nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»nogr-517Research ArticleПЕРЕДОВАЯ СТАТЬЯLEADING ARTICLEРОЛЬ КИШЕЧНО-МОЗГОВОЙ ОСИ В ПАТОГЕНЕЗЕ ЗАБОЛЕВАНИЙ, АССОЦИИРОВАННЫХ С Helicobacter pyloriTHE ROLE OF INTESTINAL-BRAIN AXIS IN THE PATHOGENESIS OF DISEASES ASSOCIATED WITH Helicobacter PyloriРябиченкоЕ. В.RyabichenkoE. V.noemail@neicon.ruБургасоваО. А.BurgasovO. A.noemail@neicon.ruЖуховицкийВ. Г.ZhukhovitskiiV. G.zhukhovitsky@rambler.ruФГБУ «Федеральный научно-исследовательский центр эпидемиологии и микробиологии им. Н. Ф. Гамалеи» МЗ РФРоссияFederal research center of epidemiology and Microbiology them. N. F. GamaleiRussian FederationФГБОУ ДПО «Российская Медицинская Академия Непрерывного Профессионального Образования» МЗ РФРоссияRussian Medical Academy of Continuing Professional EducationRussian FederationФГБУ «Федеральный научно-исследовательский центр эпидемиологии и микробиологии им. Н. Ф. Гамалеи» МЗ РФ; ФГАОУ ВО «Первый МГМУ им. И. М. Сеченова» МЗ РФРоссияFederal research center of epidemiology and Microbiology them. N. F. Gamalei; First MSMU n. a. I. M. SechenovRussian Federation20172012201701248Copyright © Рябиченко Е.В., Бургасова О.А., Жуховицкий В.Г., 20172017Рябиченко Е.В., Бургасова О.А., Жуховицкий В.Г.Ryabichenko E.V., Burgasov O.A., Zhukhovitskii V.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/517

Сложное сочетание внешних факторов (стресс), иммунного статуса хозяина и факторов вирулентности определяет восприимчивость и тяжесть исхода H. pylori инфекции и связанной с ней патологии. Взаимоотношения H. pylori и «кишечно-мозговой оси» являются бинаправленными и влияют на процесс заражения и нейроэндокринную иммунологическую реакцию организма хозяина, включая изменения секреторных и моторных функций пищеварительного тракта, модификацию висцеральной чувствительности, а также когнитивных функций. Эффект H. pylori на «кишечно-мозговую ось» исходит из прямого нейротоксического действия, дефицита микроэлементов, активации воспалительных процессов в эпителии, разрушения барьерной функции, дестабилизации гематоэнцефалического барьера и системного действия провоспалительных цитокинов.

A complex combination of external factors (stress), host immune status and virulence factors determines the susceptibility and severity of the outcome of H. pneumonia infection and associated pathology. H.pylori and intestinal-brain axis relationships are bi-directional and affect the infection process and neuroendocrine immunological response of the host organism, including changes in secretory and motor functions of the digestive tract, modification of visceral sensitivity and cognitive functions. The effect of H.pylori on intestinal-brain axis is based on direct neurotoxic action, micronutrient deficiency, the activation of inflammatory processes in the epithelium, destruction of the barrier function, destabilization of the blood-brain barrier and the systemic action of pro-inflammatory cytokines.

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The authors declare that there are no conflicts of interest present.