nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-239-7-74-87nogr-3226Research ArticleСтатьиИнфекция Helicobacter pylori: варианты внежелудочной локализации микроорганизмаHelicobacter pylori infection: variants of extragastral localizationhttps://orcid.org/0000-0001-7429-0336БарышниковаН. В.BaryshnikovaN. V.baryshnikova_nv@mail.ruhttps://orcid.org/0000-0002-2569-6660ЕрмоленкоЕ. И.ErmolenkoE. I.noemail@neicon.ruИльинаА. С.IlyinaA. S.noemail@neicon.ruhttps://orcid.org/0000-0003-2312-5589СуворовА. Н.SuvorovA. N.noemail@neicon.ruФедеральное государственное бюджетное научное учреждение «Институт Экспериментальной Медицины»; Федеральное государственное бюджетное образовательное учреждение высшего образования «Санкт-Петербургский государственный педиатрический медицинский университет» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет им. академика И.П. Павлова» Министерства здравоохранения Российской ФедерацииРоссияInstitute of Experimental Medicine; St. Petersburg State Pediatric Medical University; Pavlov First Saint Petersburg State Medical UniversityRussian FederationФедеральное государственное бюджетное научное учреждение «Институт Экспериментальной Медицины»; Федеральное государственное бюджетное образовательное учреждение высшего образования «Северо-Западный государственный медицинский университет имени И.И. Мечникова» Министерства здравоохранения Российской ФедерацииРоссияInstitute of Experimental Medicine; North-Western State Medical University named after I.I. MechnikovRussian FederationФедеральное государственное бюджетное научное учреждение «Институт Экспериментальной Медицины»; Северо-Западный окружной научно-клинический центр им. Л.Г. СоколоваРоссияInstitute of Experimental Medicine; North-Western district scientific and clinical center named after L.G. SokolovRussian FederationФедеральное государственное бюджетное научное учреждение «Институт Экспериментальной Медицины»; Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования «Санкт-Петербургский государственный университет»РоссияInstitute of Experimental Medicine; Saint Petersburg State UniversityRussian Federation202525012026077487Copyright © Барышникова Н.В., Ермоленко Е.И., Ильина А.С., Суворов А.Н., 20262026Барышникова Н.В., Ермоленко Е.И., Ильина А.С., Суворов А.Н.Baryshnikova N.V., Ermolenko E.I., Ilyina A.S., Suvorov A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/3226

Статья представляет собой комплексный обзор, систематизирующий современные данные о внежелудочных проявлениях при инфицировании Helicobacter pylori. Помимо хорошо изученной связи микроба с патологией желудочно-кишечного тракта (гастрит, язва, рак желудка), H. pylori может персистировать в других органах и оказывать системное негативное влияние на организм. В статье разбираются четыре основных пути развития внежелудочных проявлений при персистенции микроорганизма: прямая миграция бактерии и колонизация других органов, развитие хронического системного воспаления и эндотоксинемии, феномен молекулярной мимикрии, ведущий к аутоиммунным реакциям, опосредованное влияние через нарушение микробиоты кишечника (дисбиоз). Подчеркивается, что хеликобактериоз и дисбиоз кишечника являются звеньями одной патогенетической цепи. Эрадикационная терапия может усугублять дисбиоз, что указывает на потенциальную пользу применения пробиотиков.

The article presents a comprehensive review that systematizes current data on extragastric manifestations of Helicobacter pylori infection. In addition to the well-established association of the microbe with gastrointestinal pathologies (gastritis, ulcer, gastric cancer), H. pylori can persist in other organs and exert a systemic negative influence on the body. The article examines four main pathways for the development of extragastric manifestations during the persistence of the microorganism: direct migration of the bacteria and colonization of other organs, the development of chronic systemic inflammation and endotoxinemia, the phenomenon of molecular mimicry leading to autoimmune reactions, and an indirect influence through disruption of the gut microbiota (dysbiosis). It is emphasized that Helicobacter pylori infection and intestinal dysbiosis are links in the same pathogenetic chain. Eradication therapy can exacerbate dysbiosis, highlighting the potential benefit of using probiotics.

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The authors declare that there are no conflicts of interest present.