nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-246-2-39-44nogr-3390Research ArticleКЛИНИЧЕСКАЯ ГАСТРОЭНТЕРОЛОГИЯCLINICAL GASTROENTEROLOGYКишечный микробиом у детей, рождённых от матерей с ожирениемGut microbiome in children born to women with obesityhttps://orcid.org/0000-0001-5024-1417ФирсоваЛ. А.FirsovaL. A.noemail@neicon.ruhttps://orcid.org/0000-0002-9029-2312ПанкратоваП. А.PankratovaP. A.noemail@neicon.ruhttps://orcid.org/0000-0001-9812-6899ЕвдокимоваН. В.EvdokimovaN. V.noemail@neicon.ruhttps://orcid.org/0000-0002-1116-3118БалашовА. Л.BalashovA. L.noemail@neicon.ruhttps://orcid.org/0000-0002-9532-9698ЗавьяловаА. Н.ZavyalovaA. N.noemail@neicon.ruhttps://orcid.org/0000-0002-0992-1709НовиковаВ. П.NovikovaV. P.novikova-vp@mail.ruСанкт-Петербургский государственный педиатрический медицинский университетРоссияSt. Petersburg State Pediatric Medical UniversityRussian Federation202618072026023944Copyright © Фирсова Л.А., Панкратова П.А., Евдокимова Н.В., Балашов А.Л., Завьялова А.Н., Новикова В.П., 20262026Фирсова Л.А., Панкратова П.А., Евдокимова Н.В., Балашов А.Л., Завьялова А.Н., Новикова В.П.Firsova L.A., Pankratova P.A., Evdokimova N.V., Balashov A.L., Zavyalova A.N., Novikova V.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/3390

Актуальность. Несмотря на активное изучение влияния материнского ожирения на здоровье потомства, особенности кишечной микробиоты у детей разных возрастов, рождённых от матерей с ожирением, практически не исследованы. Цель. Определить особенности кишечного микробиома у детей дошкольного и школьного возраста, рождённых от матерей с ожирением. Материалы и методы. Исследование проводилось на базе ГБУЗ «Городская поликлиника 56», ДПО 48 г. Санкт-Петербург. В исследовании приняли участие 55 детей (5-6 и 14-16 лет), которые были поделены на группы в зависимости от наличия у матери ожирения до и во время беременности (группа 1 - от матерей с ожирением, группа 2 - от матерей без ожирения). Всем детям проведена антропометрия и исследование крови на поиск микробных биомаркеров методом газовой хромато-масс-спектрометрии по методу Г.А. Осипова. Статистический анализ проводился с использованием программы StatTech v. 4.10.4. Результаты. Дети группы 1 чаще имели ожирение или избыточную массу тела (46,6% vs. 8,0%, p <0,001). В группе 1, было большее количество Actinomyces spp (р<0,001), Alcaligenes spp (р<0,001), Clostridium coccoides (р=0,035), Clostridium propionicum (р=0,002), Clostridium ramosum (р=0,004), Nocardia asteroids (р=0,002), Pseudonocardia spp (р<0,001), Ruminococcus spp (р<0,001), Staphylococcus spp (р=0,006), Streptococcus mutans (р=0,036). Уровень плазмалогена был выше в группе контроля (р=0,002), тогда как уровень суммарного эндотоксина был выше в группе 1 (р <0,001). Выводы. Дети, рождённые от матерей с ожирением, имеют особенный микробиом.

Relevance. Despite active research into the influence of maternal obesity on offspring health, the characteristics of the gut microbiota in children of various ages born to mothers with obesity have not been well studied. Objective. To determine the features of gut microbiome in preschool and school-age children born to mothers with obesity. Materials and Methods. The study was conducted at the City Polyclinic No. 56, DPO 48, St. Petersburg. It involved 55 children (aged 5-6 and 14-16 years), divided into groups based on the presence of maternal obesity before and during pregnancy (Group 1 - maternal obesity; Group 2 - controls). All children underwent anthropometric measurements and blood testing for microbial biomarkers using gas chromatography-mass spectrometry (G.A. Osipov’s method). Statistical analysis was performed using StatTech v. 4.10.4. Results. Children in Group 1 more frequently had obesity or overweight (46.6% vs. 8.0%, p<0.001). They showed higher levels of Actinomyces spp (p<0.001), Alcaligenes spp (p<0.001), Clostridium coccoides (p=0.035), Clostridium propionicum (p=0.002), Clostridium ramosum (p=0.004), Nocardia asteroids (p=0.002), Pseudonocardia spp (p<0.001), Ruminococcus spp (p<0.001), Staphylococcus spp (p=0.006), and Streptococcus mutans (p=0.036). Plasmalogen levels were higher in the control group (p=0.002), while total endotoxin levels were higher in Group 1 (p<0.001). Conclusion. Children born to mothers with obesity have a distinct gut microbiome.

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The authors declare that there are no conflicts of interest present.