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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-246-2-17-22</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-3386</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ ГАСТРОЭНТЕРОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL GASTROENTEROLOGY</subject></subj-group></article-categories><title-group><article-title>Клинико-функциональное состояние кишечника у больных псориатическим артритом</article-title><trans-title-group xml:lang="en"><trans-title>Clinical and Functional State of the Intestine in Patients with Psoriatic Arthritis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мирахмедова</surname><given-names>Х. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Mirahmedova</surname><given-names>Kh. T.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рустамова</surname><given-names>М. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Rustamova</surname><given-names>M. T.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хамраев</surname><given-names>Х. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Khamraev</surname><given-names>Kh. H.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Ташкентская медицинская академия</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Tashkent Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Самаркандский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Samarkand State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>18</day><month>07</month><year>2026</year></pub-date><volume>0</volume><issue>2</issue><fpage>17</fpage><lpage>22</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мирахмедова Х.Т., Рустамова М.Т., Хамраев Х.Х., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Мирахмедова Х.Т., Рустамова М.Т., Хамраев Х.Х.</copyright-holder><copyright-holder xml:lang="en">Mirahmedova K.T., Rustamova M.T., Khamraev K.H.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/3386">https://www.nogr.org/jour/article/view/3386</self-uri><abstract><p>Целью исследования явилось анализ клинических симптомов, эндоскопических и гистологических изменений слизистой оболочки толстой кишки у пациентов псориатическим артритом. Материал и методы. Обследовано 36 больных псориатическим артритом, из них 52,7% женщин и 47,2% мужчин, средний возраст 43,6±11,7лет. Всем больным проводилось общепринятое клиническое, лабораторное и инструментальное обследование, УЗИ, рентгенография кистей, стоп, таза. Проводилась микробиологическое исследование для выявления дисбактериоза кишечника, колоноскопия с биопсией слизистой кишечника. Результаты. По данным колоноскопии патология установлена в 66,6% случаев. В 88,8% случаев патологические изменения в кишечнике были выявлены только гистоморфологически, что свидетельствует о важности этого метода в диагностике и проведении целенаправленной адекватной терапии при поражении желудочно-кишечного тракта у больных Пс А.</p></abstract><trans-abstract xml:lang="en"><p>The aim of the study was to analyze clinical symptoms, endoscopic and histological changes in the colonic mucosa of patients with psoriatic arthritis. Materials and methods. 36 patients with psoriatic arthritis were examined, of whom 52.7% were women and 47.2% were men, with a mean age of 43.6±11.7 years. All patients underwent standard clinical, laboratory and instrumental examinations, ultrasound, and radiography of the hands, feet, and pelvis. Microbiological testing was conducted to detect intestinal dysbiosis, and colonoscopy with intestinal mucosal biopsy was performed. Results. Colonoscopy revealed pathological changes in 66.6% of cases. In 88.8% of cases, pathological changes in the intestines were detected only through histomorphological examination, which highlights the importance of this method in diagnosis and implementation of targeted appropriate therapy for gastrointestinal tract involvement in patients with psoriatic arthritis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>псориатический артрит</kwd><kwd>кишечник</kwd><kwd>колоноскопия</kwd><kwd>морфология</kwd><kwd>дисбактериоз</kwd></kwd-group><kwd-group xml:lang="en"><kwd>psoriatic arthritis</kwd><kwd>intestine</kwd><kwd>colonoscopy</kwd><kwd>morphology</kwd><kwd>dysbiosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Chia A.Y.T., Ang G.W.X., Chan A.S.Y., Chan W., Chong T.K.Y., Leung Y.Y. Managing Psoriatic Arthritis With Inflammatory Bowel Disease and/or Uveitis. 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