<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-237-5-10-17</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-3029</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ХИРУРГИЧЕСКАЯ ГАСТРОЭНТЕРОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SURGICAL GASTROENTEROLOGY</subject></subj-group></article-categories><title-group><article-title>Инфильтративный рак пищевода: трудности эндоскопической дифференциальной диагностики</article-title><trans-title-group xml:lang="en"><trans-title>Infiltrative esophageal cancer: difficulties of endoscopic differential diagnosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1920-3257</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Булганина</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bulganina</surname><given-names>N. A.</given-names></name></name-alternatives><email xlink:type="simple">kuzma73@ya.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5320-788X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Годжелло</surname><given-names>Э. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Godzhello</surname><given-names>E. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9906-5255</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хрусталева</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Khrustaleva</surname><given-names>M. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5510-9140</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белисова</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Belisova</surname><given-names>T. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное научное учреждение «Российский научный центр хирургии имени академика Б.В. Петровского»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Petrovsky National Research Center of Surgery</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>18</day><month>07</month><year>2025</year></pub-date><volume>0</volume><issue>5</issue><fpage>10</fpage><lpage>17</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Булганина Н.А., Годжелло Э.А., Хрусталева М.В., Белисова Т.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Булганина Н.А., Годжелло Э.А., Хрусталева М.В., Белисова Т.В.</copyright-holder><copyright-holder xml:lang="en">Bulganina N.A., Godzhello E.A., Khrustaleva M.V., Belisova T.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/3029">https://www.nogr.org/jour/article/view/3029</self-uri><abstract><p>Введение. Диффузный инфильтративный рака пищевода встречается крайне редко, публикации ограничиваются описанием отдельных клинических наблюдений. Дифференциальная диагностика и морфологическая верификация чрезвычайно трудна, что отдаляет установление точного диагноза. Такой тип роста опухоли может быть как первичным, так и вторичным, например, при метастазировании рака молочной железы. Цель. Рассмотреть различные варианты эндоскопической семиотики диффузного инфильтративного рака пищевода и проанализировать трудности дифференциальной диагностики с другими патологическими состояниями пищевода на основании собственного опыта. Материалы и методы. С 2013 по 2024 гг. у 10 пациентов с жалобами на дисфагию при эндоскопическом исследовании возникло подозрение на инфильтративное бластоматозное поражение. С целью эндоскопической дифференциальной диагностики рассмотрена группа из 14 пациентов с доброкачественными стенозирующими заболеваниями пищевода. Результаты. По совокупности результатов эндоскопических, лучевых и морфологических методов обследования семи пациентам из десяти была рекомендована консультация хирургов и онкологов. У трех пациентов были установлены саморасправляющиеся эндопротезы. Из 14 пациентов с доброкачественными сужениями пищевода один оперирован - выполнена энуклеация, верифицирован фибромиоматоз. У остальных выполняли бужирование или баллонную дилатацию в комбинации с антисекреторной, антацидной и мукопротекторной терапией с хорошими результатами. В сложных случаях высокая эффективность эндоскопических методов лечения свидетельствует о доброкачественном характере заболевания. Однако нельзя терять бдительность и не следует забывать о возможности прогрессирования процесса и малигнизации при длительной альтерации тканей. Заключение. Инфильтративный рак пищевода встречается редко и его трудно диагностировать. Прогрессирование заболевания и его инвазивность обусловливают неблагоприятный прогноз. Для уменьшения процента запоздалой диагностики и улучшения результатов лечения требуется пристальное внимание ко всем пациентам с дисфагией и своевременное направление их в экспертные учреждения.