nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»nogr-567Research ArticleПЕРЕДОВАЯ СТАТЬЯLEADING ARTICLEРЕКОМЕНДАЦИИ ПО ПРОФИЛАКТИКЕ И ЛЕЧЕНИЮ ЭЗОФАГО-ГАСТРО-ЭНТЕРО-КОЛОПАТИЙ, ИНДУЦИРОВАННЫХ НЕСТЕРОИДНЫМИ ПРОТИВОВОСПАЛИТЕЛЬНЫМИ ПРЕПАРАТАМИRECOMMENDATIONS FOR THE PREVENTION AND TREATMENT OF ESOPHAGO-GASTRO-ENTERO-COLOPATHY INDUCED BY NONSTEROIDAL ANTIINFLAMMATORY DRUGS “NSAID”ЛазебникЛ. Б.LazebnikL. B.noemail@neicon.ruГоловановаЕ. В.GolovanovaE. V.noemail@neicon.ruАлексеенкоС. А.AlekseenkoS. A.noemail@neicon.ruБакулинаН. В.BakulinaN. V.noemail@neicon.ruБарановскийА. Ю.BaranovskyA. Yu.noemail@neicon.ruБеловаГ. В.BelovaG. V.noemail@neicon.ruБординД. С.BordinD. S.noemail@neicon.ruВьючноваЕ. С.VyupkinaE. S.noemail@neicon.ruГайдуковаИ. З.GaidukovaI. Z.noemail@neicon.ruГимаеваЗ. Ф.GimaevaZ. F.noemail@neicon.ruКашкинаЕ. И.KashkinaE. I.noemail@neicon.ruКозловаИ. В.KozlovaI. V.noemail@neicon.ruКокоринВ. А.KokorinV. A.noemail@neicon.ruЛапинаЕ. Д.LapinaE. D.noemail@neicon.ruЛиЕ. Д.LeeE. D.noemail@neicon.ruМигуськинаЕ. И.MiguskinaE. I.noemail@neicon.ruМирончевО. В.MironchevO. V.noemail@neicon.ruОнучинаЕ. В.OnuchinaE. V.noemail@neicon.ruОхлобыстинА. В.OkhlobystinA. V.noemail@neicon.ruПасечниковВ. Д.PasechnikovV. D.noemail@neicon.ruПахомоваИ. Г.PakhomovaI. G.noemail@neicon.ruПоздняковаО. Ю.PozdnyakovaO. Yu.noemail@neicon.ruПутинцеваИ. В.PutintsevaI. V.noemail@neicon.ruСарсенбаеваА. С.SarsenbaevaA. S.noemail@neicon.ruСвиридоваТ. Н.SviridovaT. N.noemail@neicon.ruСиманенковВ. И.SimanenkovV. I.noemail@neicon.ruСимоноваЖ. Г.SimonovaZh. G.noemail@neicon.ruСиткинС. И.SitkinS. I.noemail@neicon.ruТкаченкоЕ. И.TkachenkoE. I.noemail@neicon.ruТуркинаС. В.TurkinaS. V.noemail@neicon.ruХабароваЮ. А.KhabarovaYu. A.noemail@neicon.ruШевяковМ. А.ShevyakovM. A.noemail@neicon.ruЯковенкоЭ. П.YakovenkoE. P.noemail@neicon.ruЯковлевА. А.YakovlevA. A.noemail@neicon.ruЯнковаяТ. Н.YankovayaT. N.noemail@neicon.ruМосковский государственный медико-стоматологический университет им. А. И. ЕвдокимоваРоссияMoscow State University of Medicine and Dentistry named after A. I. EvdokimovRussian FederationДальневосточный государственный медицинский университет (ДВГМУ)РоссияFar-Eastern State Medical UniversityRussian FederationСеверо-Западный государственный медицинский университет им. И. И. МечниковаРоссияState Medical University named after I. I. Mechnikov of Russian Federation Ministry of Public HealthRussian FederationНаучно-клинический и образовательный центр гастроэнтерологии и гепатологии Санкт-Петербургского государственного университетаРоссияScientifi c and clinical center of gastroenterology and HepatologyRussian FederationМногопрофильный медицинский центр Центрального Банка Российской ФедерацииРоссияMultidisciplinary Medical Center of the Central Bank of the Russian FederationRussian FederationМосковский клинический научный центр (МКНЦ)РоссияMoscow Clinical and Research CenterRussian FederationСаратовский ГМУ им. В. И. Разумовского Минздрава России; Башкирский государственный медицинский университетРоссияSaratov State Medical University n. a. V. I. Razumovsky of Ministry of Healthcare of Russian FederationRussian FederationБашкирский государственный медицинский университетРоссияBashkir State Medical UniversityRussian FederationРоссийский национальный исследовательский медицинский университет имени Н. И. ПироговаРоссияPirogov Russian National Research Medical UniversityRussian FederationГосударственная Новосибирская областная клиническая больницаРоссияState Novosibirsk Regional Clinical HospitalRussian FederationОренбургский государственный медицинский университетРоссияOrenburg State Medical UniversityRussian FederationИркутская государственная академия последипломного образованияРоссияIrkutsk State Academy of Postgraduate EducationRussian FederationПервый Московский государственный медицинский университет имени И. М. Сеченова Министерства здравоохранения Российской ФедерацииРоссияFederal State Autonomous Educational Institution of Higher Education I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian FederationRussian FederationСтавропольский государственный медицинский университетРоссияStavropol State Medical UniversityRussian FederationКрасноярский государственный медицинский университет имени профессора В. Ф. Войно-Ясенецкого МЗ РФРоссияKrasnoyarsk State Medical University named after Prof. V. F. Voino-YasenetskyRussian FederationЮжно-Уральский государственный медицинский университетРоссияChelyabinsk State Medical Academy of Federal Agency of Health Care and Social DevelopmentRussian FederationВоронежский государственный медицинский университет им. Н. Н. БурденкоРоссияVoronezh State Medical University named after N. N. BurdenkoRussian FederationКировский государственный медицинский университет Минздрава РоссииРоссияKirov state medical university under the Ministry of Health of the Russian FederationRussian FederationВолгоградский государственный медицинский университетРоссияThe Volgograd State Medical University of Public Health Ministry of the Russian FederationRussian FederationСеверный государственный медицинский университетРоссияNorthern State Medical UniversityRussian FederationРостовский государственный медицинский университетРоссияFederal State Budgetary Educational Institution of Higher Education «Rostov State Medical University» of the Ministry of Healthcare of the Russian FederationRussian FederationГОУ ВПО СГМА РосздраваРоссияSmolensk state medical universityRussian Federation20182003201803418Copyright © Лазебник Л.Б., Голованова Е.В., Алексеенко С.А., Бакулина Н.В., Барановский А.Ю., Белова Г.В., Бордин Д.С., Вьючнова Е.С., Гайдукова И.З., Гимаева З.Ф., Кашкина Е.И., Козлова И.В., Кокорин В.А., Лапина Е.Д., Ли Е.Д., Мигуськина Е.И., Мирончев О.В., Онучина Е.В., Охлобыстин А.В., Пасечников В.Д., Пахомова И.Г., Позднякова О.Ю., Путинцева И.В., Сарсенбаева А.С., Свиридова Т.Н., Симаненков В.И., Симонова Ж.Г., Ситкин С.И., Ткаченко Е.И., Туркина С.В., Хабарова Ю.А., Шевяков М.А., Яковенко Э.П., Яковлев А.А., Янковая Т.Н., 20182018Лазебник Л.Б., Голованова Е.В., Алексеенко С.А., Бакулина Н.В., Барановский А.