<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-235-3-326-333</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-3162</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Маски послеоперационного гипотиреоза</article-title><trans-title-group xml:lang="en"><trans-title>Masks of postoperative hypothyroidism</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0097-7252</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тренева</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Treneva</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">eka1006@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-4531-9682</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Косарева</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kosareva</surname><given-names>O. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0027-1786</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Булгакова</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bulgakova</surname><given-names>S. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4114-5233</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Курмаев</surname><given-names>Д. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Kurmaev</surname><given-names>D. P.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8827-4919</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шаронова</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sharonova</surname><given-names>L. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6678-6411</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Долгих</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Dolgikh</surname><given-names>Yu. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-6243-6528</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мерзлова</surname><given-names>П. Я.</given-names></name><name name-style="western" xml:lang="en"><surname>Merzlova</surname><given-names>P. Ya.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-5231-0384</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Михайлова</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Mikhailova</surname><given-names>A. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Самарский государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Samara State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>29</day><month>10</month><year>2025</year></pub-date><volume>0</volume><issue>3</issue><fpage>326</fpage><lpage>333</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Тренева Е.В., Косарева О.В., Булгакова С.В., Курмаев Д.П., Шаронова Л.А., Долгих Ю.А., Мерзлова П.Я., Михайлова А.С., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Тренева Е.В., Косарева О.В., Булгакова С.В., Курмаев Д.П., Шаронова Л.А., Долгих Ю.А., Мерзлова П.Я., Михайлова А.С.</copyright-holder><copyright-holder xml:lang="en">Treneva E.V., Kosareva O.V., Bulgakova S.V., Kurmaev D.P., Sharonova L.A., Dolgikh Y.A., Merzlova P.Y., Mikhailova A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/3162">https://www.nogr.org/jour/article/view/3162</self-uri><abstract><p>Распространенность гипотиреоза в популяции достаточно велика. Согласно данным Всемирной Организации Здравоохранения (ВОЗ), среди эндокринных заболеваний нарушения функции щитовидной железы занимают второе место, лидирует - сахарный диабет. Гипотиреоз имеет множество проявлений, поэтому врач любой специальности в своей практике имеет вероятность встретить пациента с гипотиреозом как с установленным диагнозом, так и с необходимостью проведения дифференциальной диагностики различных патологических состояний с нарушением функции щитовидной железы. В данной статье представлено клиническое наблюдение больной с длительным некомпенсированным послеоперационным гипотиреозом, ставшим