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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-230-10-62-70</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-3001</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРАКТИЧЕСКИЕ РЕКОМЕНДАЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PRACTICAL GUIDELINES</subject></subj-group></article-categories><title-group><article-title>Неалкогольная жировая болезнь печени и артериальная гипертензия: двунаправленная взаимоотягощающая связь</article-title><trans-title-group xml:lang="en"><trans-title>Non-alcoholic fatty liver disease and hypertension: a bidirectional, mutually aggravating relationship</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8736-5851</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лазебник</surname><given-names>Л. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Lazebnik</surname><given-names>L. B.</given-names></name></name-alternatives><email xlink:type="simple">leonid.borisl@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8844-2465</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Туркина</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Turkina</surname><given-names>S. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Российский университет медицины» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow State University of Medicine and Dentistry</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Волгоградский государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Volgograd State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>10</day><month>12</month><year>2024</year></pub-date><volume>0</volume><issue>10</issue><fpage>62</fpage><lpage>70</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лазебник Л.Б., Туркина С.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Лазебник Л.Б., Туркина С.В.</copyright-holder><copyright-holder xml:lang="en">Lazebnik L.B., Turkina S.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/3001">https://www.nogr.org/jour/article/view/3001</self-uri><abstract><p>Данная статья представляет блок клинических рекомендаций по ведению пациентов с неалкогольной жировой болезнью печени (НАЖБП), раздел по особенностям ведения пациентов с НАЖБП и сопутствующей артериальной гипертензии (АГ). В обзоре рассмотрены патогенетические связи формирования АГ у пациентов с НАЖБП. Приведены результаты многоцентровых исследований и метаанализов, демонстрирующих связь между данными заболеваниями. Рассмотрены основные направления диагностики и особенности антигипертензивной терапии у этой категории пациентов.</p></abstract><trans-abstract xml:lang="en"><p>This article presents a set of clinical guidelines for the management of patients with non-alcoholic fatty liver disease (NAFLD), a section on the specifics of managing patients with NAFLD and concomitant arterial hypertension (AH). The review examines the pathogenetic relationships of hypertension development in patients with NAFLD. The results of multicenter studies and meta-analyses demonstrating the relationship between these diseases are presented. The main directions of diagnostics and features of antihypertensive therapy in this category of patients are considered.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>неалкогольная жировая болезнь печени</kwd><kwd>артериальная гипертензия</kwd><kwd>антигипертензивная терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>non-alcoholic fatty liver disease</kwd><kwd>arterial hypertension</kwd><kwd>antihypertensive therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ng C.H., Wong Z.Y., Chew N.W.S. et al. Hypertension is prevalent in non-alcoholic fatty liver disease and increases all-cause and cardiovascular mortality. Front Cardiovasc Med. 2022;9:942753. doi: 10.3389/fcvm.2022.942753.</mixed-citation><mixed-citation xml:lang="en">Ng C.H., Wong Z.Y., Chew N.W.S. et al. Hypertension is prevalent in non-alcoholic fatty liver disease and increases all-cause and cardiovascular mortality. Front Cardiovasc Med. 2022;9:942753. doi: 10.3389/fcvm.2022.942753.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Lorbeer R., Bayerl C., Auweter S. et.al. Association between MRI-derived hepatic fat fraction and blood pressure in participants without history of cardiovascular disease. J Hypertens. 2017;35(4):737-744. doi: 10.1097/HJH.0000000000001245.</mixed-citation><mixed-citation xml:lang="en">Lorbeer R., Bayerl C., Auweter S. et.al. Association between MRI-derived hepatic fat fraction and blood pressure in participants without history of cardiovascular disease. J Hypertens. 2017;35(4):737-744. doi: 10.1097/HJH.0000000000001245.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Fallo F., Dalla Pozza A., Sonino N. et al. Nonalcoholic fatty liver disease, adiponectin and insulin resistance in dipper and nondipper essential hypertensive patients. J Hypertens. 2008;26(11):2191-7. doi: 10.1097/HJH.0b013e32830dfe4b.</mixed-citation><mixed-citation xml:lang="en">Fallo F., Dalla Pozza A., Sonino N. et al. Nonalcoholic fatty liver disease, adiponectin and insulin resistance in dipper and nondipper essential hypertensive patients. J Hypertens. 2008;26(11):2191-7. doi: 10.1097/HJH.0b013e32830dfe4b.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Latea L., Negrea S., Bolboaca S. Primary non-alcoholic fatty liver disease in hypertensive patients. AustralasMed J. 2013;6(6):325-30. doi: 10.4066/AMJ.2013.1648.</mixed-citation><mixed-citation xml:lang="en">Latea L., Negrea S., Bolboaca S. Primary non-alcoholic fatty liver disease in hypertensive patients. AustralasMed J. 2013;6(6):325-30. doi: 10.4066/AMJ.2013.1648.