</p></abstract><trans-abstract xml:lang="en"><p>Introduction. Diffusely infiltrative esophageal cancer is extremely rare; publications are limited to descriptions of sporadic clinical observations. Differential diagnosis and morphological verification are extremely difficult, which lead to accurate diagnosis delays. This type of tumor growth can be both primary and secondary, for example, with metastasis of breast cancer. Aim. To consider various endoscopic semiotics of diffuse infiltrative esophageal cancer and analyze the difficulties of differential diagnosis with other pathological conditions of the esophagus based on our own experience. Materials and methods. From 2013 to 2024 endoscopic examination suggested suspicion of infiltrative malignant lesion in 10 patients with complaints of dysphagia. A group of 14 patients with benign stenotic diseases of the esophagus was examined for the purpose of endoscopic differential diagnostics. Results. Based on the results of endoscopic, radiation and morphological diagnostic methods, 7 out of 10 patients were recommended to consult surgeons and oncologists. Self-expanding endoprostheses were installed in 3 patients. 1 of the 14 patients with benign stenosis of the esophagus was operated - enucleation with verified fibromyomatosis. The rest underwent bougienage or balloon dilation in combination with antisecretory, antacid and mucoprotective therapy with good results. In complex cases, the high efficiency of endoscopic treatment methods indicates the benign nature of the disease. However, it is extremely important not to lose vigilance and not to forget about the possibility of progression and malignancy with long-term tissue alteration. Conclusion. Infiltrative esophageal cancer is rare and difficult to diagnose. Disease progression and invasiveness determine an unfavorable prognosis. In order to reduce the percentage of late diagnosis and improve treatment results, close attention to all patients with dysphagia and their timely referral to expert institutions is required.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рак пищевода</kwd><kwd>инфильтративный рак</kwd><kwd>скирр</kwd><kwd>linitis plastica</kwd><kwd>эндоскопическая дифференциальная диагностика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>esophageal cancer</kwd><kwd>infiltrative cancer</kwd><kwd>scirrhus</kwd><kwd>linitis plastica</kwd><kwd>endoscopic differential diagnosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Natsugoe S., Matsushita Y., Kijima F. et al. Diffusely infiltrative squamous cell carcinoma of the esophagus. Surg Today. 1998; 28 (2): 129-34. doi: 10.1007/s005950050093.</mixed-citation><mixed-citation xml:lang="en">Natsugoe S., Matsushita Y., Kijima F. et al. Diffusely infiltrative squamous cell carcinoma of the esophagus. Surg Today. 1998; 28 (2): 129-34. doi: 10.1007/s005950050093.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Usui A., Akutsu Y., Kano M. et al. Diffusely infiltrative squamous cell carcinoma of the esophagus presenting as a case with diagnostic difficulty. Surg Today. 2013 Jul; 43 (7): 794-9. doi: 10.1007/s00595-012-0400-9.</mixed-citation><mixed-citation xml:lang="en">Usui A., Akutsu Y., Kano M. et al. Diffusely infiltrative squamous cell carcinoma of the esophagus presenting as a case with diagnostic difficulty. Surg Today. 2013 Jul; 43 (7): 794-9. doi: 10.1007/s00595-012-0400-9.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Kawaguchi H., Kuwano H., Araki K. et al. Esophageal carcinoma showing a long stricture due to prominent lymphatic permeation: report of a case. Surg Today. 1999; 29:545-8.</mixed-citation><mixed-citation xml:lang="en">Kawaguchi H., Kuwano H., Araki K. et al. Esophageal carcinoma showing a long stricture due to prominent lymphatic permeation: report of a case. Surg Today. 1999; 29:545-8.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">El-Nakeep S., Kasi A. Linitis Plastica. 