причиной осложнений со стороны различных органов и систем. В клиническом наблюдении продемонстрирована эффективность заместительной терапии при лечении гипотиреоза и его осложнений. Необходимо помнить о своевременной диагностике «масок» гипотиреоза, таких как гинекологические нарушения, патология сердечно-сосудистой и гепатобилиарной систем, нарушения липидного обмена с прогрессированием атеросклероза, изменения кожи и ее придатков, ведущие к резкому снижению качества жизни пациентов. Междисциплинарный подход к ведению таких пациентов обеспечивает своевременную коррекцию осложнений, улучшение качества и продолжительности жизни пациентов.</p></abstract><trans-abstract xml:lang="en"><p>The prevalence of hypothyroidism in the population is quite high. According to the World Health Organization, thyroid dysfunction ranks second among endocrine diseases, followed by diabetes mellitus. Hypothyroidism has many manifestations, so a doctor of any specialty in his practice has a chance to meet a patient with hypothyroidism both with an established diagnosis and with the need for differential diagnostics of various pathological conditions with impaired thyroid function. This article presents a clinical observation of a patient with long-term uncompensated postoperative hypothyroidism, which caused complications in various organs and systems. The clinical observation demonstrated the effectiveness of replacement therapy in the treatment of hypothyroidism and its complications. It is necessary to remember about the timely diagnosis of “masks” of hypothyroidism, such as gynecological disorders, pathology of the cardiovascular and hepatobiliary systems, lipid metabolism disorders with the progression of atherosclerosis, changes in the skin and its appendages, leading to a sharp decrease in the quality of life of patients. An interdisciplinary approach to the management of such patients ensures timely correction of complications, improving the quality and duration of life of patients.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гипотиреоз</kwd><kwd>осложнения гипотиреоза</kwd><kwd>стеатогепатит</kwd><kwd>дислипидемия</kwd><kwd>метаболический синдром</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hypothyroidism</kwd><kwd>complications of hypothyroidism</kwd><kwd>steatohepatitis</kwd><kwd>dyslipidemia</kwd><kwd>metabolic syndrome</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Troshina E.A., Terekhova M.A. Physiological effects of thyroid hormones in the aspect of comorbidity and healthy longevity. Meditsinskiy Sovet. 2022;16(23):216-223. (In Russ.) doi: 10.21518/2079-701X-2022-16-23-216-223.@@ Трошина Е.А., Терехова М.А. Физиологические эффекты тиреоидных гормонов в аспекте коморбидности и здорового долголетия. Медицинский совет. 2022;16(23):216-223. doi: 10.21518/2079-701X-2022-16-23-216-223.</mixed-citation><mixed-citation xml:lang="en">Troshina E.A., Terekhova M.A. Physiological effects of thyroid hormones in the aspect of comorbidity and healthy longevity. Meditsinskiy Sovet. 2022;16(23):216-223. (In Russ.) doi: 10.21518/2079-701X-2022-16-23-216-223.@@ Трошина Е.А., Терехова М.А. Физиологические эффекты тиреоидных гормонов в аспекте коморбидности и здорового долголетия. Медицинский совет. 2022;16(23):216-223. doi: 10.21518/2079-701X-2022-16-23-216-223.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Fadeev V.V., Morgunova T.B., Melnichenko G.A., Dedov I.I. Draft of the clinical recommendations for diagnosis and treatment of hypothyroidism. Clinical and experimental thyroidology. 2021;17(1):4-13. (In Russ.) doi: 10.14341/ket12702.@@ Фадеев В.В., Моргунова Т.Б., Мельниченко Г.А., Дедов И.И. Проект клинических рекомендаций по гипотиреозу. Клиническая и экспериментальная тиреоидология. 