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Vasunta R.L., Kesäniemi Y.A., Ylitalo A.S., Ukkola O.H. High ambulatory blood pressure values associated with non-alcoholic fatty liver in middle-aged adults. J Hypertens. 2012;30(10):2015-9. doi: 10.1097/HJH.0b013e3283576faf.</mixed-citation><mixed-citation xml:lang="en">Vasunta R.L., Kesäniemi Y.A., Ylitalo A.S., Ukkola O.H. High ambulatory blood pressure values associated with non-alcoholic fatty liver in middle-aged adults. J Hypertens. 2012;30(10):2015-9. doi: 10.1097/HJH.0b013e3283576faf.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ryoo J.H., Suh Y.J., Shin H.C. et al. Clinical association between non-alcoholic fatty liver disease and the development of hypertension. J Gastroenterol Hepatol. 2014;29(11):1926-31. doi: 10.1111/jgh.12643.</mixed-citation><mixed-citation xml:lang="en">Ryoo J.H., Suh Y.J., Shin H.C. et al. Clinical association between non-alcoholic fatty liver disease and the development of hypertension. J Gastroenterol Hepatol. 2014;29(11):1926-31. doi: 10.1111/jgh.12643.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Sung K.C., Wild S.H., Byrne C.D. Development of new fatty liver, or resolution of existing fatty liver, over five years of follow-up, and risk of incident hypertension. J Hepatol. 2014;60(5):1040-5. doi: 10.1016/j.jhep.2014.01.009.</mixed-citation><mixed-citation xml:lang="en">Sung K.C., Wild S.H., Byrne C.D. Development of new fatty liver, or resolution of existing fatty liver, over five years of follow-up, and risk of incident hypertension. J Hepatol. 2014;60(5):1040-5. doi: 10.1016/j.jhep.2014.01.009.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Huh J.H., Ahn S.V., Koh S.B. et al. Prospective Study of Fatty Liver Index and Incident Hypertension: The KoGES-ARIRANG Study. PLoS One. 2015;10(11): e0143560. doi: 10.1371/journal.pone.0143560.</mixed-citation><mixed-citation xml:lang="en">Huh J.H., Ahn S.V., Koh S.B. et al. Prospective Study of Fatty Liver Index and Incident Hypertension: The KoGES-ARIRANG Study. PLoS One. 2015;10(11): e0143560. doi: 10.1371/journal.pone.0143560.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Liu P., Tang Y., Guo X. et al. Bidirectional association between nonalcoholic fatty liver disease and hypertension from the Dongfeng-Tongji cohort study. J Am Soc Hypertens. 2018;12(9):660-670. doi: 10.1016/j.jash.2018.06.013.</mixed-citation><mixed-citation xml:lang="en">Liu P., Tang Y., Guo X. et al. Bidirectional association between nonalcoholic fatty liver disease and hypertension from the Dongfeng-Tongji cohort study. J Am Soc Hypertens. 2018;12(9):660-670. doi: 10.1016/j.jash.2018.06.013.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Roh J.H., Park J.H., Lee H. et al. A Close Relationship between Non-Alcoholic Fatty Liver Disease Marker and New-Onset Hypertension in Healthy Korean Adults. Korean Circ J. 2020;50(8):695-705. doi: 10.4070/kcj.2019.0379.</mixed-citation><mixed-citation xml:lang="en">Roh J.H., Park J.H., Lee H. et al. A Close Relationship between Non-Alcoholic Fatty Liver Disease Marker and New-Onset Hypertension in Healthy Korean Adults. Korean Circ J. 2020;50(8):695-705. doi: 10.4070/kcj.2019.0379.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao Y.C., Zhao G.J., Chen Z. et al. Nonalcoholic Fatty Liver Disease: An Emerging Driver of Hypertension. Hypertension. 2020 Feb;75(2):275-284. doi: 10.1161/HYPERTENSIONAHA.119.13419.</mixed-citation><mixed-citation xml:lang="en">Zhao Y.C., Zhao G.J., Chen Z. et al. Nonalcoholic Fatty Liver Disease: An Emerging Driver of Hypertension. Hypertension. 2020 Feb;75(2):275-284. doi: 10.1161/HYPERTENSIONAHA.119.13419.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Higashiura Y., Furuhashi M., Tanaka M. et al. Elevated Fatty Liver Index Is Independently Associated With New Onset of Hypertension During a 10-Year Period in Both Male and Female Subjects. J Am Heart Assoc. 2021;10(14): e021430. doi: 10.1161/JAHA.121.021430.</mixed-citation><mixed-citation xml:lang="en">Higashiura Y., Furuhashi M., Tanaka M. et al. Elevated Fatty Liver Index Is Independently Associated With New Onset of Hypertension During a 10-Year Period in Both Male and Female Subjects. J Am Heart Assoc. 2021;10(14): e021430. doi: 10.1161/JAHA.121.021430.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Ciardullo S., Grassi G., Mancia G., Perseghin G. Nonalcoholic fatty liver disease and risk of incident hypertension: a systematic review and meta-analysis. Eur J Gastroenterol Hepatol. 2022;34(4):365-371. doi: 10.1097/MEG.0000000000002299.</mixed-citation><mixed-citation xml:lang="en">Ciardullo S., Grassi G., Mancia G., Perseghin G. Nonalcoholic fatty liver disease and risk of incident hypertension: a systematic review and meta-analysis. Eur J Gastroenterol Hepatol. 2022;34(4):365-371. doi: 10.1097/MEG.0000000000002299.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Chongyang Ma, Kai Yan, Zisong Wang et al. The association between hypertension and nonalcoholic fatty liver disease (NAFLD): literature evidence and systems biology analysis. Bioengineered. 2021;12:1:2187-2202. doi: 10.1080/21655979.2021.1933302.</mixed-citation><mixed-citation xml:lang="en">Chongyang Ma, Kai Yan, Zisong Wang et al. The association between hypertension and nonalcoholic fatty liver disease (NAFLD): literature evidence and systems biology analysis. Bioengineered. 2021;12:1:2187-2202. doi: 10.1080/21655979.2021.1933302.