Ю., Белова Г.В., Бордин Д.С., Вьючнова Е.С., Гайдукова И.З., Гимаева З.Ф., Кашкина Е.И., Козлова И.В., Кокорин В.А., Лапина Е.Д., Ли Е.Д., Мигуськина Е.И., Мирончев О.В., Онучина Е.В., Охлобыстин А.В., Пасечников В.Д., Пахомова И.Г., Позднякова О.Ю., Путинцева И.В., Сарсенбаева А.С., Свиридова Т.Н., Симаненков В.И., Симонова Ж.Г., Ситкин С.И., Ткаченко Е.И., Туркина С.В., Хабарова Ю.А., Шевяков М.А., Яковенко Э.П., Яковлев А.А., Янковая Т.Н.Lazebnik L.B., Golovanova E.V., Alekseenko S.A., Bakulina N.V., Baranovsky A.Y., Belova G.V., Bordin D.S., Vyupkina E.S., Gaidukova I.Z., Gimaeva Z.F., Kashkina E.I., Kozlova I.V., Kokorin V.A., Lapina E.D., Lee E.D., Miguskina E.I., Mironchev O.V., Onuchina E.V., Okhlobystin A.V., Pasechnikov V.D., Pakhomova I.G., Pozdnyakova O.Y., Putintseva I.V., Sarsenbaeva A.S., Sviridova T.N., Simanenkov V.I., Simonova Z.G., Sitkin S.I., Tkachenko E.I., Turkina S.V., Khabarova Y.A., Shevyakov M.A., Yakovenko E.P., Yakovlev A.A., Yankovaya T.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/567нестероидные противовоспалительные препаратыантитромботические препаратыбезрецептурные препаратыгастроэнтеропатиягастроэнтеропротекторные средстваингибиторы протонной помпыпростагландин Е2Н2-блокаторы гистаминовых рецепторовnonsteroidal anti-inflammatory drugsantithromboticsOTC drugsgastroenteropathygastroenteroprotective agentsproton pump inhibitorsprostaglandin E2H2-blockers of histamine receptorsReferencesConaghan P.G. A turbulent decade for NSAIDs: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity. Rheumatology International. 2012;32(6):1491-1502. doi:10.1007/s00296-011-2263-6.Conaghan P.G. A turbulent decade for NSAIDs: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity. Rheumatology International. 2012;32(6):1491-1502. doi:10.1007/s00296-011-2263-6.Peura D.A. Gastrointestinal safety and tolerability of nonselective nonsteroidal anti-inflammatory agents and cyclooxygenase-2-selective inhibitors. Cleve Clin J Med. 2002;69Suppl 1: SI31-9.Peura D.A. Gastrointestinal safety and tolerability of nonselective nonsteroidal anti-inflammatory agents and cyclooxygenase-2-selective inhibitors. Cleve Clin J Med. 2002;69Suppl 1: SI31-9.Koffeman A.R, Valkhoff V.E, Çelik S. et al. High-risk use of over-the-counter non-steroidal anti-inflammatory drugs: a population-based cross-sectional study. The British Journal of General Practice. 2014;64(621).Koffeman A.R, Valkhoff V.E, Çelik S. et al. High-risk use of over-the-counter non-steroidal anti-inflammatory drugs: a population-based cross-sectional study. The British Journal of General Practice. 2014;64(621).Khan S, Mohammad A, O’Rourke K.P. An audit of the frequency of proton pump inhibitor (PPI) prescription in rheumatoid arthritis (RA) patients taking non-steroidal anti-inflammatory drugs (NSAIDs). Ir J MedSci. 2014 Dec;183(4):685-6.Khan S, Mohammad A, O’Rourke K.P. An audit of the frequency of proton pump inhibitor (PPI) prescription in rheumatoid arthritis (RA) patients taking non-steroidal anti-inflammatory drugs (NSAIDs). Ir J MedSci. 2014 Dec;183(4):685-6.Takeuchi K. Pathogenesis of NSAID-induced gastric damage: Importance of cyclooxygenase inhibition and gastric hypermotility. World Journal of Gastroenterology: WJG. 2012; 18 (18): 2147-2160.Takeuchi K. Pathogenesis of NSAID-induced gastric damage: Importance of cyclooxygenase inhibition and gastric hypermotility. World Journal of Gastroenterology: WJG. 2012; 18 (18): 2147-2160.Unified Clinical Protocol for Primary and Secondary Medical Care Peptic Ulcer of Stomach and Duodenum in Adults, Ukraine [September, 2014]Unified Clinical Protocol for Primary and Secondary Medical Care Peptic Ulcer of Stomach and Duodenum in Adults, Ukraine [September, 2014]Russian gastroenterological association clinical guidelines on diagnosis and treatment of NSAIDs-associated erosive and ulcerative lesions of the stomach and duodenum [Moscow, 2014]Russian gastroenterological association clinical guidelines on diagnosis and treatment of NSAIDs-associated erosive and ulcerative lesions of the stomach and duodenum [Moscow, 2014]Abraham N.S, Hlatky M.A, Antman E.M, Bhatt D.L, Bjorkman D.J, Clark C.B, et al. ACCF/ACG/AHA 2010 Expert Consensus Document on the Concomitant Use of Proton Pump Inhibitors and Thienopyridines: A Focused Update of the ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use. Am J Gastroenterol. 2010 Dec;105(12):2533-49.Abraham N.S, Hlatky M.A, Antman E.M, Bhatt D.L, Bjorkman D.J, Clark C.B, et al. ACCF/ACG/AHA 2010 Expert Consensus Document on the Concomitant Use of Proton Pump Inhibitors and Thienopyridines: A Focused Update of the ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use. Am J Gastroenterol. 2010 Dec;105(12):2533-49.Lanza F.L, Chan F.K, Quigley E.M; Practice Parameters Committee of the American College of Gastroenterology. Guidelines for prevention of NSAID-related ulcer complications. Am J Gastroenterol 2009; 104:728-738Lanza F.L, Chan F.K, Quigley E.M; Practice Parameters Committee of the American College of Gastroenterology. Guidelines for prevention of NSAID-related ulcer complications. Am J Gastroenterol 2009; 104:728-738NICE Guidelines: Acute upper gastrointestinal bleeding in over 16s: management. Доступ по ссылке https://www.nice.org.uk/guidance/cg141 Последний доступ: 15 сентября 2016 г.NICE Guidelines: Acute upper gastrointestinal bleeding in over 16s: management. Доступ по ссылке https://www.nice.org.uk/guidance/cg141 Последний доступ: 15 сентября 2016 г.Unified Clinical Protocol for Primary Medical Care Dyspepsia, Ukraine [August,2012]Unified Clinical Protocol for Primary Medical Care Dyspepsia, Ukraine [August,2012]Rostom A, Moayyedi P, Hunt R. Canadian Association of Gastroenterology Consensus Group. Canadian consensus guidelines on long-term nonsteroidal anti-inflammatory drug therapy and the need for gastroprotection: benefits versus risks [2008]. AlimentPharmacolTher. 2009 Mar 1;29(5):481-96.Rostom A, Moayyedi P, Hunt R. Canadian Association of Gastroenterology Consensus Group. Canadian consensus guidelines on long-term nonsteroidal anti-inflammatory drug therapy and the need for gastroprotection: benefits versus risks [2008]. AlimentPharmacolTher. 