2021;17(1):4-13. doi: 10.14341/ket12702.</mixed-citation><mixed-citation xml:lang="en">Fadeev V.V., Morgunova T.B., Melnichenko G.A., Dedov I.I. Draft of the clinical recommendations for diagnosis and treatment of hypothyroidism. Clinical and experimental thyroidology. 2021;17(1):4-13. (In Russ.) doi: 10.14341/ket12702.@@ Фадеев В.В., Моргунова Т.Б., Мельниченко Г.А., Дедов И.И. Проект клинических рекомендаций по гипотиреозу. Клиническая и экспериментальная тиреоидология. 2021;17(1):4-13. doi: 10.14341/ket12702.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Verbovoy A.F., Dolgikh Y.A., Kosareva O.V. et al. Insulin resistance and thyroid hormones. Pharmateca. 2017;5(338):91-95. (In Russ.) EDN: YJBRUD.@@ Вербовой А.Ф., Долгих Ю.А., Косарева О.В. и соавт. Инсулинорезистентность и тиреоидные гормоны. Фарматека. 2017;5(338):91-95. EDN: YJBRUD.</mixed-citation><mixed-citation xml:lang="en">Verbovoy A.F., Dolgikh Y.A., Kosareva O.V. et al. Insulin resistance and thyroid hormones. Pharmateca. 2017;5(338):91-95. (In Russ.) EDN: YJBRUD.@@ Вербовой А.Ф., Долгих Ю.А., Косарева О.В. и соавт. Инсулинорезистентность и тиреоидные гормоны. Фарматека. 2017;5(338):91-95. EDN: YJBRUD.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Tran H.V., Erskine N.A., Kiefe C.I., Barton B.A., Lapane K.L., Do V.T.H., Goldberg R.J. Is low iodine a risk factor for cardiovascular disease in Americans without thyroid dysfunction? Findings from NHANES. Nutr Metab Cardiovasc Dis. 2017;27(7):651-656. doi: 10.1016/j.numecd.2017.06.001.</mixed-citation><mixed-citation xml:lang="en">Tran H.V., Erskine N.A., Kiefe C.I., Barton B.A., Lapane K.L., Do V.T.H., Goldberg R.J. Is low iodine a risk factor for cardiovascular disease in Americans without thyroid dysfunction? Findings from NHANES. Nutr Metab Cardiovasc Dis. 2017;27(7):651-656. doi: 10.1016/j.numecd.2017.06.001.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Feller M., Snel M., Moutzouri E. et al. Association of Thyroid Hormone Therapy With Quality of Life and Thyroid-Related Symptoms in Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-analysis. JAMA. 2018;320(13):1349-1359. doi: 10.1001/jama.2018.13770.</mixed-citation><mixed-citation xml:lang="en">Feller M., Snel M., Moutzouri E. et al. Association of Thyroid Hormone Therapy With Quality of Life and Thyroid-Related Symptoms in Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-analysis. JAMA. 2018;320(13):1349-1359. doi: 10.1001/jama.2018.13770.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Grais I.M., Sowers J.R. Thyroid and the heart. Am J Med. 2014;127(8):691-698. doi: 10.1016/j.amjmed.2014.03.009.</mixed-citation><mixed-citation xml:lang="en">Grais I.M., Sowers J.R. Thyroid and the heart. Am J Med. 2014;127(8):691-698. doi: 10.1016/j.amjmed.2014.03.009.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bueverov A.O., Bogomolov P.O., Nechayeva O.A., Zilov A.V. Cause-and-effect relationship between thyroid and liver diseases. Meditsinskiy sovet = Medical Council. 2021;(15):88-94. (In Russ.) doi: 10.21518/2079-701X-2021-15-88-94.@@ Буеверов А.О., Богомолов П.О., Нечаева О.А., Зилов А.В. Причинно-следственная связь патологии щитовидной железы и печени. Медицинский совет. 2021;(15):88-94. doi: 10.21518/2079-701X-2021-15-88-94.</mixed-citation><mixed-citation xml:lang="en">Bueverov A.O., Bogomolov P.O., Nechayeva O.A., Zilov A.V. Cause-and-effect relationship between thyroid and liver diseases. Meditsinskiy sovet = Medical Council. 2021;(15):88-94. (In Russ.) doi: 10.21518/2079-701X-2021-15-88-94.@@ Буеверов А.О., Богомолов П.О., Нечаева О.А., Зилов А.В. Причинно-следственная связь патологии щитовидной железы и печени. Медицинский совет. 2021;(15):88-94. doi: 10.21518/2079-701X-2021-15-88-94.