References

nogr

Экспериментальная и клиническая гастроэнтерология

Experimental and Clinical Gastroenterology

1682-8658

«Global Media Technologies»

nogr-442

Research Article

ОБЗОР

REVIEW

ВЛИЯНИЕ SACCHAROMYCES BOULARDII НА МИКРОБИОТУ КИШЕЧНИКА. Обзор литературы

SACCHAROMYCES BOULARDII INFL UENCE OVER HUMAN MICROBIOTA. Literature review

Хавкин

А. И.

Khavkin

A. I.

gastropedklin@gmail.com

Комарова

О. Н.

Komarova

O. N.

noemail@neicon.ru

Научно-исследовательский клинический институт педиатрии имени академика Ю. Е. ВельтищеваРоссияScientific research clinical pediatrician institute by Y. VeltishevRussian Federation

2017

20062017

06126132

2017

Хавкин А.И., Комарова О.Н.

Khavkin A.I., Komarova O.N.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.nogr.org/jour/article/view/442

Saccharomyces boulardii CNCM I-745 (Saccharomyces cerevisiae HANSEN CBS 5926) - штамм дрожжей, широко применяемый в клинической практике в качестве пробиотика. Доказано его позитивное воздействие на иммунную систему, способность к связыванию патогенных микроорганизмов и блокировке образования токсинов, влияние на пищеварительные ферменты. Благодаря этим механизмам S. boulardii создают благоприятные условия для развития полезной внутрикишечной микробиоты, обеспечивают дополнительную защиту слизистой оболочки. Резервные возможности Saccharomyces boulardii заключаются в стабилизации кишечной микрофлоры у людей, которые относятся к группам риска.

Saccharomyces boulardii CNCM I-745 (Saccharomyces cerevisiae HANSEN CBS 5926) - strain of yeast, used widely in clinical evidence as probiotic. It’s positive effect of immune system, pathogenic agents adsorption and toxins blocking, influence on digestive ferments had proved. As a result S. boulardii allow for microbiota development, provides mucosa caring. Additional, Saccharomyces boulardii action brings stability to microbiota for risk groups patients.

микробиотадисбактериоз (дисбиоз)муциновый слой кишечникаслизистая оболочкакороткоцепочечные жирные кислоты (КЦЖК)пробиотик

Saccharomyces boulardii CNCM I-745Saccharomyces boulardii CNCM I-745microbiotadysbacteriosis (dysbiosis)mucin layermucous membraneshort chain fatty acids (SCFA)probiotic

References1

Бухарин О. В., Перунова Н. Б., Иванова Е. В. Бифидофлора при ассоциативном симбиозе человека. - Екатеринбург: УрО РАН, 2014. - 211 с.

Хавкин А. И. Микрофлора пищеварительного тракта. - М.: Фонд социальной педиатрии. - 2006. - 414 с.

Мор М., Свидзинский А. Saccharomyces boulardii CNCM I-745 способствуют восстановлению микробиоты кишечника после дисбактериоза на фоне диареи. Клиническая и экспериментальная гастроэнтерология, 2015, № 8, с. 237-255

Хавкин А. И., Комарова О. Н. Нарушение микробиоценоза кишечника у детей. Пособие для врачей. М: РНИМУ. - 2016. - 48 с.

Хавкин А. И., Комарова О. Н. Эффективность поликомпонентных пробиотических препаратов, включающих штаммы Lactobacillus Acidophilus LA - 14, Lactobacillus reuteri и Bifidobacterium lactis при функциональных нарушениях пищеварения у детей раннего возраста: результаты проспективного, открытого, наблюдательного исследования. Экспериментальная и клиническая гастроэнтерология, 2017, выпуск 141, № 5, с. 57-64

Бухарин О. В. Инфекционная симбиология - новое понимание старых проблем//Вестник Российской академии наук. - 2016. - Т. 86. - № 10. - С. 915-920

Kuwahara A. Contributions of colonic short-chain fatty acid receptors in energy homeostasis. Front Endocrinol. 2014; 5:144.

Abreu M. T. Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat Rev Immunol. 2010;10(2):131-144.