2009 Mar 1;29(5):481-96.Allison M.C, Howatson A.G, Torrance C.J, et al. Gastrointestinal damage associated with the use of nonsteroidal anti-inflammatory drugs. N Engl J Med 1992; 327:749-54.Allison M.C, Howatson A.G, Torrance C.J, et al. Gastrointestinal damage associated with the use of nonsteroidal anti-inflammatory drugs. N Engl J Med 1992; 327:749-54.Angel Lanas, Maarten Boers, Javier Nuevo. Gastrointestinal events in at-risk patients starting non-steroidal anti-inflammatory drugs (NSAIDs) for rheumatic diseases: the EVIDENCE study of European routine practice. AnnRheumDis 2015; 74:675-681.Angel Lanas, Maarten Boers, Javier Nuevo. Gastrointestinal events in at-risk patients starting non-steroidal anti-inflammatory drugs (NSAIDs) for rheumatic diseases: the EVIDENCE study of European routine practice. AnnRheumDis 2015; 74:675-681.García Rodríguez L.A, Barreales Tolosa L (2007) Risk of upper gastrointestinal complications among users of traditional NSAIDs and COXIBs in the general population. Gastroenterology 132:498-506.García Rodríguez L.A, Barreales Tolosa L (2007) Risk of upper gastrointestinal complications among users of traditional NSAIDs and COXIBs in the general population. Gastroenterology 132:498-506.Moskowitz R.W, Abramson S.B, Berenbaum F, Simon L.S, Hochberg M (2007) Coxibs and NSAIDs-is the air any clearer? Perspectives from the OARSI/International COX-2 Study Group Workshop 2007. OsteoarthrCartil 15:849-856.Moskowitz R.W, Abramson S.B, Berenbaum F, Simon L.S, Hochberg M (2007) Coxibs and NSAIDs-is the air any clearer? Perspectives from the OARSI/International COX-2 Study Group Workshop 2007. OsteoarthrCartil 15:849-856.Makris, U., Kohler, M., &Fraenkel, L. (2010). Adverse Effects (AEs) of Topical NSAIDs in Older Adults with Osteoarthritis (OA): a Systematic Review of the Literature. TheJournalofRheumatology, 37(6), 1236-1243.Makris, U., Kohler, M., &Fraenkel, L. (2010). Adverse Effects (AEs) of Topical NSAIDs in Older Adults with Osteoarthritis (OA): a Systematic Review of the Literature. TheJournalofRheumatology, 37(6), 1236-1243.Castellsague, J., Riera-Guardia, N., Calingaert, B., Varas-Lorenzo, C., Fourrier-Reglat, A., Nicotra, F., … Safety of Non-Steroidal Anti-Inflammatory Drugs (SOS) Project. (2012). Individual NSAIDs and Upper Gastrointestinal Complications: A Systematic Review and Meta-Analysis of Observational Studies (the SOS Project). Drug Safety, 35(12), 1127-1146.Castellsague, J., Riera-Guardia, N., Calingaert, B., Varas-Lorenzo, C., Fourrier-Reglat, A., Nicotra, F., … Safety of Non-Steroidal Anti-Inflammatory Drugs (SOS) Project. (2012). Individual NSAIDs and Upper Gastrointestinal Complications: A Systematic Review and Meta-Analysis of Observational Studies (the SOS Project). Drug Safety, 35(12), 1127-1146.Garg A, Shoeb A, Moodahadu L.S, Sharma A, Gandhi A, and Akku S. Amtolmetin: A Reappraisal of NSAID with Gastroprotection. Arthritis. 2016; 2016: 7103705.Garg A, Shoeb A, Moodahadu L.S, Sharma A, Gandhi A, and Akku S. Amtolmetin: A Reappraisal of NSAID with Gastroprotection. Arthritis. 2016; 2016: 7103705.Munro H.M, Walton S.R, Malviya S, Merkel S, Voepel-Lewis T, Loder RT, Farley F.A. Low-dose ketorolac improves analgesia and reduces morphine requirements following posterior spinal fusion in adolescents. Can J Anaesth. 2002 May;49(5):461-6.Munro H.M, Walton S.R, Malviya S, Merkel S, Voepel-Lewis T, Loder RT, Farley F.A. Low-dose ketorolac improves analgesia and reduces morphine requirements following posterior spinal fusion in adolescents. Can J Anaesth. 2002 May;49(5):461-6.Fries JF, Williams CA, Bloch DA et al. Nonsteroidal anti-inflammatory drug- associated gastropathy: incidence and risk factor models. Am J Med 1991; 91: 213-22.Fries JF, Williams CA, Bloch DA et al. Nonsteroidal anti-inflammatory drug- associated gastropathy: incidence and risk factor models. Am J Med 1991; 91: 213-22.Gabriel SE, Jaakkimainen L, Bombardier C. Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs. A meta-analysis. AnnInternMed 1991; 115:787-96.Gabriel SE, Jaakkimainen L, Bombardier C. Risk for serious gastrointestinal complications related to use of nonsteroidal anti-inflammatory drugs. A meta-analysis. AnnInternMed 1991; 115:787-96.Koch M, Dezi A, Tarquini M, Capurso L. Prevention of non-steroidal anti-inflammatory drug-induced gastrointestinal mucosal injury: risk factors for serious complications. DigLiverDis. 2000 Mar;32(2):138-51.Koch M, Dezi A, Tarquini M, Capurso L. Prevention of non-steroidal anti-inflammatory drug-induced gastrointestinal mucosal injury: risk factors for serious complications. DigLiverDis. 2000 Mar;32(2):138-51.Cardile S, Martinelli M, Barabino A, Gandullia P, Oliva S, Nardo G et al. Italian survey on non-steroidal anti-inflammatory drugs and gastrointestinal bleeding in children. World J Gastroenterol. 2016 Feb 7; 22(5): 1877-1883.Cardile S, Martinelli M, Barabino A, Gandullia P, Oliva S, Nardo G et al. Italian survey on non-steroidal anti-inflammatory drugs and gastrointestinal bleeding in children. World J Gastroenterol. 2016 Feb 7; 22(5): 1877-1883.Derry S, Loke YK. Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis. BMJ. 2000 Nov 11;321(7270):1183-7Derry S, Loke YK. Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis. BMJ. 2000 Nov 11;321(7270):1183-7Iijima K, Koike T, Ara N, Nakagawa K, Kondo Y, Uno K, Hatta W, Asano N, Imatani A, Shimosegawa T. Identification of a high-risk group for low-dose aspirin-induced gastropathy by measuring serum pepsinogen in H. pylori-infected subjects. J Gastroenterol. 2015 Mar;50(3):305-12Iijima K, Koike T, Ara N, Nakagawa K, Kondo Y, Uno K, Hatta W, Asano N, Imatani A, Shimosegawa T. Identification of a high-risk group for low-dose aspirin-induced gastropathy by measuring serum pepsinogen in H. pylori-infected subjects. J Gastroenterol. 2015 Mar;50(3):305-12Yeomans N.D, Lanas A.I, Talley N.J, Thomson A.B, Daneshjoo R, Eriksson B, Appelman-Eszczuk S, Långström G, Naesdal J, Serrano P, et al. Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin. Aliment PharmacolTher. 2005; 22:795-801.Yeomans N.D, Lanas A.I, Talley N.J, Thomson A.B, Daneshjoo R, Eriksson B, Appelman-Eszczuk S, Långström G, Naesdal J, Serrano P, et al. Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin. Aliment PharmacolTher. 2005; 22:795-801.Narum S, Westergren T, Klemp M. Corticosteroids and risk of gastrointestinal bleeding: a systematic review and meta-analysis. BMJ Open 2014; 4: e004587.Narum S, Westergren T, Klemp M. Corticosteroids and risk of gastrointestinal bleeding: a systematic review and meta-analysis. BMJ Open 2014; 4: e004587.Chang H.Y, Zhou M, Tang W, Alexander G.C, Singh S. Risk of gastrointestinal bleeding associated with oral anticoagulants: population based retrospective cohort study. BMJ. 2015 Apr 24;350: h1585.Chang H.Y, Zhou M, Tang W, Alexander G.C, Singh S. Risk of gastrointestinal bleeding associated with oral anticoagulants: population based retrospective cohort study. BMJ. 2015 Apr 24;350: h1585.Mort JR, Aparasu RR, Baer RK. Interaction between selective serotonin reuptake inhibitors and nonsteroidal antiinflammatory drugs: review of the literature. Pharmacotherapy. 2006 Sep;26(9):1307-13.Mort JR, Aparasu RR, Baer RK. Interaction between selective serotonin reuptake inhibitors and nonsteroidal antiinflammatory drugs: review of the literature. Pharmacotherapy. 2006 Sep;26(9):1307-13.Vonkeman HE, deLeest H, van deLaar M, et al. Assessment of Helicobacter pylori eradication in patients on NSAID treatment. BMC Gastroenterology. 2012; 12:133.Vonkeman HE, deLeest H, van deLaar M, et al. Assessment of Helicobacter pylori eradication in patients on NSAID treatment. BMC Gastroenterology. 2012; 12:133.Kono Y, Okada H, Takenaka R, et al. Does Helicobacter pylori Exacerbate Gastric Mucosal Injury in Users of Nonsteroidal Anti-Inflammatory Drugs? A Multicenter, Retrospective, Case-Control Study. Gut and Liver. 2016;10(1):69-75.Kono Y, Okada H, Takenaka R, et al. Does Helicobacter pylori Exacerbate Gastric Mucosal Injury in Users of Nonsteroidal Anti-Inflammatory Drugs? A Multicenter, Retrospective, Case-Control Study. Gut and Liver. 2016;10(1):69-75.Sokic-Milutinovic A, Krstic M, Rozer-Smolovic B, Alempijevic T. Role of Helicobacter pylori infection in gastroduodenal damage in patients starting NSAID therapy: 4 Months follow-up study. DigDisSci. 2010 Oct;55(10):2887-92.Sokic-Milutinovic A, Krstic M, Rozer-Smolovic B, Alempijevic T. Role of Helicobacter pylori infection in gastroduodenal damage in patients starting NSAID therapy: 4 Months follow-up study. DigDisSci. 2010 Oct;55(10):2887-92.Den Hollander W.J, Kuipers E.J. Current pharmacotherapy options for gastritis. Expert Opin Pharmacother. 2012 Dec;13(18): 2625-3.Den Hollander W.J, Kuipers E.J. Current pharmacotherapy options for gastritis. Expert Opin Pharmacother. 2012 Dec;13(18): 2625-3.Warlé-van Herwaarden MF, Koffeman AR, Valkhoff VE, ‘t Jong GW, Kramers C, Sturkenboom MC, De Smet PA. Time-trends in the prescribing of gastroprotective agents to primary care patients initiating low-dose aspirin or non-steroidal anti-inflammatory drugs: a population-based cohort study. Br J ClinPharmacol. 2015 Sep;80(3):589-98.Warlé-van Herwaarden MF, Koffeman AR, Valkhoff VE, ‘t Jong GW, Kramers C, Sturkenboom MC, De Smet PA. Time-trends in the prescribing of gastroprotective agents to primary care patients initiating low-dose aspirin or non-steroidal anti-inflammatory drugs: a population-based cohort study. Br J ClinPharmacol. 2015 Sep;80(3):589-98.Sebaldt RJ, Petrie A, Goldsmith CH, Marentette MA. Appropriateness of NSAID and Coxib prescribing for patients with osteoarthritis by primary care physicians in Ontario: results from the CANOAR study. Am J ManagCare. 2004 Nov;10(11 Pt 1):742-50.Sebaldt RJ, Petrie A, Goldsmith CH, Marentette MA. Appropriateness of NSAID and Coxib prescribing for patients with osteoarthritis by primary care physicians in Ontario: results from the CANOAR study. Am J ManagCare. 2004 Nov;10(11 Pt 1):742-50.Ray WA, Stein CM, Byrd V, Shorr R, Pichert JW, Gideon P et al; Educational program for physicians to reduce use of non-steroidal anti-inflammatory drugs among community-dwelling elderly persons: a randomized controlled trial. MedCare. 2001 May;39(5):425-35.Ray WA, Stein CM, Byrd V, Shorr R, Pichert JW, Gideon P et al; Educational program for physicians to reduce use of non-steroidal anti-inflammatory drugs among community-dwelling elderly persons: a randomized controlled trial. MedCare. 2001 May;39(5):425-35.Sung-Hun Lee, Chang-Dong Han, Ick-Hwan Yang, and Chul-Won Ha. Prescription Pattern of NSAIDs and the Prevalence of NSAID-induced Gastrointestinal Risk Factors of Orthopaedic Patients in Clinical Practice in Korea. J KoreanMedSci. 2011 Apr; 26(4): 561-567.Sung-Hun Lee, Chang-Dong Han, Ick-Hwan Yang, and Chul-Won Ha. Prescription Pattern of NSAIDs and the Prevalence of NSAID-induced Gastrointestinal Risk Factors of Orthopaedic Patients in Clinical Practice in Korea. J KoreanMedSci. 2011 Apr; 26(4): 561-567.Барановский А. Ю. Диагностика, профилактика и лечение НПВП-индуцированной колонопатии. Эксп. и клин.гастроэнтерология. 2017:146(10); стр.4-14Барановский А. Ю. Диагностика, профилактика и лечение НПВП-индуцированной колонопатии. Эксп. и клин.гастроэнтерология. 2017:146(10); стр.4-14Scarpignato C, Hunt RH. Nonsteroidal antiinflammatory drug-related injury to the gastrointestinal tract: clinical picture, pathogenesis, and prevention. GastroenterolClinNorthAm. 2010 Sep;39(3):433-64Scarpignato C, Hunt RH. Nonsteroidal antiinflammatory drug-related injury to the gastrointestinal tract: clinical picture, pathogenesis, and prevention. GastroenterolClinNorthAm. 2010 Sep;39(3):433-64LanasA, BenitoP, AlonsoJ, Hernández-CruzB, Barón-EsquiviasG, Perez-Aísa Á et al. Spanish Society of Rhematology; Spanish Association of Gastroenterology; Spanish Society of Cardiology. Safe prescription recommendations for non-steroidal anti-inflammatory drugs: consensus document ellaborated by nominated experts of three scientific associations (SER-SEC-AEG). ReumatolClin. 