nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»nogr-579Research ArticleОБЗОРREVIEWФАКТОРЫ РИСКА РАКА ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ: ОБЗОР МЕТА-АНАЛИЗОВ И ПРОСПЕКТИВНЫХ КОГОРТНЫХ ИССЛЕДОВАНИЙ ЧАСТЬ 1. ПОТРЕБЛЕНИЕ КОФЕ И ЧАЯPANCREATIC CANCER RISK FACTORS: A SUMMARY REVIEW OF META-ANALYTICAL AND PROSPECTIVE COHORT STUDIES PART 1. COFFEE AND TEA CONSUMPTIONГригорьеваИ. Н.GrigorievaI. N.noemail@neicon.ruНаучно-исследовательский институт терапии и профилактической медицины - филиал Федерального государственного бюджетного научного учреждения «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук»; Новосибирский национальный исследовательский государственный университетРоссияResearch Institutе of Internal and Preventive Medicine - Branch of Federal State Budget Scientefic Institution The Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences; National Research State UniversityRussian Federation201820032018039396Copyright © Григорьева И.Н., 20182018Григорьева И.Н.Grigorieva I.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/579

Рак поджелудочной железы (РПЖ) является одной из пяти причин смертности от рака. Роль диетических факторов в этиологии РПЖ неясна. Мы рассмотрели некоторые мета-анализы, касающиеся взаимосвязи между потреблением кофе (К) и потреблением чая (Ч) и риском РПЖ. Компоненты К могут оказывать антиканцерогенное действие: мета-анализ Dong (2011) подтвердил, что объединенный относительный риск (RR) РПЖ у любителей К, сравниваемый с непьющими К, составлял 0,68 (95% ДИ 0,51-0,84). Но в исследовании «US NIH-AARP Diet and Health Study» (2015) после корректировки на курение риск РПЖ был незначимым: HR=1,24 (0,93-1,65) при сравнении непьющих К и потребителей К≥6 чашек в день (чвд). В Европейском проспективном исследовании (2013) ни К, ни Ч также не были связаны с риском РПЖ, но в предыдущем итальянском многоцентровом исследовании (1995) было показано, что потребление > 3 чвд приводит к значительному росту риска РПЖ (отношение шансов (OR) 2,53, 1,53-4,18). Мета-анализ Zeng (2014) показал, что потребление зеленого Ч> 2 чвд (OR0,95, 0,85-1,06) не связано с риском РПЖ. Несмотря на это, в мета-анализе Chen (2014) анализ подгрупп по разным странам показал, что в китайской популяции при высоком потреблении Ч достоверно снижался риск РПЖ (Risk ratio = 0,76, 0,59-0,98). Необходимо учитывать, что мета-анализы, исследования «случай-контроль» подвержены некоторым ограничениям: системные ошибки при опросе, создании выборки, например, разные диетические порции, корректировка по различным факторам и т. д. Требуются дальнейшие исследования для уточнения биологических механизмов возможной обратной зависимости между потреблением К, Ч и риском РПЖ

Pancreatic cancer (PC) is one of the top 5 causes of mortality from cancer. The role of dietary factors in the etiology of PC is unclear. We reviewed some meta-analytical or pooled reports dealing with the association between coffee (C) and tea (T) consumption and PC risk. C components can have anticarcinogenic effect: meta-analysis by Dong (2011) confirmed, that pooled relative risk (RR) of PC in high C lovers comparing with non/lowest C drinkers was 0.68 (95% CI 0.51-0.84). But in the “US NIH-AARP Diet and Health Study” (2015) after adjustment for smoking, PC risk were not significant: never C drinkers compared with C drinkers≥6 cups per day (cpd) HR1.24 (0.93-1.65). In the European Prospective Investigation (2013) neither C, nor T were also associated with PC risk, but the previous Italian multicenter study (1995) was demonstrated, that ingestion of >3 cpd lead to significantly increased PC risk (odds ratio (OR) 2.53; 1.53-4.18). A meta-analysis by Zeng (2014) indicate, that green T consumption >2 cpd (OR0.95, 0.85-1.06) was not associated with PC risk. However, the subgroup analysis of different countries in meta-analysis by Chen (2014) showed a statistical decrease in PC risk by high T consumption in a Chinese population (Risk ratio=0.76, 0.59-0.98). Nevertheless meta-analysis, pooled and case-control studies are prone to some limitations (recall, selection bias) - different dietary patterns, adjustment for different confounders, etc. Further research is needed to clarify the biological mechanisms in the possible inverse relationship between C, T intake and PC risk.

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The authors declare that there are no conflicts of interest present.