Kim Y. S., Ho S. B. Intestinal goblet cells and mucins in health and disease: recent insights and progress. Curr Gastroenterol Rep. 2010; 12(5): 319-330.

O’Keefe S. J., Ou J., Delany J. P. et al. Effect of fiber supplementation on the microbiota in critically ill patients. World J Gastrointest Pathophysiol. 2011; 2(6):138-145.

Voth D. E., Ballard J. D. Clostridium difficile toxins: mechanism of action and role in disease. Clin Microbiol Rev. 2005;18(2):247-263.

Kimura I., Ozawa K., Inoue D. et al. The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR 43. Nat Commun. 2013;4:1829.

MacKenzie D. A., Defernez M., Dunn W. B. et al. Relatedness of medically important strains of Saccharomyces cerevisiae as revealed by phylogenetics and metabolomics. Yeast. 2008; 25(7): 501-512.

Barc M. C., Charrin-Sarnel C., Rochet V. et al. Molecular analysis of the digestive microbiota in a gnotobiotic mouse model during antibiotic treatment: influence of Saccharomyces boulardii. Anaerobe. 2008; 14(4): 229-233.

Graff S., Chaumeil J. C., Boy P., Lai-Kuen R., Charrueau C. Influence of pH conditions on the viability of Saccharomyces boulardii yeast. J Gen Appl Microbiol. 2008; 54(4): 221-227

McFarland L. V. Use of probiotics to correct dysbiosis of normal microbiota following disease or disruptive events: a systematic review. BMJ Open. 2014; 4(8): e005047.

Kelesidis T., Pothoulakis C. Efficacy and safety of the probiotic Saccharomyces boulardii for the prevention and therapy of gastrointestinal disorders. Ther Adv Gastroenterol. 2012; 5(2): 111-125.

Barreto-Bergter E., Figueiredo R. T. Fungal glycans and the innate immune recognition. Front Cell Infect Microbiol. 2014; 4:145.

Samuelsen A. B., Schrezenmeir J., Knutsen S. H. Effects of orally administered yeast-derived β-glucans: a review. Mol Nutr Food Res. 2014; 58(1): 183-193.

Vannucci L., Krizan J., Sima P. et al. Immunostimulatory properties and antitumor activities of glucans (Review). Int J Oncol. 2013; 43(2):357-364.

Goodridge H. S., Reyes C. N., Becker C. A. et al. Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’. Nature. 2011;472(7344):471-475.

Buccigrossi V., Laudiero G., Russo C. et al. Chloride secretion induced by rotavirus is oxidative stress-dependent and inhibited by Saccharomyces boulardii in human enterocytes. PLoS One. 2014;9(6): e99830.

Oeztuerk H., Schroeder B., Beyerbach M., Breves G. Influence of living and autoclaved yeasts of Saccharomyces boulardii on in vitro ruminal microbial metabolism. J Dairy Sci. 2005; 88(7): 2594-2600.

Buts J. P., De Keyser N., Marandi S. et al. Saccharomyces boulardii upgrades cellular adaptation after proximal enterectomy in rats. Gut. 1999; 45(1): 89-96.

Czerucka D., Piche T., Rampal P. Review article: yeast as probiotics - Saccharomyces boulardii. Aliment Pharmacol Ther. 2007; 26(6): 767-778.

Buts J. P., Dekeyser N., Stilmant C., Delem E., Smets F., Sokal E. Saccharomyces boulardii produces in rat small intestine a novel protein phosphatase that inhibits Escherichia coli endotoxin by dephosphorylation. Pediatr Res. 2006; 60(1): 24-29.

Tiago F. C., Martins F. S., Souza E. L. et al. Adhesion to the yeast cell surface as a mechanism for trapping pathogenic bacteria by Saccharomyces probiotics. J Med Microbiol. 2012; 61(Pt 9): 1194-1207.

Martins F. S., Dalmasso G., Arantes R. M. et al. Interaction of Saccharomyces boulardii with Salmonella enterica serovar Typhimurium protects mice and modifies T84 cell response to the infection. PLoS One. 2010; 5(1): e8925.

Gedek B. R. Adherence of Escherichia coli serogroup O 157 and the Salmonella typhimurium mutant DT 104 to the surface of Saccharomyces boulardii. Mycoses. 1999; 42(4): 261-264.

