nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-235-3-226-235nogr-3151Research ArticleМЕТАБОЛИЧЕСКИЙ СИНДРОМMETABOLIC SYNDROMEАнаболические андрогенные стероиды: оказываемый эффект и сопутствующие рискиAnabolic androgenic steroids: effects and associated riskshttps://orcid.org/0009-0004-6243-6528МерзловаП. Я.MerzlovaP. Ya.noemail@neicon.ruhttps://orcid.org/0000-0003-0027-1786БулгаковаС. В.BulgakovaS. V.osteoporosis63@gmail.comhttps://orcid.org/0000-0001-8827-4919ШароноваЛ. А.SharonovaL. A.noemail@neicon.ruhttps://orcid.org/0000-0001-6678-6411ДолгихЮ. А.DolgikhYu. A.noemail@neicon.ruhttps://orcid.org/0009-0006-4531-9682КосареваО. В.KosarevaO. V.noemail@neicon.ruhttps://orcid.org/0000-0003-0097-7252ТреневаЕ. В.TrenevaE. V.noemail@neicon.ruhttps://orcid.org/0000-0003-4114-5233КурмаевД. П.KurmaevD. P.noemail@neicon.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Самарский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияSamara State Medical UniversityRussian Federation20252910202503226235Copyright © Мерзлова П.Я., Булгакова С.В., Шаронова Л.А., Долгих Ю.А., Косарева О.В., Тренева Е.В., Курмаев Д.П., 20252025Мерзлова П.Я., Булгакова С.В., Шаронова Л.А., Долгих Ю.А., Косарева О.В., Тренева Е.В., Курмаев Д.П.Merzlova P.Y., Bulgakova S.V., Sharonova L.A., Dolgikh Y.A., Kosareva O.V., Treneva E.V., Kurmaev D.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/3151

Анаболические андрогенные стероиды (ААС) являются фармакологическими препаратами, производными тестостерона, обладающими сходным с ним строением и механизмами действия. Заместительная терапия препаратами тестостерона - ведущий метод лечения стойкого мужского гипогонадизма различной этиологии, однако, в связи с анаболическим эффектом ААС, оказываемым на скелетную мышечную ткань, в настоящее время данный класс препаратов широко используется спортсменами и атлетами без должного контроля и наблюдения специалистами. Такое употребление ААС сопровождается серьезными побочными эффектами, которые не всегда обратимы даже после отмены производных тестостерона. В обзоре представлены статистические данные распространенности приема ААС, описаны механизмы анаболического действия на скелетную мускулатуру, а также побочные эффекты. Возможные негативные последствия приема супрафизиологических доз ААС включают подавление функции оси гипоталамус-гипофиз-гонады, повышение сердечно-сосудистых рисков, гепатотоксичность, структурные и функциональные нарушения нервной системы. Целью данного обзора авторы ставят повышение осведомленности о влиянии на организм ААС, что позволит предупредить и минимизировать риски, сопряженные с бесконтрольным употреблением данного класса препаратов.

Anabolic androgenic steroids (AAS) are pharmacological agents, testosterone derivatives, with a similar structure and mechanisms of action. Replacement therapy with testosterone is the leading method of treating persistent male hypogonadism of various etiologies; however, due to the anabolic effect of AAS on skeletal muscle tissue, this class of drugs is currently widely used by athletes without proper control and supervision by specialists. Such use of AAS is accompanied by serious side effects, which are not always reversible even after discontinuation of testosterone derivatives. The review presents statistical data on the prevalence of AAS use, describes the mechanisms of anabolic action on skeletal muscles, as well as side effects. Possible negative effects of taking large doses of AAS include suppression of the hypothalamic-pituitary-gonadal axis, increased cardiovascular risks, hepatotoxicity, structural and functional disorders of the nervous system. The aim of this review is to raise awareness of the effects of AAS on the body, which will help prevent and minimize the risks associated with the uncontrolled use of this class of drugs.

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The authors declare that there are no conflicts of interest present.