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Вonnet F., Gastaldelli A., Pihan-Le Bars F. et al.; D.E.S.I.R., RISC Study Groups. Gamma-glutamyltransferase, fatty liver index and hepatic insulin resistance are associated with incident hypertension in two longitudinal studies. J Hypertens. 2017;35(3):493-500. doi: 10.1097/HJH.0000000000001204.</mixed-citation><mixed-citation xml:lang="en">Вonnet F., Gastaldelli A., Pihan-Le Bars F. et al.; D.E.S.I.R., RISC Study Groups. Gamma-glutamyltransferase, fatty liver index and hepatic insulin resistance are associated with incident hypertension in two longitudinal studies. J Hypertens. 2017;35(3):493-500. doi: 10.1097/HJH.0000000000001204.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Song Q., Ling Q., Fan L. et al. Severity of non-alcoholic fatty liver disease is a risk factor for developing hypertension from prehypertension. Chin Med J (Engl). 2023;136(13):1591-1597. doi: 10.1097/CM9.0000000000002111.</mixed-citation><mixed-citation xml:lang="en">Song Q., Ling Q., Fan L. et al. Severity of non-alcoholic fatty liver disease is a risk factor for developing hypertension from prehypertension. Chin Med J (Engl). 2023;136(13):1591-1597. doi: 10.1097/CM9.0000000000002111.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Tsuneto A., Hida A., Sera N. et al. Fatty liver incidence and predictive variables. Hypertens Res. 2010;33(6):638-43. doi: 10.1038/hr.2010.45.</mixed-citation><mixed-citation xml:lang="en">Tsuneto A., Hida A., Sera N. et al. Fatty liver incidence and predictive variables. Hypertens Res. 2010;33(6):638-43. doi: 10.1038/hr.2010.45.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Aneni E.C., Oni E.T., Martin S.S. et al. Blood pressure is associated with the presence and severity of nonalcoholic fatty liver disease across the spectrum of cardiometabolic risk. J Hypertens. 2015;33(6):1207-14. doi: 10.1097/HJH.0000000000000532.</mixed-citation><mixed-citation xml:lang="en">Aneni E.C., Oni E.T., Martin S.S. et al. Blood pressure is associated with the presence and severity of nonalcoholic fatty liver disease across the spectrum of cardiometabolic risk. J Hypertens. 2015;33(6):1207-14. doi: 10.1097/HJH.0000000000000532.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Y., Zeng Y., Lin C., Chen Z. Hypertension and non-alcoholic fatty liver disease proven by transient elastography. Hepatol Res. 2016;46(13):1304-1310. doi: 10.1111/hepr.12688.</mixed-citation><mixed-citation xml:lang="en">Wang Y., Zeng Y., Lin C., Chen Z. Hypertension and non-alcoholic fatty liver disease proven by transient elastography. Hepatol Res. 2016;46(13):1304-1310. doi: 10.1111/hepr.12688.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Huang Q., Yu H., Zhong X. et al. Association between hypertension and nonalcoholic fatty liver disease: a cross-sectional and meta-analysis study. J Hum Hypertens. 2023;37(4):313-320. doi: 10.1038/s41371-022-00686-w.</mixed-citation><mixed-citation xml:lang="en">Huang Q., Yu H., Zhong X. et al. Association between hypertension and nonalcoholic fatty liver disease: a cross-sectional and meta-analysis study. J Hum Hypertens. 2023;37(4):313-320. doi: 10.1038/s41371-022-00686-w.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Yuan M., He J., Hu X. et al. Hypertension and NAFLD risk: Insights from the NHANES 2017-2018 and Mendelian randomization analyses. Chin Med J (Engl). 2024;137(4):457-464. doi: 10.1097/CM9.0000000000002753.</mixed-citation><mixed-citation xml:lang="en">Yuan M., He J., Hu X. et al. Hypertension and NAFLD risk: Insights from the NHANES 2017-2018 and Mendelian randomization analyses. Chin Med J (Engl). 2024;137(4):457-464. doi: 10.1097/CM9.0000000000002753.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Gerui Li, Yuanyuan Peng, Ze Chen et al. Bidirectional Association between Hypertension and NAFLD: A Systematic Review and Meta-Analysis of Observational Studies.International Journal of Endocrinology. 2022; vol. 2022, Article ID 8463640, 10 pages. doi: 10.1155/2022/8463640.</mixed-citation><mixed-citation xml:lang="en">Gerui Li, Yuanyuan Peng, Ze Chen et al. Bidirectional Association between Hypertension and NAFLD: A Systematic Review and Meta-Analysis of Observational Studies.International Journal of Endocrinology. 2022; vol. 2022, Article ID 8463640, 10 pages. doi: 10.1155/2022/8463640.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Sorrentino P., Terracciano L., D’Angelo S. et al. Predicting fibrosis worsening in obese patients with NASH through parenchymal fibronectin, HOMA-IR, and hypertension. Am J Gastroenterol. 2010;105(2):336-44. doi: 10.1038/ajg.2009.587.</mixed-citation><mixed-citation xml:lang="en">Sorrentino P., Terracciano L., D’Angelo S. et al. Predicting fibrosis worsening in obese patients with NASH through parenchymal fibronectin, HOMA-IR, and hypertension. Am J Gastroenterol. 2010;105(2):336-44. doi: 10.1038/ajg.2009.587.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Singh S., Allen A.M., Wang Z. et al. Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies. Clin Gastroenterol Hepatol. 2015;13(4):643-54.e1-9; quiz e39-40. doi: 10.1016/j.cgh.2014.04.014.</mixed-citation><mixed-citation xml:lang="en">Singh S., Allen A.M., Wang Z. et al. Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies. Clin Gastroenterol Hepatol. 2015;13(4):643-54.e1-9; quiz e39-40. doi: 10.1016/j.cgh.2014.04.014.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Labenz C., Huber Y., Kalliga E. et al. Predictors of advanced fibrosis in non-cirrhotic non-alcoholic fatty liver disease in Germany. Aliment PharmacolTher. 