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Malespin M., Nassri A. Endocrine Diseases and the Liver: An Update. Clin Liver Dis. 2019;23(2):233-246. doi:10.1016/j.cld.2018.12.006.</mixed-citation><mixed-citation xml:lang="en">Malespin M., Nassri A. Endocrine Diseases and the Liver: An Update. Clin Liver Dis. 2019;23(2):233-246. doi:10.1016/j.cld.2018.12.006.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Huang M.J., Liaw Y.F. Clinical associations between thyroid and liver diseases. J Gastroenterol Hepatol. 1995;10(3):344-350. doi:10.1111/j.1440-1746.1995.tb01106.x.</mixed-citation><mixed-citation xml:lang="en">Huang M.J., Liaw Y.F. Clinical associations between thyroid and liver diseases. J Gastroenterol Hepatol. 1995;10(3):344-350. doi:10.1111/j.1440-1746.1995.tb01106.x.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Malik R., Hodgson H. The relationship between the thyroid gland and the liver. Quart J Med. 2002;95(9):559-569. doi: 10.1093/qjmed/95.9.559.</mixed-citation><mixed-citation xml:lang="en">Malik R., Hodgson H. The relationship between the thyroid gland and the liver. Quart J Med. 2002;95(9):559-569. doi: 10.1093/qjmed/95.9.559.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Handzlik-Orlik G., Krysiak R., Kędzierski L., Okopień B. Endocrine abnormalities in liver diseases. Przegl Lek. 2016;73(5):324-33. Polish. PMID: 29630140.</mixed-citation><mixed-citation xml:lang="en">Handzlik-Orlik G., Krysiak R., Kędzierski L., Okopień B. Endocrine abnormalities in liver diseases. Przegl Lek. 2016;73(5):324-33. Polish. PMID: 29630140.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Vidal-Cevallos P., Murúa-Beltrán Gall S., Uribe M., Chávez-Tapia N.C. Understanding the Relationship between Nonalcoholic Fatty Liver Disease and Thyroid Disease.Int J Mol Sci. 2023;24(19):14605. doi: 10.3390/ijms241914605.</mixed-citation><mixed-citation xml:lang="en">Vidal-Cevallos P., Murúa-Beltrán Gall S., Uribe M., Chávez-Tapia N.C. Understanding the Relationship between Nonalcoholic Fatty Liver Disease and Thyroid Disease.Int J Mol Sci. 2023;24(19):14605. doi: 10.3390/ijms241914605.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bano A., Chaker L., Plompen E.P. et al. Thyroid function and the risk of nonalcoholic fatty liver disease: the Rotterdam study. J Clin Endocrinol Metab. 2016;101(8):3204-3211. doi: 10.1210/jc.2016-1300.</mixed-citation><mixed-citation xml:lang="en">Bano A., Chaker L., Plompen E.P. et al. Thyroid function and the risk of nonalcoholic fatty liver disease: the Rotterdam study. J Clin Endocrinol Metab. 2016;101(8):3204-3211. doi: 10.1210/jc.2016-1300.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Rahadini A.A.D., Rahadina A. Association between hypothyroidism and liver fibrosis risk: a systematic review and meta-analysis. Clin Exp Hepatol. 2022;8(3):188-194. doi: 10.5114/ceh.2022.118594.</mixed-citation><mixed-citation xml:lang="en">Rahadini A.A.D., Rahadina A. Association between hypothyroidism and liver fibrosis risk: a systematic review and meta-analysis. Clin Exp Hepatol. 2022;8(3):188-194. doi: 10.5114/ceh.2022.118594.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Ritter M.J., Amano I., Hollenberg A.N. Thyroid Hormone Signaling and the Liver. Hepatology. 2020;72(2):742-752. doi: 10.1002/hep.31296.</mixed-citation><mixed-citation xml:lang="en">Ritter M.J., Amano I., Hollenberg A.N. Thyroid Hormone Signaling and the Liver. Hepatology. 2020;72(2):742-752. doi: 10.1002/hep.31296.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Sinha R.A., Bruinstroop E., Singh B.K., Yen P.M. Nonalcoholic Fatty Liver Disease and Hypercholesterolemia: Roles of Thyroid Hormones, Metabolites, and Agonists. Thyroid. 2019;29(9):1173-1191. doi: 10.1089/thy.2018.0664.