nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-244-12-127-134nogr-3290Research ArticleСтатьиТриметиламин- N-оксид (ТМАО) в патогенезе ревматоидного артрита и сердечно- сосудистых осложненийTrimethylamine- N-oxide (TMAO) in the pathogenesis of rheumatoid arthritis and cardiovascular complicationshttps://orcid.org/0000-0003-1496-0689ТарасоваЛ. В.TarasovaL. V.tlarisagast18@mail.ruhttps://orcid.org/0009-0006-0060-3604КокуринаК. А.KokurinaK. A.noemail@neicon.ruhttps://orcid.org/0000-0002-8339-9496ЦыгановаЮ. В.TsyganovaYu. V.noemail@neicon.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Чувашский государственный университет имени И.Н. Ульянова»РоссияChuvash State University n. a. I.N. UlyanovRussian Federation202526022026012127134Copyright © Тарасова Л.В., Кокурина К.А., Цыганова Ю.В., 20262026Тарасова Л.В., Кокурина К.А., Цыганова Ю.В.Tarasova L.V., Kokurina K.A., Tsyganova Y.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/3290

Ревматоидный артрит представляет собой многокомпонентное аутоиммунное расстройство, основными проявлениями которого служат хроническое воспаление и деструкция суставных тканей. В последние годы ключевую роль в его патогенезе отводят кишечному микробиому и его метаболитам, среди которых триметиламин-N-оксид (ТМАО) привлекает особое внимание. Кишечная микробиота- экосистема, включающая множество микроорганизмов и продукты их метаболизма, - выполняет ключевую функцию в регуляции иммунного баланса. Нарушение ее состава (дисбиоз) ассоциировано с широким спектром аутоиммунных патологий, в том числе ревматоидным артритом.

Rheumatoid arthritis is a multifactorial autoimmune disorder characterized primarily by chronic inflammation and destruction of joint tissues. In recent years, the gut microbiome and its metabolites have played a key role in its pathogenesis, among which trimethylamine N-oxide (TMAO) attracts particular attention. The gut microbiota - a complex ecosystem of many microorganisms and their metabolic products - performs a crucial function in regulating immune balance. Disruption of its composition (dysbiosis) is associated with a wide range of autoimmune diseases, including rheumatoid arthritis.

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The authors declare that there are no conflicts of interest present.