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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">nogr-441</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>ПРОФИЛАКТИКА ГАСТРОЭНТЕРОЛОГИЧЕСКИХ ОСЛОЖНЕНИЙ ПРИ ЛЕЧЕНИИ БОЛЬНЫХ КАРДИОЛОГИЧЕСКОГО ПРОФИЛЯ</article-title><trans-title-group xml:lang="en"><trans-title>PREVENTION OF GASTROINTESTINAL COMPLICATIONS IN THE TREATMENT OF PATIENTS WITH CARDIAC PROFILE</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Барышникова</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Baryshnikova</surname><given-names>G. A.</given-names></name></name-alternatives><email xlink:type="simple">bargalan@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чорбинская</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Chorbinskaya</surname><given-names>S. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кудрявцева</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kudryavtseva</surname><given-names>N. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central state medical Academy” of Department for presidential Affairs of RF</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>20</day><month>06</month><year>2017</year></pub-date><volume>0</volume><issue>6</issue><fpage>120</fpage><lpage>125</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Барышникова Г.А., Чорбинская С.А., Кудрявцева Н.А., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Барышникова Г.А., Чорбинская С.А., Кудрявцева Н.А.</copyright-holder><copyright-holder xml:lang="en">Baryshnikova G.A., Chorbinskaya S.A., Kudryavtseva N.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/441">https://www.nogr.org/jour/article/view/441</self-uri><abstract><p>Хорошо известно, что в структуре общей смертности в России более 57 % приходится на сердечно-сосудистые заболевания (ССЗ). С точки зрения патофизиологии в основе преждевременной сердечно-сосудистой смерти почти в половине случаев лежит атеротромбоз: ситуация, когда разрушается покрышка атеросклеротической бляшки, формируется тромб, перекрывающий частично или полностью просвет сосуда, и в зависимости от локализации поражения, у пациента развивается инфаркт миокарда, ишемический атеротромботический инсульт или гангрена нижних конечностей. Со времени завершения знаменитого фремингемского исследования появилось понятие «фактор риска» и соответственно понятие о вторичной и первичной профилактике ССЗ. К числу препаратов, которые обладают способностью снижать риск развития ССЗ, относятся антиагреганты и статины. Именно при назначении этих препаратов в ряде случаев могут возникать серьезные проблемы.</p></abstract><trans-abstract xml:lang="en"><p>It is well known that in the structure of total mortality in Russia more than 57 % are cardiovascular disease (CVD). From the point of view of pathophysiology the basis of premature cardiovascular death in almost half the cases lies with atherothrombosis: the situation when the tyre is destroyed atherosclerotic plaque is formed thrombus, covering partially or totally the lumen of the vessel, and depending on the location of the lesion, the patient develops a myocardial infarction, ischemic atherothrombotic stroke, or gangrene of the lower extremities. Since the completion of the famous Framingham study, the notion of “risk factor” and therefore the concept of secondary and primary prevention of CVD. Among the drugs that have the ability to reduce CVD risk include antiplatelet agents and statins. It was during the administration of these drugs in some cases can cause serious problems.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сердечно-сосудистые заболевания</kwd><kwd>дезагреганты</kwd><kwd>профилактика</kwd><kwd>желудочно-кишечные кровотечения</kwd><kwd>статины</kwd><kwd>неалкогольная жировая болезнь печени</kwd><kwd>трансаминазы</kwd><kwd>урсодезоксихолевая кислота</kwd><kwd>УДХК</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardiovascular disease</kwd><kwd>antiplatelet agents</kwd><kwd>prevention of gastrointestinal bleeding</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Francis K. L. et. al. Clopidogrel versus Aspirin and Esomeprazole to Prevent Recurrent Ulcer Bleeding. N Engl J Med. 2005; 352:238-44.</mixed-citation><mixed-citation xml:lang="en">Francis K. L. et. al. Clopidogrel versus Aspirin and Esomeprazole to Prevent Recurrent Ulcer Bleeding. 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