References

nogr

Экспериментальная и клиническая гастроэнтерология

Experimental and Clinical Gastroenterology

1682-8658

«Global Media Technologies»

10.31146/1682-8658-ecg-234-2-52-61

nogr-3068

Research Article

КЛИНИЧЕСКАЯ ГАСТРОЭНТЕРОЛОГИЯ

CLINICAL GASTROENTEROLOGY

Клинические особенности течения COVID-19 у госпитализированных пациентов с неалкогольной жировой болезнью печени

Clinical features of COVID-19 in hospitalized patients with non-alcoholic fatty liver disease

https://orcid.org/0000-0001-5098-9206

Алиева

С. А.

Alieva

S. A.

asu0507@mail.ru

https://orcid.org/0000-0003-1699-0881

Никитин

И. Г.

Nikitin

I. G.

noemail@neicon.ru

https://orcid.org/0000-0001-6986-901X

Васильева

И. В.

Vasilyeva

I. V.

noemail@neicon.ru

Медицинский университет Семей; Федеральное государственное автономное образовательное учреждение высшего образования Российский национальный исследовательский медицинский университет имени Н.И. Пирогова Минздрава РоссииРоссияSemey Medical University; N. I. Pirogov Russian National Research Medical UniversityRussian Federation

Федеральное государственное автономное образовательное учреждение высшего образования Российский национальный исследовательский медицинский университет имени Н.И. Пирогова Минздрава РоссииРоссияN. I. Pirogov Russian National Research Medical UniversityRussian Federation

2025

31082025

025261

2025

Алиева С.А., Никитин И.Г., Васильева И.В.

Alieva S.A., Nikitin I.G., Vasilyeva I.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.nogr.org/jour/article/view/3068

Пандемия СOVID-19 явилась серьезным испытанием для многих коморбидных пациентов, в том числе и с патологией гепатобилиарного тракта. Факторами риска тяжелого течения СOVID-19 инфекции были пожилой возраст, мужской пол, наличие сопутствующих заболеваний. Цель исследования: Выявить факторы риска тяжелого течения COVID-19 у госпитализированных пациентов с НАЖБП. Материалы и методы: Проведен ретроспективный и проспективный анализ 185 историй болезней пациентов, госпитализированных с СOVID-19 в инфекционные стационары г. Москвы в период с июня по август 2021года. Результаты исследования: Пациенты с НАЖБП, госпитализированные с СOVID-19 в сравнении с группой сравнения были старшего возраста, имели более высокий индекс коморбидности, высокий индекс массы тела (ИМТ) и более длительную госпитализацию. Анализ лабораторных показателей АЛТ, АСТ, СРБ, ГГТП в динамике выявил статистически достоверную связь показателей цитолиза, воспаления с необходимостью в неотложной респираторной поддержке (ИВЛ). Вывод: Факторами риска тяжелого течения COVID-19 госпитализированных пациентов с НАЖБП являются старший возраст, мужской пол, повышенный вес, высокие показатели цитолиза и воспаления при поступлении и превышение их на 7 день госпитализации, что требует дополнительных мер неотложной терапии, респираторной поддержки и следовательно более длительной госпитализации.

The COVID-19 pandemic has been a serious challenge for many comorbid patients, including those with pathology of the hepatobiliary tract. Risk factors for severe COVID-19 infection were older age, male gender, and the presence of concomitant diseases. Purpose of the study: To identify risk factors for severe COVID-19 in hospitalized patients with NAFLD. Materials and methods: A retrospective and prospective analysis of 185 medical records of patients hospitalized with COVID-19 in infectious diseases hospitals in Moscow from June to August 2021 was carried out. Study results: Patients with NAFLD hospitalized with COVID-19 compared to the comparison group were older, had a higher comorbidity index, a high body mass index (BMI) and longer hospitalization. Analysis of laboratory parameters of ALT, AST, CRP, GGTP over time revealed a statistically significant connection between the parameters of cytolysis and inflammation and the need for emergency respiratory support (ventilation). Conclusion: Risk factors for severe COVID-19 in hospitalized patients with NAFLD are older age, male gender, increased weight, high rates of cytolysis and inflammation upon admission and exceeding them on the 7th day of hospitalization, which requires additional measures of emergency therapy, respiratory support and, consequently, longer hospitalization.

факторы рискатяжесть теченияСOVID-19НАЖБПИВЛ

risk factorsseverity of the courseCOVID-19NAFLDmechanical ventilation

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The authors declare that there are no conflicts of interest present.