkes L.V., Tumanyan A.O., Malikhov A.G., Malikhova O.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/584">https://www.nogr.org/jour/article/view/584</self-uri><abstract><p>В последние годы отмечается тенденция к неуклонному росту заболеваемости колоректальным раком (КРР): прирост абсолютного числа заболевших раком ободочной кишки с 2009 года по 2015 год составил 11,3%; раком прямой кишки - 9,9%. В структуре смертности населения от злокачественных новообразований КРР в нашей стране занимает второе место, уступая лишь раку легкого. Данное обстоятельство обусловлено тем, что при первичном обращении пациентов к врачу запущенные формы рака (III-IV стадии) диагностируются у 71,4% больных раком ободочной кишки и у 62,4% в случаях заболевания раком прямой кишки. Столь поздняя диагностика связана прежде всего с отсутствием соответствующей федеральной скрининговой программы, а также с неосведомленностью медицинских работников в современных представлениях о толстокишечном канцерогенезе и предопухолевых изменениях слизистой оболочки толстой кишки.</p></abstract><trans-abstract xml:lang="en"><p>In recent years, there has been a trend towards a steady increase in the incidence of colorectal cancer (CRC): the increase in the absolute number of patients with colon cancer from 2009 to 2015 amounted to 11.3%; rectal cancer - 9.9%. In the structure of mortality from malignant tumors of the KRR in our country takes the second place, second only to lung cancer. This fact is due to the fact, that the primary treatment of patients to the doctor advanced forms of cancer (III-IV stage) are diagnosed in 71.4% of patients with colon cancer and 62.4% in cases of rectal cancer. Such a late diagnosis is primarily due to the lack of an appropriate Federal screening program, as well as to the lack of awareness of medical workers in modern ideas about colonic carcinogenesis and precancerous changes in the mucous membrane of the colon.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>колоректальный рак (КРР)</kwd><kwd>зубчатые образования</kwd><kwd>эндоскопическая диагностика</kwd><kwd>зубчатый путь развития КРР</kwd></kwd-group><kwd-group xml:lang="en"><kwd>colorectal cancer (CRC)</kwd><kwd>gear education</kwd><kwd>endoscopy</kwd><kwd>diagnostics</kwd><kwd>gear the path of development of CRC</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Seigel R., Naishadham D., Jemal A. «Cancer Statistics, 2013» // CA cancer j. clin. - 2013 - Vol. - 63 - P. 11-30</mixed-citation><mixed-citation xml:lang="en">Seigel R., Naishadham D., Jemal A. «Cancer Statistics, 2013» // CA cancer j. clin. - 2013 - Vol. - 63 - P. 11-30</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Pathology and Genetics of Tumours of the Digestive System (IARC WHO Classification of Tumours)// World Health Organization; (October 2010)</mixed-citation><mixed-citation xml:lang="en">Pathology and Genetics of Tumours of the Digestive System (IARC WHO Classification of Tumours)// World Health Organization; (October 2010)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Давыдов М. 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