2018;48(10):1109-1116. doi: 10.1111/apt.14976.</mixed-citation><mixed-citation xml:lang="en">Labenz C., Huber Y., Kalliga E. et al. Predictors of advanced fibrosis in non-cirrhotic non-alcoholic fatty liver disease in Germany. Aliment PharmacolTher. 2018;48(10):1109-1116. doi: 10.1111/apt.14976.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Gawrieh S., Wilson L.A., Cummings O.W. et al. NASH Clinical Research Network. Histologic Findings of Advanced Fibrosis and Cirrhosis in Patients With Nonalcoholic Fatty Liver Disease Who Have Normal Aminotransferase Levels. Am J Gastroenterol. 2019;114(10):1626-1635. doi: 10.14309/ajg.0000000000000388.</mixed-citation><mixed-citation xml:lang="en">Gawrieh S., Wilson L.A., Cummings O.W. et al. NASH Clinical Research Network. Histologic Findings of Advanced Fibrosis and Cirrhosis in Patients With Nonalcoholic Fatty Liver Disease Who Have Normal Aminotransferase Levels. Am J Gastroenterol. 2019;114(10):1626-1635. doi: 10.14309/ajg.0000000000000388.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Kanwal F., Kramer J.R., Li L., Dai J. et al. Effect of Metabolic Traits on the Risk of Cirrhosis and Hepatocellular Cancer in Nonalcoholic Fatty Liver Disease. Hepatology. 2020;71(3):808-819. doi: 10.1002/hep.31014.</mixed-citation><mixed-citation xml:lang="en">Kanwal F., Kramer J.R., Li L., Dai J. et al. Effect of Metabolic Traits on the Risk of Cirrhosis and Hepatocellular Cancer in Nonalcoholic Fatty Liver Disease. Hepatology. 2020;71(3):808-819. doi: 10.1002/hep.31014.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Jaruvongvanich V., Wirunsawanya K., Sanguankeo A., Upala S. Nonalcoholic fatty liver disease is associated with coronary artery calcification: A systematic review and meta-analysis. Dig Liver Dis. 2016;48(12):1410-1417. doi: 10.1016/j.dld.2016.09.002.</mixed-citation><mixed-citation xml:lang="en">Jaruvongvanich V., Wirunsawanya K., Sanguankeo A., Upala S. Nonalcoholic fatty liver disease is associated with coronary artery calcification: A systematic review and meta-analysis. Dig Liver Dis. 2016;48(12):1410-1417. doi: 10.1016/j.dld.2016.09.002.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Mahfood Haddad T., Hamdeh S., Kanmanthareddy A., Alla V.M. Nonalcoholic fatty liver disease and the risk of clinical cardiovascular events: A systematic review and meta-analysis. Diabetes MetabSyndr. 2017;11 Suppl 1: S209-S216. doi: 10.1016/j.dsx.2016.12.033.</mixed-citation><mixed-citation xml:lang="en">Mahfood Haddad T., Hamdeh S., Kanmanthareddy A., Alla V.M. Nonalcoholic fatty liver disease and the risk of clinical cardiovascular events: A systematic review and meta-analysis. Diabetes MetabSyndr. 2017;11 Suppl 1: S209-S216. doi: 10.1016/j.dsx.2016.12.033.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Zhou Y.Y., Zhou X.D., Wu S.J. et al. Nonalcoholic fatty liver disease contributes to subclinical atherosclerosis: A systematic review and meta-analysis. Hepatol Commun. 2018;2(4):376-392. doi: 10.1002/hep4.1155.</mixed-citation><mixed-citation xml:lang="en">Zhou Y.Y., Zhou X.D., Wu S.J. et al. Nonalcoholic fatty liver disease contributes to subclinical atherosclerosis: A systematic review and meta-analysis. Hepatol Commun. 2018;2(4):376-392. doi: 10.1002/hep4.1155.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Wong M.Y.Z., Yap J.J.L., Sultana R. et al. Association between non-alcoholic fatty liver disease and subclinical atherosclerosis in Western and Asian cohorts: an updated meta-analysis. Open Heart. 2021;8(2): e001850. doi: 10.1136/openhrt-2021-001850.</mixed-citation><mixed-citation xml:lang="en">Wong M.Y.Z., Yap J.J.L., Sultana R. et al. Association between non-alcoholic fatty liver disease and subclinical atherosclerosis in Western and Asian cohorts: an updated meta-analysis. Open Heart. 2021;8(2): e001850. doi: 10.1136/openhrt-2021-001850.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Duell P.B., Welty F.K., Miller M., et al; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Hypertension; Council on the Kidney in Cardiovascular Disease; Council on Lifestyle and Cardiometabolic Health; and Council on Peripheral Vascular Disease. Nonalcoholic Fatty Liver Disease and Cardiovascular Risk: A Scientific Statement From the American Heart Association. Arterioscler Thromb Vasc Biol. 2022;42(6): e168-e185. doi: 10.1161/ATV.0000000000000153.</mixed-citation><mixed-citation xml:lang="en">Duell P.B., Welty F.K., Miller M., et al; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Hypertension; Council on the Kidney in Cardiovascular Disease; Council on Lifestyle and Cardiometabolic Health; and Council on Peripheral Vascular Disease. Nonalcoholic Fatty Liver Disease and Cardiovascular Risk: A Scientific Statement From the American Heart Association. Arterioscler Thromb Vasc Biol. 2022;42(6): e168-e185. doi: 10.1161/ATV.0000000000000153.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Hassen G., Singh A., Belete G. et al. Nonalcoholic Fatty Liver Disease: An Emerging Modern-Day Risk Factor for Cardiovascular Disease. Cureus. 2022;14(5): e25495. doi: 10.7759/cureus.25495.</mixed-citation><mixed-citation xml:lang="en">Hassen G., Singh A., Belete G. et al. Nonalcoholic Fatty Liver Disease: An Emerging Modern-Day Risk Factor for Cardiovascular Disease. Cureus. 2022;14(5): e25495. doi: 10.7759/cureus.25495.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Kjeldsen S.E. Hypertension and cardiovascular risk: General aspects. Pharmacol Res. 2018;129:95-99. doi: 10.1016/j.phrs.2017.11.003.