2014 Mar-Apr;10(2):68-84LanasA, BenitoP, AlonsoJ, Hernández-CruzB, Barón-EsquiviasG, Perez-Aísa Á et al. Spanish Society of Rhematology; Spanish Association of Gastroenterology; Spanish Society of Cardiology. Safe prescription recommendations for non-steroidal anti-inflammatory drugs: consensus document ellaborated by nominated experts of three scientific associations (SER-SEC-AEG). ReumatolClin. 2014 Mar-Apr;10(2):68-84Sostres C, Gargallo CJ, Arroyo MT, Lanas A. Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on upper gastrointestinal tract. BestPractResClinGastroenterol. 2010 Apr;24(2):121-32.Sostres C, Gargallo CJ, Arroyo MT, Lanas A. Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on upper gastrointestinal tract. BestPractResClinGastroenterol. 2010 Apr;24(2):121-32.Natalie Schellack. An overview of gastropathy induced by nonsteroidal anti-inflammatory drugs. S AfrPharm J. 2012 Vol. 79 No 4.Natalie Schellack. An overview of gastropathy induced by nonsteroidal anti-inflammatory drugs. S AfrPharm J. 2012 Vol. 79 No 4.Sugano K, Choi MG, Lin JT, Goto S, Okada Y, Kinoshita Y, Miwa H, Chiang CE, Chiba T, Hori M, Fukushima Y, Kim HS, Chang CY, Date M; LAVENDER Study Group. Multinational, double-blind, randomised, placebo-controlled, prospective study of esomeprazole in the prevention of recurrent peptic ulcer in low-dose acetylsalicylic acid users: the LAVENDER study. Gut. 2014 Jul;63(7):1061-8.Sugano K, Choi MG, Lin JT, Goto S, Okada Y, Kinoshita Y, Miwa H, Chiang CE, Chiba T, Hori M, Fukushima Y, Kim HS, Chang CY, Date M; LAVENDER Study Group. Multinational, double-blind, randomised, placebo-controlled, prospective study of esomeprazole in the prevention of recurrent peptic ulcer in low-dose acetylsalicylic acid users: the LAVENDER study. Gut. 2014 Jul;63(7):1061-8.Scheiman JM, Lanas A, Veldhuyzen van Zanten S, Baldycheva I, Svedberg LE, Nagy P. Effect of esomeprazole on gastroduodenal erosions in patients at increased gastrointestinal risk treated with low-dose acetylsalicylic acid: a post-hoc analysis of the OBERON trial. Int J Cardiol. 2015 Mar 1; 182:500-2.Scheiman JM, Lanas A, Veldhuyzen van Zanten S, Baldycheva I, Svedberg LE, Nagy P. Effect of esomeprazole on gastroduodenal erosions in patients at increased gastrointestinal risk treated with low-dose acetylsalicylic acid: a post-hoc analysis of the OBERON trial. Int J Cardiol. 2015 Mar 1; 182:500-2.Rostom A, Dube C, Wells G, et al. Prevention of NSAID-induced gastroduodenal ulcers. Cochrane Database Syst Rev 2002; 4: CD002296.Rostom A, Dube C, Wells G, et al. Prevention of NSAID-induced gastroduodenal ulcers. Cochrane Database Syst Rev 2002; 4: CD002296.Hooper L, Brown TJ, Elliott R, Payne K, Roberts C, Symmons D. The effectiveness of five strategies for the prevention of gastrointestinal toxicity induced by non-steroidal anti-inflammatory drugs: systematic review. BMJ. 2004 Oct 23;329(7472):948.Hooper L, Brown TJ, Elliott R, Payne K, Roberts C, Symmons D. The effectiveness of five strategies for the prevention of gastrointestinal toxicity induced by non-steroidal anti-inflammatory drugs: systematic review. BMJ. 2004 Oct 23;329(7472):948.Taha AS, Hudson N, Hawkey CJ, Swannell AJ, Trye PN, Cottrell J, Mann SG, Simon TJ, Sturrock RD, Russell RI: Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs. N Engl J Med. 1996, 334: 1435-1439.Taha AS, Hudson N, Hawkey CJ, Swannell AJ, Trye PN, Cottrell J, Mann SG, Simon TJ, Sturrock RD, Russell RI: Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs. N Engl J Med. 1996, 334: 1435-1439.Vaduganathan M, Bhatt D L, Cryer B L, Liu Y, Hsieh W H, Doros G, Cohen M, Lanas A, Schnitzer T J, Shook T L, Lapuerta P, Goldsmith M A, Laine L, Cannon C P; Исследователи COGENT. Proton-Pump Inhibitors Reduce Gastrointestinal Events Regardless of Aspirin Dose in Patients Requiring Dual Antiplatelet Therapy. J Am Coll Cardiol. 2016 Apr 12;67(14):1661-71.Vaduganathan M, Bhatt D L, Cryer B L, Liu Y, Hsieh W H, Doros G, Cohen M, Lanas A, Schnitzer T J, Shook T L, Lapuerta P, Goldsmith M A, Laine L, Cannon C P; Исследователи COGENT. Proton-Pump Inhibitors Reduce Gastrointestinal Events Regardless of Aspirin Dose in Patients Requiring Dual Antiplatelet Therapy. J Am Coll Cardiol. 2016 Apr 12;67(14):1661-71.GI Leontiadis, A Sreedharan, S Dorward, P Barton, B Delaney, CW Howden, et al. Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding. NIHR Health Technology Assessment programme: Executive Summaries.GI Leontiadis, A Sreedharan, S Dorward, P Barton, B Delaney, CW Howden, et al. Systematic reviews of the clinical effectiveness and cost-effectiveness of proton pump inhibitors in acute upper gastrointestinal bleeding. NIHR Health Technology Assessment programme: Executive Summaries.Mo C, Sun G, Lu M-L, et al. Proton pump inhibitors in prevention of low-dose aspirin-associated upper gastrointestinal injuries. World Journal of Gastroenterology: WJG. 2015; 21(17): 5382-5392.Mo C, Sun G, Lu M-L, et al. Proton pump inhibitors in prevention of low-dose aspirin-associated upper gastrointestinal injuries. World Journal of Gastroenterology: WJG. 2015; 21(17): 5382-5392.Scheiman JM, Behier EM, Loeffler KM, et al. Omeprazole ameliorates aspirin-induced gastroduodenal injury. Dig Dis Sci 1994; 39:97-103.Scheiman JM, Behier EM, Loeffler KM, et al. Omeprazole ameliorates aspirin-induced gastroduodenal injury. Dig Dis Sci 1994; 39:97-103.Hawkey CJ, Karrasch JA, Szczepañski L, Walker DG, Barkun A, Swannell AJ, Yeomans ND. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group. N Engl J Med. 1998 Mar 12;338(11):727-34.Hawkey CJ, Karrasch JA, Szczepañski L, Walker DG, Barkun A, Swannell AJ, Yeomans ND. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group. N Engl J Med. 1998 Mar 12;338(11):727-34.Graham DY, Agrawal NM, Campbell DR et al. Ulcer prevention in long-term users of nonsteroidal anti-in ammatory drugs: results of a double-blind, randomized, multicenter, active- and placebo-controlled study of misoprostol vs. lansoprazole. ArchIntern Med 2002; 162: 160-75.Graham DY, Agrawal NM, Campbell DR et al. Ulcer prevention in long-term users of nonsteroidal anti-in ammatory drugs: results of a double-blind, randomized, multicenter, active- and placebo-controlled study of misoprostol vs. lansoprazole. ArchIntern Med 2002; 162: 160-75.Park S.H, Cho C.S, Lee O.Y, Jun J.B, Lin S.R, Zhou L.Y, et al. Comparison of Prevention of NSAID-Induces Gastrointestinal Complications by Rebamipide and Misoprostol: A randomised, multicenter, сontrolled trial - STORM STUDY. J ClinBiochemNutr. 2007 Mar;40(2):148-55. doi: 10.3164/jcbn.40.148.Park S.H, Cho C.S, Lee O.Y, Jun J.B, Lin S.R, Zhou L.Y, et al. Comparison of Prevention of NSAID-Induces Gastrointestinal Complications by Rebamipide and Misoprostol: A randomised, multicenter, сontrolled trial - STORM STUDY. J ClinBiochemNutr. 2007 Mar;40(2):148-55. doi: 10.3164/jcbn.40.148.Л. Б. Лазебник, В. Н. Дроздов, В. А. Ким. Эффективность фамотидина в профилактике НПВП-гастропатий. Результаты Российского многоцентрового исследования ЗАСЛОН-1 (ЗАщитаСЛизистой Оболочки желудка от Нестероидных противовоспалительных препаратов), Эксп. и клин.гастроэнт., 2009, 2, 3-9Л. Б. Лазебник, В. Н. Дроздов, В. А. Ким. Эффективность фамотидина в профилактике НПВП-гастропатий. Результаты Российского многоцентрового исследования ЗАСЛОН-1 (ЗАщитаСЛизистой Оболочки желудка от Нестероидных противовоспалительных препаратов), Эксп. и клин.гастроэнт., 2009, 2, 3-9Vakil N, Fennerty M.B. Direct comparative trials of the efficacy of proton pump inhibitors in the management of gastro-oesophageal reflux disease and peptic ulcer disease. AlimentPharmacolTher. 2003 Sep 15;18(6):559-68Vakil N, Fennerty M.B. Direct comparative trials of the efficacy of proton pump inhibitors in the management of gastro-oesophageal reflux disease and peptic ulcer disease. AlimentPharmacolTher. 2003 Sep 15;18(6):559-68S. Agewall, M. Cattaneo J. P.Collet et al. Expert position paper on the use of proton pomp inhibitors in patients with cardiovascular disease and antitrombotic therapy. European Heart J., 2013, (34); 1708-1715.S. Agewall, M. Cattaneo J. P.Collet et al. Expert position paper on the use of proton pomp inhibitors in patients with cardiovascular disease and antitrombotic therapy. European Heart J., 2013, (34); 1708-1715.Qiang Niu, Zhongsu Wang, Yong Zhang, и др. Мета-анализ: комбинированное применение клопидогреля и ингибиторов протонной помпы сопровождается увеличением частоты тяжелых нежелательных сердечно-сосудистых явлений при ишемической болезни сердца, Journal of Cardiovascular Pharmacology and Therapeutics, 1-11, © TheAuthor(s) 2016, Разрешение на перепечатку: sagepub.com/journals Permissions.nav DOI: 10.1177/1074248416663647 cpt.sagepub.comQiang Niu, Zhongsu Wang, Yong Zhang, и др. Мета-анализ: комбинированное применение клопидогреля и ингибиторов протонной помпы сопровождается увеличением частоты тяжелых нежелательных сердечно-сосудистых явлений при ишемической болезни сердца, Journal of Cardiovascular Pharmacology and Therapeutics, 1-11, © TheAuthor(s) 2016, Разрешение на перепечатку: sagepub.com/journals Permissions.nav DOI: 10.1177/1074248416663647 cpt.sagepub.comHowden C.W. Review article: immediate-release proton-pump inhibitor therapy - potential advantages Aliment PharmacolTher. 2005 Dec;22Suppl 3:25-30.Howden C.W. Review article: immediate-release proton-pump inhibitor therapy - potential advantages Aliment PharmacolTher. 2005 Dec;22Suppl 3:25-30.Castell D. Review of immediate-release omeprazole for the treatment of gastric acid-related disorders. Expert OpinPharmacother. 2005 Nov;6(14):2501-10.Castell D. Review of immediate-release omeprazole for the treatment of gastric acid-related disorders. Expert OpinPharmacother. 2005 Nov;6(14):2501-10.Castell D, Bagin R, Goldlust B, Major J, Hepburn B. Comparison of the effects of immediate-release omeprazole powder for oral suspension and pantoprazole delayed-release tablets on nocturnal acid breakthrough in patients with symptomatic gastro-oesophageal reflux disease. AlimentPharmacolTher. 2005 Jun 15;21(12):1467-74.Castell D, Bagin R, Goldlust B, Major J, Hepburn B. Comparison of the effects of immediate-release omeprazole powder for oral suspension and pantoprazole delayed-release tablets on nocturnal acid breakthrough in patients with symptomatic gastro-oesophageal reflux disease. AlimentPharmacolTher. 2005 Jun 15;21(12):1467-74.Yeomans N, Wilson I, Långström G, Hawkey C, Naesdal J, Walan A, Wiklund I. Quality of life in chronic NSAID users: a comparison of the effect of omeprazole and misoprostol. Scand J Rheumatol. 2001;30(6):328-34.Yeomans N, Wilson I, Långström G, Hawkey C, Naesdal J, Walan A, Wiklund I. Quality of life in chronic NSAID users: a comparison of the effect of omeprazole and misoprostol. Scand J Rheumatol. 2001;30(6):328-34.Yeomans ND, Tulassay Z, Juhasz L et al. A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal anti-inflammatory drugs. Acid Suppression Trial: Ranitidine vs. Omeprazole for NSAIDassociated Ulcer Treatment (ASTRONAUT) Study Group. N Engl J Med 1998; 338: 719-26.Yeomans ND, Tulassay Z, Juhasz L et al. A comparison of omeprazole with ranitidine for ulcers associated with nonsteroidal anti-inflammatory drugs. Acid Suppression Trial: Ranitidine vs. Omeprazole for NSAIDassociated Ulcer Treatment (ASTRONAUT) Study Group. N Engl J Med 1998; 338: 719-26.Cullen D, Bardhan K.D, Eisner M, Kogut D.G, Peacock R.A, Thomson J.M, Hawkey C.J. Primary gastroduodenal prophylaxis with omeprazole for non-steroidal anti-inflammatory drug users. AlimentPharmacolTher. 1998 Feb;12(2):135-40.Cullen D, Bardhan K.D, Eisner M, Kogut D.G, Peacock R.A, Thomson J.M, Hawkey C.J. Primary gastroduodenal prophylaxis with omeprazole for non-steroidal anti-inflammatory drug users. AlimentPharmacolTher. 1998 Feb;12(2):135-40.Лазебник Л.Б., Ткаченко Е. И., Абдулганиева Д. И. и др. «VI Национальные рекомендации по диагностике и лечению кислотозависимых и ассоциированных с Helicobacterpylori заболеваний (VI Московские соглашения)»; Экспер. и клин.гастроэнтерология, 2017;138(2):3-19Лазебник Л.