Zbinden R., Gonczi E.-E., Altwegg M. Inhibition of Saccharomyces boulardii (nom. inval.) on cell invasion of Salmonella typhimurium and Yersinia enterocolitica. Microb Ecol Health Dis. 2011; 11(3). ISSN 1651-2235.

Ducluzeau R., Bensaada M. [Comparative effect of a single or continuous administration of “Saccharomyces boulardii” on the establishment of various strains of “candida” in the digestive tract of gnotobiotic mice]. Ann Microbiol. 1982; 133(3): 491-501. French.

Kamada N., Chen G. Y., Inohara N., Nunez G. Control of pathogens and pathobionts by the gut microbiota. Nat Immunol. 2013;14(7): 685-690.

Everard A., Matamoros S., Geurts L., Delzenne N. M., Cani P. D. Saccharomyces boulardii administration changes gut microbiota and reduces hepatic steatosis, low-grade inflammation, and fat mass in obese and type 2 diabetic db/db mice. MBio. 2014; 5(3): e01011-e01014.

Vanhoutte T., De Preter V., De Brandt E., Verbeke K., Swings J., Huys G. Molecular monitoring of the fecal microbiota of healthy human subjects during administration of lactulose and Saccharomyces boulardii. Appl Environ Microbiol. 2006; 72(9): 5990-5997.

Osowska S., Swidsinski A., Kulik Z., Lawinski M., Pertkiewicz M. Impact of saccharomyces boulardii on colonic microbiota and plasma lactate in short bowel syndrome patients on long term parenteral nutrition.Dig Dis Week. 2013; 144(5): s895.

Swidsinski A., Loening-Baucke V., Swidsinski S. Saccharomyces boulardii prevents the antibiotic induced changes in colonic microbiota. Gastroenterology. 2013; 144 (5 Suppl 1): S-824.

Chen S. J., Liu X. W., Liu J. P., Yang X. Y., Lu F. G. Ulcerative colitis as a polymicrobial infection characterized by sustained broken mucus barrier. World J Gastroenterol. 2014; 20(28): 9468-9475.

Yutin N., Galperin M. Y. A genomic update on clostridial phylogeny: Gram-negative spore formers and other misplaced clostridia. Environ Microbiol. 2013; 15(10): 2631-2641.

Vital M., Howe A. C., Tiedje J. M. Revealing the bacterial butyrate synthesis pathways by analyzing (meta)genomic data. MBio. 2014; 5(2): e00889. NCBI Taxomomy Browser. Taxomomy Browser. Available from: http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi. Accessed July 2, 2015.

Kabeerdoss J., Sankaran V., Pugazhendhi S., Ramakrishna B. S. Clostridium leptum group bacteria abundance and diversity in the fecal microbiota of patients with inflammatory bowel disease: a case-control study in India. BMC Gastroenterol. 2013;13:20.

Sokol H., Pigneur B., Watterlot L. et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A. 2008; 105(43): 16731-16736.

Qiu X., Zhang M., Yang X., Hong N., Yu C. Faecalibacterium prausnitzii upregulates regulatory T cells and anti-inflammatory cytokines in treating TNBS-induced colitis. J Crohns Colitis. 2013; 7(11): e558-e568

Swidsinski A., Loening-Baucke V., Kruger M., Kirsch S. Central nervous system and the colonic bioreactor: analysis of colonic microbiota in patients with stroke unravels unknown mechanisms of the host defense after brain injury. Intest Res. 2012; 10(4): 332-342.

Staib L., Fuchs T. M. From food to cell: nutrient exploitation strategies of enteropathogens. Microbiology. 2014; 160(Pt 6): 1020-1039.

Dubourg G., Lagier J. C., Armougom F. et al. High-level colonisation of the human gut by Verrucomicrobia following broad-spectrum antibiotic treatment. Int J Antimicrob Agents. 2013; 41(2): 149-155.

Bradlow H. L. Obesity and the gut microbiome: pathophysiological aspects. Hormone Mol Biol Clin Invest. 2014; 17(1): 53-61

The authors declare that there are no conflicts of interest present.