nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-240-8-13-19nogr-3409Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESВзаимосвязь витамин D-связывающего белка с неалкогольной жировой болезни печенью у больных сахарным диабетом 2 типаThe relationship of vitamin D-binding protein with non-alcoholic fatty liver disease in patients with type 2 diabetes mellitushttps://orcid.org/0000-0002-5727-1640ЯгодаА. В.YagodaA. V.noemail@neicon.ruhttps://orcid.org/0009-0007-7590-6201ДемурчеваЕ. О.DemurchevaE. O.noemail@neicon.ruhttps://orcid.org/0000-0001-6392-8461КоройП. В.KoroyP. V.noemail@neicon.ruhttps://orcid.org/0009-0006-7244-3507ДудовТ. Р.DudovT. R.timur222123@mail.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Ставропольский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияStavropol State Medical UniversityRussian FederationГосударственное бюджетное учреждение здравоохранения Ставропольского края «Краевой эндокринологический диспансер»РоссияRegional Endocrinological DispensaryRussian Federation202502082026081319Copyright © Ягода А.В., Демурчева Е.О., Корой П.В., Дудов Т.Р., 20262026Ягода А.В., Демурчева Е.О., Корой П.В., Дудов Т.Р.Yagoda A.V., Demurcheva E.O., Koroy P.V., Dudov T.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/3409

Цель исследования. Изучить взаимосвязь содержания витамин D-связывающего белка (VDBP) в крови с клинико-лабораторными проявлениями неалкогольной жировой болезни печени (НАЖБП) у пациентов с сахарным диабетом 2 типа. Материалы и методы. Обследовано 80 больных сахарным диабетом 2 типа в возрасте от 33 до 69 лет (67 женщин, 13 мужчин). НАЖБП выявлена у 75,0% пациентов с сахарным диабетом 2 типа. Выраженный стеатоз печени наблюдался в 40,0% случаях НАЖБП, фиброз F3-4 - в 23,3%. Сывороточные уровни VDBP определялись методом иммуноферментного анализа. Результаты. Наличие НАЖБП на фоне сахарного диабета 2 типа характеризовалось более низким содержанием VDBP в крови. Биохимические синдромы патологии печени, а также проявления сахарного диабета (за исключением его длительности) не влияли на сывороточные уровни VDBP при НАЖБП. У пациентов с НАЖБП и ожирением, абдоминальным ожирением или дислипидемией определялась более низкая концентрация VDBP в крови. Показатели VDBP не зависели от наличия артериальной гипертензии и метаболического синдрома при НАЖБП. У больных, имевших выраженный стеатоз или фиброз печени F3-4, регистрировалось более низкое содержание VDBP в крови. Заключение. Таким образом, при НАЖБП, ассоциированной с сахарным диабетом 2 типа, наблюдается уменьшение содержания VDBP в крови, которое связано с длительностью диабета, наличием ожирения, абдоминального ожирения и дислипидемии. Случаи НАЖБП с выраженным стеатозом или тяжелым фиброзом/циррозом печени характеризуются более низкой сывороточной концентрацией VDBP.

Aim of the investigation. To study the relationship of blood levels of vitamin D-binding protein (VDBP) with clinical and laboratory manifestations of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus. Materials and methods. The study included 80 patients with type 2 diabetes mellitus aged 33 to 69 years (67 women, 13 men). NAFLD was detected in 75.0% patients with type 2 diabetes mellitus. Severe liver steatosis was observed in 40.0% cases of NAFLD, fibrosis F3-4 in 23.3%. Serum levels of VDBP were determined by enzyme-linked immunosorbent assay. Results. The presence of NAFLD in patients with type 2 diabetes mellitus was characterized by lower blood levels of VDBP. Biochemical syndromes of liver pathology, as well as manifestations of diabetes mellitus (except for its duration) did not affect serum levels of VDBP in NAFLD. In patients with NAFLD and obesity, abdominal obesity or dyslipidemia, a lower concentration of VDBP in blood was determined. VDBP values did not depend on the presence of arterial hypertension and metabolic syndrome in NAFLD. Patients with severe liver steatosis or fibrosis F3-4 had lower blood levels of VDBP. Conclusion. Thus, in NAFLD associated with type 2 diabetes mellitus, there is a decrease of blood levels of VDBP, which is associated with the duration of diabetes, the presence of obesity, abdominal obesity and dyslipidemia. Cases of NAFLD with severe steatosis or severe fibrosis/liver cirrhosis are characterized by a lower serum concentration of VDBP.

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The authors declare that there are no conflicts of interest present.