nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»nogr-493Research ArticleПЕРЕДОВАЯ СТАТЬЯLEADING ARTICLEПЕЧЕНОЧНАЯ ЭНЦЕФАЛОПАТИЯ, СВЯЗАННАЯ С ЦИРРОЗОМ ПЕЧЕНИ. СОВРЕМЕННЫЕ ПОДХОДЫ К ПАТОГЕНЕЗУ, КЛИНИКЕ, ЛЕЧЕНИЮHEPATIC ENCEPHALOPATHY ASSOCIATED WITH CIRRHOSIS OF THE LIVER. MODERN APPROACHES TO PATHOGENESIS, CLINIC, TREATMENTПодымоваС. Д.PodymovaS. D.VKSakharov@mephi.ruМосковский клинический научно-практический центр имени А. С. ЛогиноваРоссияMoscow clinical scientific practical center named after A. S. LoginovRussian Federation201720112017011412Copyright © Подымова С.Д., 20172017Подымова С.Д.Podymova S.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/493

Важность литературных и собственных материалов, представленных в статье, заключается в значительной распространенности энцефалопатии у больных циррозом печени (она составляет 30-45 % среди больных с выраженной энцефалопатией). Минимальная энцефалопатия значительно снижает качество жизни больных циррозом печени. Не получила достаточного распространения международная классификация клинических вариантов хронической энцефалопатии. Цель проведенной работы заключается в выделении различных клинических вариантов хронической энцефалопатии и оценке новых патогенетических методов лечения, направленных на повышение эффективности терапии у больных циррозом печени.

The importance of the literature and its own materials presented in the article is the significant prevalence of encephalopathy in patients with cirrhosis of the liver (it is 30-45 % among patients with severe encephalopathy). Minimal encephalopathy significantly reduces the quality of life of patients with liver cirrhosis. The international classification of clinical variants of chronic encephalopathy has not been sufficiently extended. The goal of the work is to select various clinical variants of chronic encephalopathy and to evaluate new pathogenetic methods of treatment aimed at increasing the effectiveness of therapy in patients with cirrhosis of the liver.

энцефалопатияклассификацияклинические особенностицирроздиагнозпрогнозсхемы леченияencephalopathyclassificationclinical featurescirrhosisdiagnosisprognosistreatment regimensReferencesFerenci P, et al: Hepatic encephalopathy: definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology 2002; 35:716-721.Ferenci P, et al: Hepatic encephalopathy: definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology 2002; 35:716-721.Конн Г. О., Либертал М. М. Синдромы печеночной комы и лактулеза. - М.: Медицина, 1983. - 514 с.Конн Г. О., Либертал М. М. Синдромы печеночной комы и лактулеза. - М.: Медицина, 1983. - 514 с.Conn H. O., Bircher J. Hepatic Encephalopathy: Syndromes and Therapies//Medi-Ed Press, Bloomington. Illinois. - 1994. - 429 p.Conn H. O., Bircher J. Hepatic Encephalopathy: Syndromes and Therapies//Medi-Ed Press, Bloomington. Illinois. - 1994. - 429 p.Shawcross DL, et al: Role of ammonia and inflammation in minimal hepatic encephalopathy. Metab Brain Dis 2007; 22:125-138.Shawcross DL, et al: Role of ammonia and inflammation in minimal hepatic encephalopathy. Metab Brain Dis 2007; 22:125-138.Shawcross DL, et al: Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis. J Hepatol 2004; 40:247-254.Shawcross DL, et al: Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis. J Hepatol 2004; 40:247-254.Blei A. T., Cordoba J. The Practice Parameters Committee of the American College of Gastroenterology. Hepatic encephalopathy//Amer. J. Gastroenterol. - 2001. - Vol. 96, N 7. - P. 1968-1976.Blei A. T., Cordoba J. The Practice Parameters Committee of the American College of Gastroenterology. Hepatic encephalopathy//Amer. J. Gastroenterol. - 2001. - Vol. 96, N 7. - P. 1968-1976.Poordad FF: Review article: the burden of hepatic encephalopathy. Aliment Pharmacol Ther 2007; 25(Suppl 1):3-9.Poordad FF: Review article: the burden of hepatic encephalopathy. Aliment Pharmacol Ther 2007; 25(Suppl 1):3-9.Bustamante J, et al: Prognostic significance of hepatic encephalopathy in patients with cirrhosis. J Hepatol 1999; 30:890-895.(Ref.28)Bustamante J, et al: Prognostic significance of hepatic encephalopathy in patients with cirrhosis. J Hepatol 1999; 30:890-895.(Ref.28)Ortiz M, Jacas C, Cordoba J: Minimal hepatic encephalopathy: diagnosis, clinical significance and recommendations. J Hepatol 2005; 42(Suppl): S 45-S 53.Ortiz M, Jacas C, Cordoba J: Minimal hepatic encephalopathy: diagnosis, clinical significance and recommendations. J Hepatol 2005; 42(Suppl): S 45-S 53.Cabre E, Gassull MA: Nutrition in liver disease. Curr Opin Clin Nutr Metab Care 2005; 8:545-551.Cabre E, Gassull MA: Nutrition in liver disease. Curr Opin Clin Nutr Metab Care 2005; 8:545-551.Sharma B. C., et al: Secondary prophylaxis of hepatic encephalopathy: an open-label randomized controlled trial of lactulose versus placebo. Gastroenterology 2009; v137 p885-891.Sharma B. C., et al: Secondary prophylaxis of hepatic encephalopathy: an open-label randomized controlled trial of lactulose versus placebo. Gastroenterology 2009; v137 p885-891.Morgan MH, Read AE, Speller DC: Treatment of hepatic encephalopathy with metronidazole. Gut 1982; 23:1-7.Morgan MH, Read AE, Speller DC: Treatment of hepatic encephalopathy with metronidazole. Gut 1982; 23:1-7.Ong J.P, Gerd Oehler, Christiane Kruger-Jansen et al. L-орнитин- L -аспартат Oral L-Ornithine-L-Aspartate Improves Health-Related Quality of Life in Cirrhotic Patient with Hepatic Encephalopathy/ An Open-Label, Prospective, Multicentre Observational Study. Clin Drug Investig 2011;31(4). 213-220Ong J.P, Gerd Oehler, Christiane Kruger-Jansen et al. L-орнитин- L -аспартат Oral L-Ornithine-L-Aspartate Improves Health-Related Quality of Life in Cirrhotic Patient with Hepatic Encephalopathy/ An Open-Label, Prospective, Multicentre Observational Study. Clin Drug Investig 2011;31(4). 213-220Van der Rijt CC, et al: Overt hepatic encephalopathy precipitated by zinc deficiency. Gastroenterology 1991; 100:1114-1118.Van der Rijt CC, et al: Overt hepatic encephalopathy precipitated by zinc deficiency. Gastroenterology 1991; 100:1114-1118.Heemann U, et al: Albumin dialysis in cirrhosis with superimposed acute liver injury: a prospective, controlled study. Hepatology 2002; 36:949-958.Heemann U, et al: Albumin dialysis in cirrhosis with superimposed acute liver injury: a prospective, controlled study. Hepatology 2002; 36:949-958.Hassanein T, et al: Heat stroke: its clinical and pathological presentation, with particular attention to the liver. Am J Gastroenterol 1992; 87:1382.Hassanein T, et al: Heat stroke: its clinical and pathological presentation, with particular attention to the liver. Am J Gastroenterol 1992; 87:1382.

The authors declare that there are no conflicts of interest present.