nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-244-12-88-102nogr-3284Research ArticleОБЗОРREVIEWПроблема саркопении у пациентов с воспалительными заболеваниями кишечникаThe problem of sarcopenia in patients with infl ammatory bowel disease: a reviewhttps://orcid.org/0009-0009-5739-7807АкчуринаО. Э.AkchurinaO. E.olya-akchurina@mail.ruhttps://orcid.org/0000-0003-2102-0142МухаметоваД. Д.MukhametovaD. D.noemail@neicon.ruhttps://orcid.org/0000-0001-7069-2725АбдулганиеваД. И.AbdulganievaD. I.noemail@neicon.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Казанский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияKazan State Medical UniversityRussian Federation20252602202601288102Copyright © Акчурина О.Э., Мухаметова Д.Д., Абдулганиева Д.И., 20262026Акчурина О.Э., Мухаметова Д.Д., Абдулганиева Д.И.Akchurina O.E., Mukhametova D.D., Abdulganieva D.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/3284

Цель обзора литературы: рассмотреть проблему саркопении среди пациентов с воспалительными заболеваниями кишечника (ВЗК). Основные положения. В 2019 г. EWGSOP2 выдвинули гипотезу, согласно которой развитию саркопении способствуют различные причины, среди которых и системные воспалительные заболевания, в том числе язвенный колит и болезнь Крона. В обзоре представлены актуальные гипотезы патогенеза саркопении при ВЗК с акцентом на мальнутрицию, хроническое воспаление и дисбиоз кишечника. Также были проанализированы и описаны актуальные методы диагностики саркопении применимо к пациентам с ВЗК. Отдельно рассмотрена проблема саркопенического ожирения. Особое внимание уделено влиянию генно-инженерных биологических препаратов на состояние мышечной массы. Несмотря на ограниченность данных о саркопении при ВЗК, имеющиеся исследования позволяют сделать вывод о необходимости комплексного подхода к оценке, раннему выявлению и вмешательствам, нацеленным на устранение воспалительного процесса, недостаточного питания и мышечной атрофии. Это является ключевым компонентом современных стратегий ведения пациентов с саркопенией, ассоциированной с ВЗК. Заключение. Взаимосвязь между ВЗК и саркопенией представляет собой значимую клиническую проблему, оказывающую значимое влияние на исходы лечения.

Aim: to highlight the problem of sarcopenia among patients with inflammatory bowel diseases (IBD). Key points. In 2019, EWGSOP2 hypothesized that sarcopenia is promoted by many contributing factors including inflammatory bowel diseases (ulcerative colitis and Crohn’s disease). Article presented current hypotheses of the pathogenesis of sarcopenia in patients with IBD, with an emphasis on malnutrition, chronic inflammation, and intestinal dysbiosis. Current methods for diagnosing sarcopenia in patients with IBD are presented. The problem of sarcopenic obesity is separately described. Particular attention is paid to the influence of biological agents on the state of muscles. Although data on sarcopenia in IBD are limited, the available studies suggest the need for a comprehensive approach to assessment, early detection and interventions targeted on inflammation, malnutrition, and muscle wasting. And this is a key component of comprehensive strategies for the management of IBD-associated sarcopenia. Conclusion: The interaction between IBD and sarcopenia represents a significant clinical problem with profound implications for treatment outcomes.

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The authors declare that there are no conflicts of interest present.