References

nogr

Экспериментальная и клиническая гастроэнтерология

Experimental and Clinical Gastroenterology

1682-8658

«Global Media Technologies»

10.31146/1682-8658-ecg-238-6-83-92

nogr-3198

Research Article

ОБЗОР

REVIEW

Тромбоэмболические осложнения у детей с воспалительными заболеваниями кишечника

Thromboembolic complications in children with inflammatory bowel disease

https://orcid.org/0009-0001-5863-1556

Алиева

Э. И.

Alieva

E. I.

el-alieva@yandex.ru

https://orcid.org/0000-0002-8514-3080

Щербакова

О. В.

Shcherbakova

O. V.

noemail@neicon.ru

https://orcid.org/0000-0002-9717-5872

Зябкин

И. В.

Zyabkin

I. V.

noemail@neicon.ru

Федеральное государственное бюджетное учреждение «Федеральный научно-клинический центр детей и подростков Федерального медико-биологического агентства России»РоссияFederal Scientific and Clinical Center for Children and Adolescents of the Federal Medical and Biological AgencyRussian Federation

2025

22012026

068392

2026

Алиева Э.И., Щербакова О.В., Зябкин И.В.

Alieva E.I., Shcherbakova O.V., Zyabkin I.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.nogr.org/jour/article/view/3198

Воспалительные заболевания кишечника (ВЗК), к которым относятся язвенный колит (ЯК) и болезнь Крона (БК), являются системным заболеванием, для них характерны внекишечные проявления и различные осложнения. Тромбоэмболические осложнения (ТЭО), включая венозные и артериальные поражения, являются редким внекишечным проявлением ВЗК и изучены недостаточно. У взрослых пациентов с ВЗК ТЭО встречается чаще в три раза, по сравнению с общей популяцией, а во время обострения заболевания их относительный риск возрастает в 15 раз. По данным литературы у детей с ВЗК ТЭО выявляется до 3% случаев. Факторами риска тромбоза являются форма ВЗК (чаще ЯК) и активность заболевания, личный и семейный анамнез тромбоза, а также традиционные факторы риска сосудистых осложнений. Церебральный венозный тромбоз (ЦВТ) - самый серьезный вид ТЭО и чаще встречается у детей. В литературе имеется множество сообщений о развитии ЦВТ на фоне ВЗК у детей, в то же время отсутствуют единые рекомендации о ведении этих пациентов. Целью исследования явилось обобщение и анализ современных данных о частоте ТЭО у детей с ВЗК.

Inflammatory bowel diseases (IBD), which include ulcerative colitis (UC) and Crohn’s disease (CD), are systemic diseases characterized by extraintestinal manifestations and various complications. Thromboembolic complications (TEC), including venous and arterial thrombosis, are rare extraintestinal manifestations of IBD and are poorly understood. In adult patients with IBD, TEC occurs three times more often than in the general population, and during an attack of the disease, their relative risk increases 15-fold. According to publications, TEC is detected in up to 3% of children with IBD. Risk factors for thrombosis include the form of IBD (usually UC) and disease activity, personal and family history of thrombosis, as well as traditional risk factors for vascular thrombosis. Cerebral venous thrombosis (CVT) is the most serious type of TEC and is more common in children. There are many reports in the literature on the development of CVT against the background of IBD in children, while there are no uniform recommendations on the management of these patients. The aim of the study was to summarize and analyze modern data on the frequency of thromboembolic complications in children with IBD.

воспалительные заболевания кишечникаязвенный колитболезнь Кронатромбоэмболические осложненияцеребральный венозный тромбозинсультдети

Inflammatory bowel diseaseUlcerative colitisCrohn’s diseaseThromboembolic complicationsCerebral venous thrombosisStrokePaediatricChildren

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The authors declare that there are no conflicts of interest present.