</mixed-citation><mixed-citation xml:lang="en">Sinha R.A., Bruinstroop E., Singh B.K., Yen P.M. Nonalcoholic Fatty Liver Disease and Hypercholesterolemia: Roles of Thyroid Hormones, Metabolites, and Agonists. Thyroid. 2019;29(9):1173-1191. doi: 10.1089/thy.2018.0664.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Mahashabde M.L., Bhavsar H.M., Kumar L., Brugumalla S.V. A Study of Non-alcoholic Fatty Liver Disease in Patients With Hypothyroidism: A Cross-Sectional Study in a Tertiary Care Hospital. Cureus. 2024;16(9): e68956. doi: 10.7759/cureus.68956.</mixed-citation><mixed-citation xml:lang="en">Mahashabde M.L., Bhavsar H.M., Kumar L., Brugumalla S.V. A Study of Non-alcoholic Fatty Liver Disease in Patients With Hypothyroidism: A Cross-Sectional Study in a Tertiary Care Hospital. Cureus. 2024;16(9): e68956. doi: 10.7759/cureus.68956.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Bano A., Chaker L., Muka T. et al. Thyroid Function and the Risk of Fibrosis of the Liver, Heart, and Lung in Humans: A Systematic Review and Meta-Analysis. Thyroid. 2020;30(6):806-820. doi: 10.1089/thy.2019.0572.</mixed-citation><mixed-citation xml:lang="en">Bano A., Chaker L., Muka T. et al. Thyroid Function and the Risk of Fibrosis of the Liver, Heart, and Lung in Humans: A Systematic Review and Meta-Analysis. Thyroid. 2020;30(6):806-820. doi: 10.1089/thy.2019.0572.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Musso G., Gambino R., Durazzo M. et al. Adipokines in NASH: postprandial lipid metabolism as a link between adiponectin and liver disease. Hepatology. 2005;42(5):1175-1183. doi: 10.1002/hep.20896.</mixed-citation><mixed-citation xml:lang="en">Musso G., Gambino R., Durazzo M. et al. Adipokines in NASH: postprandial lipid metabolism as a link between adiponectin and liver disease. Hepatology. 2005;42(5):1175-1183. doi: 10.1002/hep.20896.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">He W., An X., Li L. et al. Relationship between hypothyroidism and non-alcoholic fatty liver disease: A systematic review and meta-analysis. Front Endocrinol. 2017;8:335. doi: 10.3389/ fendo.2017.00335.</mixed-citation><mixed-citation xml:lang="en">He W., An X., Li L. et al. Relationship between hypothyroidism and non-alcoholic fatty liver disease: A systematic review and meta-analysis. Front Endocrinol. 2017;8:335. doi: 10.3389/ fendo.2017.00335.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Mantovani A., Nascimbeni F., Lonardo A. et al. Association between primary hypothyroidism and nonalcoholic fatty liver disease: a systematic review and meta-analysis. Thyroid. 2018;28(10):1270-1284. doi: 10.1089/thy.2018.0257.</mixed-citation><mixed-citation xml:lang="en">Mantovani A., Nascimbeni F., Lonardo A. et al. Association between primary hypothyroidism and nonalcoholic fatty liver disease: a systematic review and meta-analysis. Thyroid. 2018;28(10):1270-1284. doi: 10.1089/thy.2018.0257.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Guo Z., Li M., Han B., Qi X. Association of non-alcoholic fatty liver disease with thyroid function: A systematic review and meta-analysis. Dig Liver Dis. 2018;50(11):1153-1162. doi: 10.1016/j.dld.2018.08.012.</mixed-citation><mixed-citation xml:lang="en">Guo Z., Li M., Han B., Qi X. Association of non-alcoholic fatty liver disease with thyroid function: A systematic review and meta-analysis. Dig Liver Dis. 2018;50(11):1153-1162. doi: 10.1016/j.dld.2018.08.012.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Yu H., Yang Y., Zhang M. et al. Thyroid status influence on adiponectin, acylation stimulating protein (ASP) and complement C3 in hyperthyroid and hypothyroid subjects. Nutr Metab (Lond). 2006;3:13. doi: 10.1186/1743-7075-3-13.