References

nogr

Экспериментальная и клиническая гастроэнтерология

Experimental and Clinical Gastroenterology

1682-8658

«Global Media Technologies»

10.31146/1682-8658-ecg-239-7-12-20

nogr-3218

Research Article

ПЕРЕДОВАЯ СТАТЬЯ

LEADING ARTICLE

Микробиота полости рта и гастроэнтерологические заболевания: гипотетическое «путешествие» пародонтальной микробиоты на «пародонтально-гастроэнтерологическом экспрессе» по маршруту рот-кишечник

Oral microbiota and gastroenterological diseases: a hypothetical “journey” of the periodontal microbiota on the “periodontal-gastroenterological express” along the route mouth-intestine

https://orcid.org/0000-0002-1597-1876

Трухан

Д. И.

Trukhan

D. I.

dmitry_trukhan@mail.ru

Федеральное государственное учреждение высшего профессионального образования «Омский государственный медицинский университет» Минздрава РоссииРоссияOmsk State Medical UniversityRussian Federation

2025

25012026

071220

2026

Трухан Д.И.

Trukhan D.I.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.nogr.org/jour/article/view/3218

Исследования и публикации последнего десятилетия кардинально меняют традиционные медицинские представления и наше понимание о возможной взаимосвязи органов и систем организма. Так, множество исследований посвящено изучению связи микробиома кишечника и различных заболеваний. Определенное влияние на микробиом кишечника оказывает микробиом полости рта. Данный обзор, основанный на опубликованных источниках из баз Pubmed и Scopus, в которых рассматривалась взаимосвязь пародонтальной микробиоты/заболеваний пародонта и гастроэнтерологических заболеваний, представляет расширенную версию доклада на круглом столе Научного общества гастроэнтерологов России 20 июня 2025 года. В рамках гипотетического «путешествия» пародонтальной микробиоты на «пародонтально-гастроэнтерологическом экспрессе» по маршруту рот-кишечник рассмотрено возможное влияние пародонтальной микробиоты и заболеваний пародонта на развитие гастроэнтерологических заболеваний. Результаты эпидемиологических, экспериментальных и клинических исследований свидетельствуют, что пародонтопатические бактерии могут принимать участие в развитии онкологических заболеваний желудочно-кишечного тракта, язвенной болезни, воспалительных заболеваний кишечника и неалкогольной жировой болезни печени.

Research and publications over the past decade have radically changed traditional medical concepts and our understanding of the possible relationship between organs and body systems. So, many studies are devoted to the study of the relationship between the intestinal microbiome and various diseases. The microbiome of the oral cavity has a certain effect on the intestinal microbiome. This review, based on published sources from the Pubmed and Scopus databases, which examined the relationship between periodontal microbiota/periodontal diseases and gastroenterological diseases, presents an expanded version of the report at the round table of the Scientific Society of Gastroenterologists of Russia on June 20, 2025. Within the framework of the hypothetical “journey” of the periodontal microbiota on the “periodontal-gastroenterological express” along the route mouth-intestine, the possible influence of the periodontal microbiota and periodontal diseases on the development of gastroenterological diseases is considered. The results of epidemiological, experimental and clinical studies indicate that periodontopathic bacteria can participate in the development of cancer of the gastrointestinal tract, peptic ulcer, inflammatory bowel disease and non-alcoholic fatty liver disease.

микробиота полости ртаболезни пародонтаось рот-кишечникрак пищеводарак желудкаколоректальный ракязвенная болезньвоспалительные заболевания кишечниканеалкогольная жировая болезнь печени

oral microbiotaperiodontal diseasesmouth-intestine axisesophageal cancerstomach cancercolorectal cancerpeptic ulcerinflammatory bowel diseasenon-alcoholic fatty liver disease

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The authors declare that there are no conflicts of interest present.