Б., Ткаченко Е. И., Абдулганиева Д. И. и др. «VI Национальные рекомендации по диагностике и лечению кислотозависимых и ассоциированных с Helicobacterpylori заболеваний (VI Московские соглашения)»; Экспер. и клин.гастроэнтерология, 2017;138(2):3-19vanSoest E.M, Valkhoff V.E, Mazzaglia G, Schade R, Molokhia M, Goldstein J.L, Hernández-DíazS, Trifirò G, Dieleman J.P, Kuipers E.J, Sturkenboom M.C. Suboptimal gastroprotective coverage of NSAID use and the risk of upper gastrointestinal bleeding and ulcers: an observational study using three European databases. Gut. 2011 Dec;60(12):1650-9.vanSoest E.M, Valkhoff V.E, Mazzaglia G, Schade R, Molokhia M, Goldstein J.L, Hernández-DíazS, Trifirò G, Dieleman J.P, Kuipers E.J, Sturkenboom M.C. Suboptimal gastroprotective coverage of NSAID use and the risk of upper gastrointestinal bleeding and ulcers: an observational study using three European databases. Gut. 2011 Dec;60(12):1650-9.Gigante A, Tagarro I. Non-steroidal anti-inflammatory drugs and gastroprotection with proton pump inhibitors: a focus on ketoprofen/omeprazole. Clin Drug Investig. 2012 Apr 1;32(4):221-33.Gigante A, Tagarro I. Non-steroidal anti-inflammatory drugs and gastroprotection with proton pump inhibitors: a focus on ketoprofen/omeprazole. Clin Drug Investig. 2012 Apr 1;32(4):221-33.Weinblatt, Michael E., Genovese, Mark C., Kivitz, Alan J., Bello, Alfonso E., Grahn, Efficacy, Safety And Tolerability Of HZT-501, Including Users Of Low-Dose Aspirin, A Single-Tablet Combination Of Ibuprofen-Famotidine: Results Of Two Phase 3 Trials. Arthritis&Rheumatism, Volume 62, November 2010 AbstractSupplement.Weinblatt, Michael E., Genovese, Mark C., Kivitz, Alan J., Bello, Alfonso E., Grahn, Efficacy, Safety And Tolerability Of HZT-501, Including Users Of Low-Dose Aspirin, A Single-Tablet Combination Of Ibuprofen-Famotidine: Results Of Two Phase 3 Trials. Arthritis&Rheumatism, Volume 62, November 2010 AbstractSupplement.Sostek M.B, Fort J.G, Estborn L, Vikman K. Long-term safety of naproxen and esomeprazole magnesium fixed-dose combination: phase III study in patients at risk for NSAID-associated gastric ulcers. CurrMedResOpin. 2011 Apr;27(4):847-54Sostek M.B, Fort J.G, Estborn L, Vikman K. Long-term safety of naproxen and esomeprazole magnesium fixed-dose combination: phase III study in patients at risk for NSAID-associated gastric ulcers. CurrMedResOpin. 2011 Apr;27(4):847-54Fujimori S, Hanada R, Hayashida M, Sakurai T, Ikushima I, Sakamoto C. Celecoxib Monotherapy Maintained Small Intestinal Mucosa Better Compared With Loxoprofen Plus Lansoprazole Treatment: A Double-blind, Randomized, Controlled Trial. J Clin Gastroenterol. 2016 Mar;50(3):218-26.Fujimori S, Hanada R, Hayashida M, Sakurai T, Ikushima I, Sakamoto C. Celecoxib Monotherapy Maintained Small Intestinal Mucosa Better Compared With Loxoprofen Plus Lansoprazole Treatment: A Double-blind, Randomized, Controlled Trial. J Clin Gastroenterol. 2016 Mar;50(3):218-26.Gwen M.C Masclee, Vera E Valkhoff 1, Eva Mvan Soest, René Schade, Giampiero Mazzaglia, Mariam Molokhia, Gianluca Trifirò et al. Cyclo-oxygenase-2 inhibitors or nonselective NSAIDs plus gastroprotective agents: what to prescribe in daily clinical practice? Aliment Pharmacol Ther. 2013 July; 38(2): 178-189.Gwen M.C Masclee, Vera E Valkhoff 1, Eva Mvan Soest, René Schade, Giampiero Mazzaglia, Mariam Molokhia, Gianluca Trifirò et al. Cyclo-oxygenase-2 inhibitors or nonselective NSAIDs plus gastroprotective agents: what to prescribe in daily clinical practice? Aliment Pharmacol Ther. 2013 July; 38(2): 178-189.B. P. M. Verhaegh, F. de Vries, A. A. M. Masclee, A. Keshavarzian, A. de Boer, P. C. Souverein, M. J. Pierik et al. High risk of drug-induced microscopic colitis with concomitant use of NSAIDs and proton pump inhibitors. Aliment PharmacolTher 2016; 43: 1004-1013.B. P. M. Verhaegh, F. de Vries, A. A. M. Masclee, A. Keshavarzian, A. de Boer, P. C. Souverein, M. J. Pierik et al. High risk of drug-induced microscopic colitis with concomitant use of NSAIDs and proton pump inhibitors. Aliment PharmacolTher 2016; 43: 1004-1013.Каратеев А.А., Насонов Е. Л., Ивашкин В. Т. и др. Клинические рекомендации «Рациональное применение нестероидных противовоспалительных препаратов (НПВП) в клинической практике»; Ассоциация ревматологов России, Российское общество по изучению боли, Российская Гастроэнтерологическая Ассоциация, Российское кардиологическое общество, Ассоциация травматологов-ортопедов России, Ассоциация междисциплинарной медицины, Российская ассоциация паллиативной медицины. М. 2015Каратеев А.А., Насонов Е. Л., Ивашкин В. Т. и др. Клинические рекомендации «Рациональное применение нестероидных противовоспалительных препаратов (НПВП) в клинической практике»; Ассоциация ревматологов России, Российское общество по изучению боли, Российская Гастроэнтерологическая Ассоциация, Российское кардиологическое общество, Ассоциация травматологов-ортопедов России, Ассоциация междисциплинарной медицины, Российская ассоциация паллиативной медицины. М. 2015Wiviott S D, Braunwald E, McCabe C H, Montalescot G, Ruzyllo W, et al, TRITON-TIMI 38 Investigators. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007;357:2001-2015.Wiviott S D, Braunwald E, McCabe C H, Montalescot G, Ruzyllo W, et al, TRITON-TIMI 38 Investigators. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007;357:2001-2015.Becker R.C, Bassand J.P, Budaj A, Wojdyla D.M, James S.K, Cornel J.H, French J, Held C, Horrow J, Husted S, Lopez-Sendon J, Lassila R, Mahaffey K.W, Storey R.F, Harrington R.A, Wallentin L. Bleeding complications with the P2Y12 receptor antagonists clopidogrel and ticagrelor in the PLATelet inhibition and patient Outcomes (PLATO) trial. Eur Heart J 2011;32:2933-2944.Becker R.C, Bassand J.P, Budaj A, Wojdyla D.M, James S.K, Cornel J.H, French J, Held C, Horrow J, Husted S, Lopez-Sendon J, Lassila R, Mahaffey K.W, Storey R.F, Harrington R.A, Wallentin L. Bleeding complications with the P2Y12 receptor antagonists clopidogrel and ticagrelor in the PLATelet inhibition and patient Outcomes (PLATO) trial. Eur Heart J 2011;32:2933-2944.Kirchhof P, Benussi S, Kotecha D, et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS European Heart Journal (2016) 37, 2893-2962.Kirchhof P, Benussi S, Kotecha D, et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS European Heart Journal (2016) 37, 2893-2962.Abraham N S, Noseworthy P A, Yao X, Sangaralingham L R, Shah N D. Gastrointestinal Safety of Direct Oral Anticoagulants: A Large Population-Based Study. Gastroenterology. 