</mixed-citation><mixed-citation xml:lang="en">Yu H., Yang Y., Zhang M. et al. Thyroid status influence on adiponectin, acylation stimulating protein (ASP) and complement C3 in hyperthyroid and hypothyroid subjects. Nutr Metab (Lond). 2006;3:13. doi: 10.1186/1743-7075-3-13.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Kim D., Kim W., Joo S.K. et al. Subclinical Hypothyroidism and Low-Normal Thyroid Function Are Associated With Nonalcoholic Steatohepatitis and Fibrosis. Clin Gastroenterol Hepatol. 2018;16(1):123-131.e1. doi: 10.1016/j.cgh.2017.08.014.</mixed-citation><mixed-citation xml:lang="en">Kim D., Kim W., Joo S.K. et al. Subclinical Hypothyroidism and Low-Normal Thyroid Function Are Associated With Nonalcoholic Steatohepatitis and Fibrosis. Clin Gastroenterol Hepatol. 2018;16(1):123-131.e1. doi: 10.1016/j.cgh.2017.08.014.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Martínez-Escudé A., Pera G., Costa-Garrido A. et al. TSH Levels as an Independent Risk Factor for NAFLD and Liver Fibrosis in the General Population. J Clin Med. 2021;10(13):2907. doi: 10.3390/jcm10132907.</mixed-citation><mixed-citation xml:lang="en">Martínez-Escudé A., Pera G., Costa-Garrido A. et al. TSH Levels as an Independent Risk Factor for NAFLD and Liver Fibrosis in the General Population. J Clin Med. 2021;10(13):2907. doi: 10.3390/jcm10132907.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Manka P., Bechmann L., Best J. et al. Low Free Triiodothyronine Is Associated with Advanced Fibrosis in Patients at High Risk for Nonalcoholic Steatohepatitis. Dig Dis Sci. 2019;64(8):2351-2358. doi: 10.1007/s10620-019-05687-3.</mixed-citation><mixed-citation xml:lang="en">Manka P., Bechmann L., Best J. et al. Low Free Triiodothyronine Is Associated with Advanced Fibrosis in Patients at High Risk for Nonalcoholic Steatohepatitis. Dig Dis Sci. 2019;64(8):2351-2358. doi: 10.1007/s10620-019-05687-3.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Liu L., Yu Y., Zhao M. et al. Benefits of Levothyroxine Replacement Therapy on Nonalcoholic Fatty Liver Disease in Subclinical Hypothyroidism Patients.Int J Endocrinol. 2017;2017:5753039. doi: 10.1155/2017/5753039.</mixed-citation><mixed-citation xml:lang="en">Liu L., Yu Y., Zhao M. et al. Benefits of Levothyroxine Replacement Therapy on Nonalcoholic Fatty Liver Disease in Subclinical Hypothyroidism Patients.Int J Endocrinol. 2017;2017:5753039. doi: 10.1155/2017/5753039.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Li L., Song Y., Shi Y., Sun L. Thyroid Hormone Receptor-β Agonists in NAFLD Therapy: Possibilities and Challenges. J Clin Endocrinol Metab. 2023;108(7):1602-1613. doi: 10.1210/clinem/dgad072.</mixed-citation><mixed-citation xml:lang="en">Li L., Song Y., Shi Y., Sun L. Thyroid Hormone Receptor-β Agonists in NAFLD Therapy: Possibilities and Challenges. J Clin Endocrinol Metab. 2023;108(7):1602-1613. doi: 10.1210/clinem/dgad072.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao M., Xie H., Shan H. et al. Development of Thyroid Hormones and Synthetic Thyromimetics in Non-Alcoholic Fatty Liver Disease.Int J Mol Sci. 2022;23(3):1102. doi: 10.3390/ijms23031102.</mixed-citation><mixed-citation xml:lang="en">Zhao M., Xie H., Shan H. et al. Development of Thyroid Hormones and Synthetic Thyromimetics in Non-Alcoholic Fatty Liver Disease.Int J Mol Sci. 2022;23(3):1102. doi: 10.3390/ijms23031102.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Ivashkin V.T., Lapina T.L., Maev I.V., Drapkina O.M., Kozlov R.S., Sheptulin A.A., et al. Clinical Practice Guidelines of Russian Gastroenterological Association, Scientific Society for the Clinical Study of Human Microbiome, Russian Society for the Prevention of Non-Communicable Diseases, Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy for Н. pylori Diagnostics and Treatment in Adults.Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2022;32(6):72-93. (In Russ.) doi: 10.22416/1382-4376-2022-32-6-72-93.@@ Ивашкин В.Т., Лапина Т.Л., Маев И.В., Драпкина О.М., Козлов Р.С., Шептулин А.А. Клинические рекомендации Российской гастроэнтерологической ассоциации, Научного сообщества по содействию клиническому изучению микробиома человека, Российского общества профилактики неинфекционных заболеваний, Межрегиональной ассоциации по клинической микробиологии и антимикробной химиотерапии по диагностике и лечению H. pylori у взрослых. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2022;32(6):72-93. doi: 10.22416/1382-4376-2022-32-6-72-93.</mixed-citation><mixed-citation xml:lang="en">Ivashkin V.T., Lapina T.L., Maev I.V., Drapkina O.M., Kozlov R.S., Sheptulin A.A., et al. Clinical Practice Guidelines of Russian Gastroenterological Association, Scientific Society for the Clinical Study of Human Microbiome, Russian Society for the Prevention of Non-Communicable Diseases, Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy for Н. pylori Diagnostics and Treatment in Adults.Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2022;32(6):72-93. (In Russ.) doi: 10.22416/1382-4376-2022-32-6-72-93.@@ Ивашкин В.Т., Лапина Т.Л., Маев И.В., Драпкина О.М., Козлов Р.С., Шептулин А.А. Клинические рекомендации Российской гастроэнтерологической ассоциации, Научного сообщества по содействию клиническому изучению микробиома человека, Российского общества профилактики неинфекционных заболеваний, Межрегиональной ассоциации по клинической микробиологии и антимикробной химиотерапии по диагностике и лечению H. pylori у взрослых. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2022;32(6):72-93. doi: 10.22416/1382-4376-2022-32-6-72-93.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Akhmedov V.A. Metabolic effects of ursodeoxycholic acid in patients with non-alcoholic fatty liver disease. Lech. Vrach. 2024;4(27):71-76. (In Russ.) doi: 10.51793/OS.2024.27.4.010.@@ Aхмедов В.А. Метаболические эффекты урсодезоксихолевой кислоты у пациентов с неалкогольной жировой болезнью печени. Лечащий Врач. 2024; 4 (27): 71-76. doi: 10.51793/OS.2024.27.4.010.</mixed-citation><mixed-citation xml:lang="en">Akhmedov V.A. Metabolic effects of ursodeoxycholic acid in patients with non-alcoholic fatty liver disease. Lech. Vrach. 2024;4(27):71-76. (In Russ.) doi: 10.51793/OS.2024.27.4.010.@@ Aхмедов В.А. Метаболические эффекты урсодезоксихолевой кислоты у пациентов с неалкогольной жировой болезнью печени. Лечащий Врач. 2024; 4 (27): 71-76. doi: 10.51793/OS.2024.27.4.010.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Ipatova M.G., Bordin D.S. The role of omega-3 polyunsaturated fatty acids in the treatment of non-alcoholic fatty liver disease: evidence base. Effective Pharmacotherapy. 2024;20 (30):44-49. (In Russ.) doi: 10.33978/2307-3586-2024-20-30-44-49.@@ Ипатова М.Г., Бордин Д.С. Роль омега-3 полиненасыщенных жирных кислот в лечении неалкогольной жировой болезни печени: доказательная база. Эффективная фармакотерапия. 2024; 20 (30): 44-49. doi: 10.33978/2307-3586-2024-20-30-44-49.</mixed-citation><mixed-citation xml:lang="en">Ipatova M.G., Bordin D.S. The role of omega-3 polyunsaturated fatty acids in the treatment of non-alcoholic fatty liver disease: evidence base. Effective Pharmacotherapy. 2024;20 (30):44-49. (In Russ.) doi: 10.33978/2307-3586-2024-20-30-44-49.@@ Ипатова М.Г., Бордин Д.С. Роль омега-3 полиненасыщенных жирных кислот в лечении неалкогольной жировой болезни печени: доказательная база. Эффективная фармакотерапия. 2024; 20 (30): 44-49. doi: 10.33978/2307-3586-2024-20-30-44-49.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
