nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»nogr-556Research ArticleОБЗОРREVIEWРОЛЬ АДИПОЦИТОКИНОВ, ГРЕЛИНА И ИНКРЕТИНОВ В ПРЕДИКЦИИ НЕАЛКОГОЛЬНОЙ ЖИРОВОЙ БОЛЕЗНИ ПЕЧЕНИ И ЕЕ ЛЕЧЕНИИ У ПАЦИЕНТОВ С СД 2 ТИПАROLE OF ADIPOCYTOKINES, GHRELIN AND INCRETINS IN PREDICATION OF NON-ALCOHOLIC FATTY LIVER DISEASE AND ITS TREATMENT IN PATIENTS WITH TYPE 2 DIABETESБабенкоА. Ю.BabenkoA. Yu.noemail@neicon.ruАрхиповаА. Г.ArhipovaA. G.noemail@neicon.ruБайрашеваВ. К.BayrashevaV. K.noemail@neicon.ruШляхтоЕ. В.ShlyakhtoE. V.noemail@neicon.ru«Национальный медицинский исследовательский центр им. В. А. Алмазова» Министерства Здравоохранения РоссииРоссияAlmazov National Medical Research CentreRussian Federation20182002201802121136Copyright © Бабенко А.Ю., Архипова А.Г., Байрашева В.К., Шляхто Е.В., 20182018Бабенко А.Ю., Архипова А.Г., Байрашева В.К., Шляхто Е.В.Babenko A.Y., Arhipova A.G., Bayrasheva V.K., Shlyakhto E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/556

Частота возникновения неалкогольной жировой болезни печени (НАЖБП) быстро растет во всем мире, став в настоящее время самой распространенной патологией печени. Ее объединяет с патологиями, входящими в состав метаболического синдрома (висцеральное ожирение, дислипидемия, артериальная гипертензия и нарушения углеводного обмена) общая патогенетическая основа - инсулинрезистентность. С учетом высокой распространенности НАЖБП идентификация неинвазивных предикторов ее развития и, что особенно важно, ее прогрессии с развитием фиброза до цирроза, имеет ключевое значение. Уровень гормонов жировой ткани - адипоцитокинов, напрямую связан с выраженностью инсулинрезистентности и в высокой степени детерминирует процессы воспаления и фиброзирования в печени. Соответственно, данные гормоны являются хорошими кандидатами как на роль предикторов развития и прогрессии НАЖБП, так и на роль маркеров динамического контроля метаболических эффектов терапии. Гормоны, участвующие в регуляции пищевого поведения (лептин, грелин, глюкагоно-подобный пептид 1 типа) оказывают существенные эффекты на метаболизм жировой ткани и как ее чувствительность к инсулину, так и чувствительность к инсулину ткани печени. Их динамика в процессе терапии НАЖБП также может быть важным маркером ее эффективности. Данный обзор посвящен роли адипоцитокинов и некоторых других гормонов, участвующих в регуляции чувствительности тканей к инсулину, процессов воспаления и фиброза в предикции развития, прогрессирования и ответе на терапию НАЖБП.

Incidence of non-alcoholic fatty liver disease (NAFLD) is growing rapidly throughout the world and has recently become the most common liver pathology. NAFLD's pathogenetic basis, which is insulin resistance, makes it similar to the metabolic syndrome diseases (visceral obesity, dyslipidemia, arterial hypertension and disorders of carbohydrate metabolism). High prevalence of NAFLD determines the importance of non-invasive predictors of its development and, particularly, of its progression to cirrhosis. Level of adipose tissue hormones (adipocytokines) is directly related to severity of insulin resistance and to high degree determines inflammation and fibrosis in liver. These hormones are good candidates both for predictors of NAFLD development and progression, and for markers of metabolic effects of therapy. Hormones involved in food behavior regulation (leptin, ghrelin, glucagon-like peptide type 1) have significant effects on adipose-tissue metabolism as well as adipose and liver tissue insulin sensitivity. Dynamics of these hormones in course of NAFLD treatment can also be an important marker of its effectiveness. This review explores the role of adipocytokines and other hormones in the insulin sensitivity, inflammation and fibrosis regulation in predicting development, progression and response to the therapy of NAFLD.

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The authors declare that there are no conflicts of interest present.