2017 Apr;152(5):1014-1022.Abraham N S, Noseworthy P A, Yao X, Sangaralingham L R, Shah N D. Gastrointestinal Safety of Direct Oral Anticoagulants: A Large Population-Based Study. Gastroenterology. 2017 Apr;152(5):1014-1022.Miller C S, Dorreen A, Martel M, Huynh T, Barkun A N. Risk of Gastrointestinal Bleeding in Patients Taking Non-Vitamin K Antagonist Oral Anticoagulants: A Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2017 Nov;15(11):1674-1683.Miller C S, Dorreen A, Martel M, Huynh T, Barkun A N. Risk of Gastrointestinal Bleeding in Patients Taking Non-Vitamin K Antagonist Oral Anticoagulants: A Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2017 Nov;15(11):1674-1683.Valgimigli M, Bueno H, Byrne R A, et al. 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS European Heart Journal (2018) 39, 213-254.Valgimigli M, Bueno H, Byrne R A, et al. 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS European Heart Journal (2018) 39, 213-254.Bhatt D L, Cryer B L, Contant C F, Cohen M, Lanas A, et al. Clopidogrel with or without omeprazole in coronary artery disease. N Engl J Med 2010;363:1909-1917.Bhatt D L, Cryer B L, Contant C F, Cohen M, Lanas A, et al. Clopidogrel with or without omeprazole in coronary artery disease. N Engl J Med 2010;363:1909-1917.Hunt R, Lazebnik L.B, Marakhouski Yu.C, Manuc M, Ramesh G.N, et al. International Consensus on Guiding Recommendations for Management of Patients with Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Induced Gastropathy - ICON-G. Euroasian Journal of Hepato-Gastroenterology. 2018; (JPJ356130218JHG) In-print.Hunt R, Lazebnik L.B, Marakhouski Yu.C, Manuc M, Ramesh G.N, et al. International Consensus on Guiding Recommendations for Management of Patients with Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Induced Gastropathy - ICON-G. Euroasian Journal of Hepato-Gastroenterology. 2018; (JPJ356130218JHG) In-print.Parambir S Dulai, Siddharth Singh, Evelyn Marquez, Rohan Khera, Larry J Prokop, Paul J Limburg, Samir Gupta, Mohammad Hassan Murad. Chemoprevention of colorectal cancer in individuals with previous colorectal neoplasia: systematic review and network meta-analysis. BMJ, 2016; i6188 DOI: 10.1136/bmj.i6188Parambir S Dulai, Siddharth Singh, Evelyn Marquez, Rohan Khera, Larry J Prokop, Paul J Limburg, Samir Gupta, Mohammad Hassan Murad. Chemoprevention of colorectal cancer in individuals with previous colorectal neoplasia: systematic review and network meta-analysis. BMJ, 2016; i6188 DOI: 10.1136/bmj.i6188Final Recommendation Statement: Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Preventive Medication. U. S. Preventive Services Task Force. September 2017. https://www.uspreventiveservicestaskforce.org/Page/Document/RecommendationStatementFinal/aspirin-to-prevent-cardiovascular-disease-and-cancerFinal Recommendation Statement: Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: Preventive Medication. U. S. Preventive Services Task Force. September 2017. https://www.uspreventiveservicestaskforce.org/Page/Document/RecommendationStatementFinal/aspirin-to-prevent-cardiovascular-disease-and-cancerЛ. И. Бурячковская, Н. В. Ломакин, А. Б. Сумароков, Е. А. Широков. Алгоритмы и шкалы риска тромбоза и кровотечения в кардиологии и неврологии. Практическое пособие. Рекомендации Национального научного общества воспаления, Российского научного медицинского общества терапевтов, Российского научного общества специалистов по рентгенэндоваскулярной диагностике и лечению. Справочное пособие для врачей общей практики, кардиологов, неврологов. М., 2018Л. И. Бурячковская, Н. В. Ломакин, А. Б. Сумароков, Е. А. Широков. Алгоритмы и шкалы риска тромбоза и кровотечения в кардиологии и неврологии. Практическое пособие. Рекомендации Национального научного общества воспаления, Российского научного медицинского общества терапевтов, Российского научного общества специалистов по рентгенэндоваскулярной диагностике и лечению. Справочное пособие для врачей общей практики, кардиологов, неврологов. М., 2018H. Decousus, V. F. Tapson, J. F. Bergmann et al. IMPROVE Investigators. Factors at admission associated with bleeding risk in medical patients: findings from the IMPROVE investigators //Chest. - 2011. - Vol.139, N1. - P. 69-79H. Decousus, V. F. Tapson, J. F. Bergmann et al. IMPROVE Investigators. Factors at admission associated with bleeding risk in medical patients: findings from the IMPROVE investigators //Chest. - 2011. - Vol.139, N1. - P. 69-79Y. Falck-Ytter, C. W. Francis, N. A. Johanson et al. Prevention of VTE in orthopedic surgery patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines, Chest. - 2012. - Vol.141, Suppl.2. - Р.e278S-e325SY. Falck-Ytter, C. W. Francis, N. A. Johanson et al. Prevention of VTE in orthopedic surgery patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines, Chest. - 2012. - Vol.141, Suppl.2. - Р.e278S-e325SM. Gould, D. A. Garcia, S. M. Wren et al. Prevention of VTE in nonorthopedic surgical patients: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines Chest. - 2012. - Vol.141, Suppl.2. - P.e227S-e277SM. Gould, D. A. Garcia, S. M. Wren et al. Prevention of VTE in nonorthopedic surgical patients: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines Chest. - 2012. - Vol.141, Suppl.2. - P.e227S-e277SПающик С. А. Профилактика внутрибольничных венозных тромбоэмболических осложнений с использованием информационных технологий. Дисс. к. м.н., М, 146 сПающик С. А. Профилактика внутрибольничных венозных тромбоэмболических осложнений с использованием информационных технологий. Дисс. к. м.н., М, 146 с

The authors declare that there are no conflicts of interest present.