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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-235-3-168-176</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-3144</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕТАБОЛИЧЕСКИЙ СИНДРОМ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>METABOLIC SYNDROME</subject></subj-group></article-categories><title-group><article-title>Нервная анорексия как причина эндокринных нарушений</article-title><trans-title-group xml:lang="en"><trans-title>Anorexia nervosa as a cause of endocrine disorders</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-6243-6528</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мерзлова</surname><given-names>П. Я.</given-names></name><name name-style="western" xml:lang="en"><surname>Merzlova</surname><given-names>P. Ya.</given-names></name></name-alternatives><email xlink:type="simple">p.ya.merzlova@samsmu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0027-1786</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Булгакова</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bulgakova</surname><given-names>S. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6678-6411</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Долгих</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Dolgikh</surname><given-names>Yu. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8827-4919</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шаронова</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sharonova</surname><given-names>L. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-4531-9682</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Косарева</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kosareva</surname><given-names>O. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Самарский государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Samara State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>29</day><month>10</month><year>2025</year></pub-date><volume>0</volume><issue>3</issue><fpage>168</fpage><lpage>176</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мерзлова П.Я., Булгакова С.В., Долгих Ю.А., Шаронова Л.А., Косарева О.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Мерзлова П.Я., Булгакова С.В., Долгих Ю.А., Шаронова Л.А., Косарева О.В.</copyright-holder><copyright-holder xml:lang="en">Merzlova P.Y., Bulgakova S.V., Dolgikh Y.A., Sharonova L.A., Kosareva O.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/3144">https://www.nogr.org/jour/article/view/3144</self-uri><abstract><p>Безусловно, в настоящее время ожирение является глобальной проблемой здравоохранения. Заметно реже обсуждаются расстройства пищевого поведения, включающие нервную анорексию - патологию нервно-психической сферы, характеризующуюся сознательным отказом от приема пищи и выраженным снижением массы тела. Высокая вероятность летального исхода при нервной анорексии обусловлена широким спектром ее осложнений, прежде всего, со стороны половой и эндокринной систем. Наиболее распространенными неблагоприятными последствиями нервной анорексии являются гипогонадотропный гипогонадизм и аменорея, нарушение действия гормона роста, гиперкортицизм, снижение минеральной плотности костной ткани и риск переломов. Перечисленные осложнения не всегда разрешаются самостоятельно даже после возобновления рационального питания и нормализации массы тела. Более того, наибольшая распространенность нервной анорексии отмечается среди лиц женского пола в подростковом возрасте, то есть, в периоде активного линейного роста, достижения пиковой костной массы и полового созревания. Осведомленность о патофизиологии и клинических проявлениях сопутствующих нервной анорексии эндокринных нарушений может помочь при обследовании пациентов и выборе дальнейшей терапевтической стратегии, тем более что в настоящее время все еще не разработан единый протокол лечения нервной анорексии.</p></abstract><trans-abstract xml:lang="en"><p>Obviously, obesity is currently a global health problem. Eating disorders, including anorexia nervosa, a neuropsychiatric disorder characterized by a conscious refusal to eat and a significant decrease in body weight, are discussed much less frequently. The high probability of a fatal outcome in anorexia nervosa is due to a wide range of its complications, primarily in the reproductive and endocrine systems. The most common adverse effects of anorexia nervosa are hypogonadotropic hypogonadism and amenorrhea, impaired growth hormone action, hypercorticism, decreased bone mineral density, and the risk of fractures. These complications do not always resolve on their own even after the resumption of rational nutrition and normalization of body weight. Moreover, anorexia nervosa is most common among females in adolescence, that is, during the period of active linear growth, reaching peak bone mass, and puberty. Awareness of the pathophysiology and clinical manifestations of endocrine disorders associated with anorexia nervosa can help in examining patients and choosing a further therapeutic strategy, especially since a unified protocol for the treatment of anorexia nervosa has not yet been developed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>нервная анорексия</kwd><kwd>дефицит массы тела</kwd><kwd>лептин</kwd><kwd>грелин</kwd><kwd>функциональная гипоталамическая аменорея</kwd><kwd>гипогонадотропный гипогонадизм</kwd><kwd>метаболизм костной ткани</kwd></kwd-group><kwd-group xml:lang="en"><kwd>anorexia nervosa</kwd><kwd>body weight deficit</kwd><kwd>leptin</kwd><kwd>ghrelin</kwd><kwd>functional hypothalamic amenorrhea</kwd><kwd>hypogonadotropic hypogonadism</kwd><kwd>bone metabolism</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Zakharova L.I. 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