</mixed-citation><mixed-citation xml:lang="en">Kjeldsen S.E. Hypertension and cardiovascular risk: General aspects. Pharmacol Res. 2018;129:95-99. doi: 10.1016/j.phrs.2017.11.003.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Dolgalev I.V., Ivanova A. Yu., Shipkhineeva A. Yu. Hypertension as a death risk factor in men and women aged 20-59 years: a 34-year cohort prospective study. Cardiovascular Therapy and Prevention. 2023;22(8):3602. (In Russ.) doi: 10.15829/1728-8800-2023-3602.@@ Долгалев И.В., Иванова А.Ю., Шипхинеева А.Ю. Артериальная гипертензия как фактор риска смерти у мужчин и женщин в возрасте 20-59 лет: 34-летнее когортное проспективное исследование. Кардиоваскулярная терапия и профилактика. 2023;22(8):3602. doi: 10.15829/1728-8800-2023-3602.</mixed-citation><mixed-citation xml:lang="en">Dolgalev I.V., Ivanova A. Yu., Shipkhineeva A. Yu. Hypertension as a death risk factor in men and women aged 20-59 years: a 34-year cohort prospective study. Cardiovascular Therapy and Prevention. 2023;22(8):3602. (In Russ.) doi: 10.15829/1728-8800-2023-3602.@@ Долгалев И.В., Иванова А.Ю., Шипхинеева А.Ю. Артериальная гипертензия как фактор риска смерти у мужчин и женщин в возрасте 20-59 лет: 34-летнее когортное проспективное исследование. Кардиоваскулярная терапия и профилактика. 2023;22(8):3602. doi: 10.15829/1728-8800-2023-3602.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Martín-Fernández J., Alonso-Safont T., Polentinos-Castro E. et al. Impact of hypertension diagnosis on morbidity and mortality: a retrospective cohort study in primary care. BMC Prim Care. 2023 Mar 23;24(1):79. doi: 10.1186/s12875-023-02036-2.</mixed-citation><mixed-citation xml:lang="en">Martín-Fernández J., Alonso-Safont T., Polentinos-Castro E. et al. Impact of hypertension diagnosis on morbidity and mortality: a retrospective cohort study in primary care. BMC Prim Care. 2023 Mar 23;24(1):79. doi: 10.1186/s12875-023-02036-2.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Kuneinen S.M., Kautiainen H., Ekblad M.O., Korhonen P.E. Multifactorial prevention program for cardiovascular disease in primary care: hypertension status and effect on mortality. J Hum Hypertens. 2024;38(4):322-328. doi: 10.1038/s41371-024-00900-x.</mixed-citation><mixed-citation xml:lang="en">Kuneinen S.M., Kautiainen H., Ekblad M.O., Korhonen P.E. Multifactorial prevention program for cardiovascular disease in primary care: hypertension status and effect on mortality. J Hum Hypertens. 2024;38(4):322-328. doi: 10.1038/s41371-024-00900-x.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Lonardo A., Nascimbeni F., Mantovani A., Targher G. Hypertension, diabetes, atherosclerosis and NASH: Cause or consequence? J. Hepatol. 2018;68:335-352. doi: 10.1016/j.jhep.2017.09.021.</mixed-citation><mixed-citation xml:lang="en">Lonardo A., Nascimbeni F., Mantovani A., Targher G. Hypertension, diabetes, atherosclerosis and NASH: Cause or consequence? J. Hepatol. 2018;68:335-352. doi: 10.1016/j.jhep.2017.09.021.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Song Q.R., Liu S.L., Ling Q.H. et al. Severity of Nonalcoholic Fatty Liver Disease is Associated With Cardiovascular Outcomes in Patients With Prehypertension or Hypertension: A Community-Based Cohort Study. Front Endocrinol (Lausanne). 2022; 13:942647. doi: 10.3389/fendo.2022.942647.</mixed-citation><mixed-citation xml:lang="en">Song Q.R., Liu S.L., Ling Q.H. et al. Severity of Nonalcoholic Fatty Liver Disease is Associated With Cardiovascular Outcomes in Patients With Prehypertension or Hypertension: A Community-Based Cohort Study. Front Endocrinol (Lausanne). 2022; 13:942647. doi: 10.3389/fendo.2022.942647.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Cattazzo F., Lombardi R., Mantovani A. et al. Subclinical and clinical atherosclerosis in non-alcoholic fatty liver disease is associated with the presence of hypertension. Nutr Metab Cardiovasc Dis. 2022;32(12):2839-2847. doi: 10.1016/j.numecd.2022.08.005.</mixed-citation><mixed-citation xml:lang="en">Cattazzo F., Lombardi R., Mantovani A. et al. Subclinical and clinical atherosclerosis in non-alcoholic fatty liver disease is associated with the presence of hypertension. Nutr Metab Cardiovasc Dis. 2022;32(12):2839-2847. doi: 10.1016/j.numecd.2022.08.005.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Bataller R., Sancho-Bru P., Ginès P. et al. Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II. Gastroenterology. 2003;125:117-125. doi: 10.1016/s0016-5085(03)00695-4.</mixed-citation><mixed-citation xml:lang="en">Bataller R., Sancho-Bru P., Ginès P. et al. Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II. Gastroenterology. 2003;125:117-125. doi: 10.1016/s0016-5085(03)00695-4.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Warner F.J., Lubel J.S., McCaughan G.W., Angus P.W. Liver fibrosis: a balance of ACEs? Clin Sci (Lond). 2007; 113:109-118. doi: 10.1042/CS20070026.</mixed-citation><mixed-citation xml:lang="en">Warner F.J., Lubel J.S., McCaughan G.W., Angus P.W. Liver fibrosis: a balance of ACEs? Clin Sci (Lond). 2007; 113:109-118. doi: 10.1042/CS20070026.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Sigala B., McKee C., Soeda J. et al. Sympathetic nervous system catecholamines and neuropeptide Y neurotransmitters are upregulated in human NAFLD and modulate the fibrogenic function of hepatic stellate cells. PLoS One. 2013;8: e72928. doi: 10.1371/journal.pone.0072928.