2023 Aug 13. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. PMID: 33085441.</mixed-citation><mixed-citation xml:lang="en">El-Nakeep S., Kasi A. Linitis Plastica. 2023 Aug 13. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. PMID: 33085441.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Marín-López C.A., Maltez A.S. Pseudoachalasia and linitis plastica. Rev Gastroenterol Mex (Engl Ed). 2023 Jul-Sep; 88(3): 284-286. doi: 10.1016/j.rgmxen.2023.05.005.</mixed-citation><mixed-citation xml:lang="en">Marín-López C.A., Maltez A.S. Pseudoachalasia and linitis plastica. Rev Gastroenterol Mex (Engl Ed). 2023 Jul-Sep; 88(3): 284-286. doi: 10.1016/j.rgmxen.2023.05.005.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Pazdur R., Olencki T., Herman G.E. Linitis plastica of the esophagus. Am J Gastroenterol. 1988 Dec;83(12):1395-7. PMID: 2848410.</mixed-citation><mixed-citation xml:lang="en">Pazdur R., Olencki T., Herman G.E. Linitis plastica of the esophagus. Am J Gastroenterol. 1988 Dec;83(12):1395-7. PMID: 2848410.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Chejfec G., Jablokow V.R., Gould V.E. Linitis plastica carcinoma of the esophagus. Cancer. 1983 Jun 1;51(11):2139-43. doi: 10.1002/1097-0142(19830601)51:11&lt;2139:: aid-cncr 2820511131&gt;3.0.co;2-y.</mixed-citation><mixed-citation xml:lang="en">Chejfec G., Jablokow V.R., Gould V.E. Linitis plastica carcinoma of the esophagus. Cancer. 1983 Jun 1;51(11):2139-43. doi: 10.1002/1097-0142(19830601)51:11&lt;2139:: aid-cncr 2820511131&gt;3.0.co;2-y.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Hamid K., Hamza M., Rezac L., Shrestha A. Linitis Plastica. S D Med. 2022 Aug; 75 (8): 375. PMID: 36745987.</mixed-citation><mixed-citation xml:lang="en">Hamid K., Hamza M., Rezac L., Shrestha A. Linitis Plastica. S D Med. 2022 Aug; 75 (8): 375. PMID: 36745987.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Nazareno J., Taves D., Preiksaitis H.G. Metastatic breast cancer to the gastrointestinal tract: a case series and review of the literature. World J Gastroenterol. 2006 Oct 14; 12(38): 6219-24. doi: 10.3748/wjg.v12.i38.6219.</mixed-citation><mixed-citation xml:lang="en">Nazareno J., Taves D., Preiksaitis H.G. Metastatic breast cancer to the gastrointestinal tract: a case series and review of the literature. World J Gastroenterol. 2006 Oct 14; 12(38): 6219-24. doi: 10.3748/wjg.v12.i38.6219.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Aoki H., Kawada H., Hanabata Y. et al. Diffusely infiltrative squamous cell carcinoma of the esophagus resembling scirrhous gastric cancer: a case report. Ann Med Surg (Lond). 2023 Feb 7; 85(2):266-270. doi: 10.1097/MS9.0000000000000187.</mixed-citation><mixed-citation xml:lang="en">Aoki H., Kawada H., Hanabata Y. et al. Diffusely infiltrative squamous cell carcinoma of the esophagus resembling scirrhous gastric cancer: a case report. Ann Med Surg (Lond). 2023 Feb 7; 85(2):266-270. doi: 10.1097/MS9.0000000000000187.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Habib A., Kumari A., Nazir Z. et al. Revolutionizing gastric linitis plastica diagnosis: the crucial role of EUS-FNA in a sequential diagnostic approach.Int J Surg. 2024 May 1; 110(5): 2529-2531. doi: 10.1097/JS9.0000000000001209.</mixed-citation><mixed-citation xml:lang="en">Habib A., Kumari A., Nazir Z. et al. Revolutionizing gastric linitis plastica diagnosis: the crucial role of EUS-FNA in a sequential diagnostic approach.Int J Surg. 2024 May 1; 110(5): 2529-2531. doi: 10.1097/JS9.0000000000001209.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Castellanos González M., Delgado Martínez C., Pérez-Bedmar Delgado J. Stenosing oesophageal carcinoma diagnosed endoscopically by gastrostomy. Gastroenterol Hepatol. 2018 Oct; 41(8): 512-513. English, Spanish. doi: 10.1016/j.gastrohep.2018.04.004.</mixed-citation><mixed-citation xml:lang="en">Castellanos González M., Delgado Martínez C., Pérez-Bedmar Delgado J. Stenosing oesophageal carcinoma diagnosed endoscopically by gastrostomy. Gastroenterol Hepatol. 2018 Oct; 41(8): 512-513. English, Spanish. doi: 10.1016/j.gastrohep.2018.04.004.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