</mixed-citation><mixed-citation xml:lang="en">Sigala B., McKee C., Soeda J. et al. Sympathetic nervous system catecholamines and neuropeptide Y neurotransmitters are upregulated in human NAFLD and modulate the fibrogenic function of hepatic stellate cells. PLoS One. 2013;8: e72928. doi: 10.1371/journal.pone.0072928.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Lee H.J., Lee C.H., Kim S. et al. Association between vascular inflammation and non-alcoholic fatty liver disease: analysis by 18F-fluorodeoxyglucose positron emission tomography. Metabolism. 2017;67:72-79. doi: 10.1016/j.metabol.2016.11.004.</mixed-citation><mixed-citation xml:lang="en">Lee H.J., Lee C.H., Kim S. et al. Association between vascular inflammation and non-alcoholic fatty liver disease: analysis by 18F-fluorodeoxyglucose positron emission tomography. Metabolism. 2017;67:72-79. doi: 10.1016/j.metabol.2016.11.004.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Mattson D.L. Immune mechanisms of salt-sensitive hypertension and renal end-organ damage. Nat Rev Nephrol. 2019;15:290-300. doi: 10.1038/s41581-019-0121-z.</mixed-citation><mixed-citation xml:lang="en">Mattson D.L. Immune mechanisms of salt-sensitive hypertension and renal end-organ damage. Nat Rev Nephrol. 2019;15:290-300. doi: 10.1038/s41581-019-0121-z.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">[Chronic kidney disease (CKD)]. Clinical guidelines Ministry of Health of the Russian Federation 2024. ID: 469. (in Russ.) Available at: https://cr.minzdrav.gov.ru/recomend/469_3 (Accessed: 05.09.2024.)@@ Хроническая болезнь почек (ХБП). Клинические рекомендации Министерства здравоохранения РФ. ID: 469, 2024. https://cr.minzdrav.gov.ru/recomend/469_3</mixed-citation><mixed-citation xml:lang="en">[Chronic kidney disease (CKD)]. Clinical guidelines Ministry of Health of the Russian Federation 2024. ID: 469. (in Russ.) Available at: https://cr.minzdrav.gov.ru/recomend/469_3 (Accessed: 05.09.2024.)@@ Хроническая болезнь почек (ХБП). Клинические рекомендации Министерства здравоохранения РФ. ID: 469, 2024. https://cr.minzdrav.gov.ru/recomend/469_3</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Goalstone M.L., Natarajan R., Standley P.R. et al. Insulin potentiates platelet-derived growth factor action in vascular smooth muscle cells. Endocrinology. 1998 Oct;139(10):4067-72. doi: 10.1210/endo.139.10.6270</mixed-citation><mixed-citation xml:lang="en">Goalstone M.L., Natarajan R., Standley P.R. et al. Insulin potentiates platelet-derived growth factor action in vascular smooth muscle cells. Endocrinology. 1998 Oct;139(10):4067-72. doi: 10.1210/endo.139.10.6270</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Macvanin M., Gluvic Z., Radovanovic J. et al. New insights on the cardiovascular effects of IGF-1. Front Endocrinol (Lausanne). 2023 Feb 9;14:1142644. doi: 10.3389/fendo.2023.1142644.</mixed-citation><mixed-citation xml:lang="en">Macvanin M., Gluvic Z., Radovanovic J. et al. New insights on the cardiovascular effects of IGF-1. Front Endocrinol (Lausanne). 2023 Feb 9;14:1142644. doi: 10.3389/fendo.2023.1142644.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang Y., Zhang X.J., Wang P.X. et al. Reprogramming innate immune signaling in cardiometabolic disease. Hypertension. 2017;69:747-760. doi: 10.1161/HYPERTENSIONAHA.116.0819.</mixed-citation><mixed-citation xml:lang="en">Zhang Y., Zhang X.J., Wang P.X. et al. Reprogramming innate immune signaling in cardiometabolic disease. Hypertension. 2017;69:747-760. doi: 10.1161/HYPERTENSIONAHA.116.0819.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Brandes R.P. Endothelial dysfunction and hypertension. Hypertension. 2014;64:924-928. doi: 10.1161/HYPERTENSIONAHA.114.03575.</mixed-citation><mixed-citation xml:lang="en">Brandes R.P. Endothelial dysfunction and hypertension. Hypertension. 2014;64:924-928. doi: 10.1161/HYPERTENSIONAHA.114.03575.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Cai J., Xu M., Zhang X., Li H. Innate immune signaling in nonalcoholic fatty liver disease and cardiovascular diseases. Annu Rev Pathol. 2019;14:153-184. doi: 10.1146/annurev-pathmechdis-012418-013003.</mixed-citation><mixed-citation xml:lang="en">Cai J., Xu M., Zhang X., Li H. Innate immune signaling in nonalcoholic fatty liver disease and cardiovascular diseases. Annu Rev Pathol. 2019;14:153-184. doi: 10.1146/annurev-pathmechdis-012418-013003.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Cai J., Zhang X.J., Li H. Role of innate immune signaling in non-alcoholic fatty liver disease. Trends Endocrinol Metab. 2018;29:712-722. doi: 10.1016/j.tem.2018.08.003.</mixed-citation><mixed-citation xml:lang="en">Cai J., Zhang X.J., Li H. Role of innate immune signaling in non-alcoholic fatty liver disease. Trends Endocrinol Metab. 2018;29:712-722. doi: 10.1016/j.tem.2018.08.003.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Swiderska M., Maciejczyk M., Zalewska A. et al. A. Oxidative stress biomarkers in the serum and plasma of patients with non-alcoholic fatty liver disease (NAFLD). Can plasma AGE be a marker of NAFLD? Oxidative stress biomarkers in NAFLD patients. Free Radic Res. 2019:1-10. doi: 10.1080/10715762.2019.1635691.</mixed-citation><mixed-citation xml:lang="en">Swiderska M., Maciejczyk M., Zalewska A. et al. A. Oxidative stress biomarkers in the serum and plasma of patients with non-alcoholic fatty liver disease (NAFLD). Can plasma AGE be a marker of NAFLD? Oxidative stress biomarkers in NAFLD patients. Free Radic Res. 2019:1-10. doi: 10.1080/10715762.2019.1635691.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Guzik T.J., Touyz R.M. Oxidative stress, inflammation, and vascular aging in hypertension. Hypertension. 2017;70:660-667. doi: 10.1161/HYPERTENSIONAHA.117.0780.</mixed-citation><mixed-citation xml:lang="en">Guzik T.J., Touyz R.M. Oxidative stress, inflammation, and vascular aging in hypertension. Hypertension. 2017;70:660-667. doi: 10.1161/HYPERTENSIONAHA.117.0780.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Adolph T.E., Grande C., Grabherr F., Tilg H. Adipokines and non-alcoholic fatty liver disease: multiple interactions.Int J Mol Sci. 2017;18: e1649. doi: 10.3390/ijms18081649.</mixed-citation><mixed-citation xml:lang="en">Adolph T.E., Grande C., Grabherr F., Tilg H. Adipokines and non-alcoholic fatty liver disease: multiple interactions.Int J Mol Sci. 2017;18: e1649. doi: 10.3390/ijms18081649.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Roja E., Rodríguez-Molina D., Bolli P. et al. The role of adiponectin in endothelial dysfunction and hypertension. Curr Hypertens Rep. 2014;16:463. doi: 10.1007/s11906-014-0463-7.</mixed-citation><mixed-citation xml:lang="en">Roja E., Rodríguez-Molina D., Bolli P. et al. The role of adiponectin in endothelial dysfunction and hypertension. Curr Hypertens Rep. 2014;16:463. doi: 10.1007/s11906-014-0463-7.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Faulkner J.L., Belin de Chantemèle E.J. Sex differences in mechanisms of hypertension associated with obesity. Hypertension. 2018;71:15-21. doi: 10.1161/HYPERTENSIONAHA.117.09980.</mixed-citation><mixed-citation xml:lang="en">Faulkner J.L., Belin de Chantemèle E.J. Sex differences in mechanisms of hypertension associated with obesity. Hypertension. 2018;71:15-21. doi: 10.1161/HYPERTENSIONAHA.117.09980.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Cao Z., Cheng Y., Li S. et al. Mediation of the effect of serum uric acid on the risk of developing hypertension: a population-based cohort study. J Transl Med. 2019;17(1):202. doi: 10.1186/s12967-019-1953-9.</mixed-citation><mixed-citation xml:lang="en">Cao Z., Cheng Y., Li S. et al. Mediation of the effect of serum uric acid on the risk of developing hypertension: a population-based cohort study. J Transl Med. 2019;17(1):202. doi: 10.1186/s12967-019-1953-9.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Feig D.I. The role of uric acid in the pathogenesis of hypertension in the young. J Clin Hypertens (Greenwich). 2012;14(6):346-52. doi: 10.1111/j.1751-7176.2012.00662.x.</mixed-citation><mixed-citation xml:lang="en">Feig D.I. The role of uric acid in the pathogenesis of hypertension in the young. J Clin Hypertens (Greenwich). 2012;14(6):346-52. doi: 10.1111/j.1751-7176.2012.00662.x.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Jaruvongvanich V., Ahuja W., Wirunsawanya K., Wijarnpreecha K., Ungprasert P. Hyperuricemia is associated with nonalcoholic fatty liver disease activity score in patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis. Eur J Gastroenterol Hepatol. 2017;29(9):1031-1035. doi: 10.1097/MEG.0000000000000931.</mixed-citation><mixed-citation xml:lang="en">Jaruvongvanich V., Ahuja W., Wirunsawanya K., Wijarnpreecha K., Ungprasert P. Hyperuricemia is associated with nonalcoholic fatty liver disease activity score in patients with nonalcoholic fatty liver disease: a systematic review and meta-analysis. Eur J Gastroenterol Hepatol. 2017;29(9):1031-1035. doi: 10.1097/MEG.0000000000000931.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Sun Q., Zhang T., Manji L. et al. Association Between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: An Updated Systematic Review and Meta-Analysis. Clin Epidemiol. 2023;15:683-693. doi: 10.2147/CLEP.S403314.</mixed-citation><mixed-citation xml:lang="en">Sun Q., Zhang T., Manji L. et al. Association Between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: An Updated Systematic Review and Meta-Analysis. Clin Epidemiol. 2023;15:683-693. doi: 10.2147/CLEP.S403314.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Abbasi S., Haleem N., Jadoon S., Farooq A. Association Of Non-Alcoholic Fatty Liver Disease With Serum Uric Acid. J Ayub Med Coll Abbottabad. 2019;31(1):64-66. PMID: 30868786.</mixed-citation><mixed-citation xml:lang="en">Abbasi S., Haleem N., Jadoon S., Farooq A. Association Of Non-Alcoholic Fatty Liver Disease With Serum Uric Acid. J Ayub Med Coll Abbottabad. 2019;31(1):64-66. PMID: 30868786.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Cardiovascular prevention: correction of arterial hypertension, elevated lipid levels, NAFLD as cardiovascular risk factors. Diagnostic and treatment algorithms. Therapy. 2023; 9(4S): 52-86. (In Russ.) doi: 10.18565/therapy.2023.4suppl.52-86.@@ Сердечно-сосудистая профилактика: коррекция артериальной гипертензии, повышенного уровня липидов, НАЖБП как факторов кардиоваскулярного риска. Алгоритмы диагностики и лечения. Терапия. 2023; 9(4S): 52-86. doi: 10.18565/therapy.2023.4suppl.52-86.</mixed-citation><mixed-citation xml:lang="en">Cardiovascular prevention: correction of arterial hypertension, elevated lipid levels, NAFLD as cardiovascular risk factors. Diagnostic and treatment algorithms. Therapy. 2023; 9(4S): 52-86. (In Russ.) doi: 10.18565/therapy.2023.4suppl.52-86.@@ Сердечно-сосудистая профилактика: коррекция артериальной гипертензии, повышенного уровня липидов, НАЖБП как факторов кардиоваскулярного риска. Алгоритмы диагностики и лечения. Терапия. 2023; 9(4S): 52-86. doi: 10.18565/therapy.2023.4suppl.52-86.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Visseren F.L.J., Mach F., Smulders Y.M. et al. ESC National Cardiac Societies; ESC Scientific Document Group. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021;42(34):3227-37. doi: 10.1093/eurheartj/ehab484.</mixed-citation><mixed-citation xml:lang="en">Visseren F.L.J., Mach F., Smulders Y.M. et al. ESC National Cardiac Societies; ESC Scientific Document Group. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021;42(34):3227-37. doi: 10.1093/eurheartj/ehab484.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Clinical guidelines. Non-alcoholic fatty liver disease in adults. All-Russian public organization “Russian Scientific Medical Society of Therapists”, Scientific Society of Gastroenterologists of Russia.Rubricator of clinical guidelines of the Ministry of Health of Russia. 2022. ID: 748. (In Russ.) Available at: https://cr.minzdrav.gov.ru/schema/748_1 (accessed: 05.09.2024.)@@ Клинические рекомендации. Неалкогольная жировая болезнь печени у взрослых. Общероссийская общественная организация «Российское научное медицинское общество терапевтов», Научное общество гастроэнтерологов России. Рубрикатор клинических рекомендаций Минздрава России. 2022. ID: 748. Доступ: https://cr.minzdrav.gov.ru/schema/748_1</mixed-citation><mixed-citation xml:lang="en">Clinical guidelines. Non-alcoholic fatty liver disease in adults. All-Russian public organization “Russian Scientific Medical Society of Therapists”, Scientific Society of Gastroenterologists of Russia.Rubricator of clinical guidelines of the Ministry of Health of Russia. 2022. ID: 748. (In Russ.) Available at: https://cr.minzdrav.gov.ru/schema/748_1 (accessed: 05.09.2024.)@@ Клинические рекомендации. Неалкогольная жировая болезнь печени у взрослых. Общероссийская общественная организация «Российское научное медицинское общество терапевтов», Научное общество гастроэнтерологов России. Рубрикатор клинических рекомендаций Минздрава России. 2022. ID: 748. Доступ: https://cr.minzdrav.gov.ru/schema/748_1</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Ivashkin V.T., Maevskaya M.V., Zharkova M.S. et al. Clinical Practice Guidelines of the Russian Scientific Liver Society, Russian Gastroenterological Association, Russian Association of Endocrinologists, Russian Association of Gerontologists and Geriatricians and National Society for Preventive Cardiology on Diagnosis and Treatment of Non-Alcoholic Liver Disease.Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2022;32(4):104-140. (In Russ.) doi: 10.22416/1382-4376-2022-32-4-104-140.@@ Ивашкин В.Т., Маевская М.В., Жаркова М.С. с соавт. Клинические рекомендации Российского общества по изучению печени, Российской гастроэнтерологической ассоциации, Российской ассоциации эндокринологов, Российской ассоциации геронтологов и гериатров и Национального общества профилактической кардиологии по диагностике и лечению неалкогольной жировой болезни печени. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2022; 32(4): 104-140. doi: 10.22416/1382-4376-2022-32-4-104-140.</mixed-citation><mixed-citation xml:lang="en">Ivashkin V.T., Maevskaya M.V., Zharkova M.S. et al. Clinical Practice Guidelines of the Russian Scientific Liver Society, Russian Gastroenterological Association, Russian Association of Endocrinologists, Russian Association of Gerontologists and Geriatricians and National Society for Preventive Cardiology on Diagnosis and Treatment of Non-Alcoholic Liver Disease.Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2022;32(4):104-140. (In Russ.) doi: 10.22416/1382-4376-2022-32-4-104-140.@@ Ивашкин В.Т., Маевская М.В., Жаркова М.С. с соавт. Клинические рекомендации Российского общества по изучению печени, Российской гастроэнтерологической ассоциации, Российской ассоциации эндокринологов, Российской ассоциации геронтологов и гериатров и Национального общества профилактической кардиологии по диагностике и лечению неалкогольной жировой болезни печени. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2022; 32(4): 104-140. doi: 10.22416/1382-4376-2022-32-4-104-140.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Guan L., Miao P. The effects of taurine supplementation on obesity, blood pressure and lipid profile: A meta-analysis of randomized controlled trials. Eur J Pharmacol. 2020.885. P. 173533. doi: 10.1016/j.ejphar.2020.17353.</mixed-citation><mixed-citation xml:lang="en">Guan L., Miao P. The effects of taurine supplementation on obesity, blood pressure and lipid profile: A meta-analysis of randomized controlled trials. Eur J Pharmacol. 2020.885. P. 173533. doi: 10.1016/j.ejphar.2020.17353.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Sun Q., Wang B., Li Y. et al. Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study. Hypertension. 2016;67(3):541-9. doi: 10.1161/HYPERTENSIONAHA.115.06624.</mixed-citation><mixed-citation xml:lang="en">Sun Q., Wang B., Li Y. et al. Taurine Supplementation Lowers Blood Pressure and Improves Vascular Function in Prehypertension: Randomized, Double-Blind, Placebo-Controlled Study. Hypertension. 2016;67(3):541-9. doi: 10.1161/HYPERTENSIONAHA.115.06624.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Tzang C.C., Lin W.C., Lin L.H. et al. Insights into the cardiovascular benefits of taurine: a systematic review and meta-analysis. Nutr J. 2024 Aug 15;23(1):93. doi: 10.1186/s12937-024-00995-5.</mixed-citation><mixed-citation xml:lang="en">Tzang C.C., Lin W.C., Lin L.H. et al. Insights into the cardiovascular benefits of taurine: a systematic review and meta-analysis. Nutr J. 2024 Aug 15;23(1):93. doi: 10.1186/s12937-024-00995-5.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Tzang C.C., Chi L.Y., Lin L.H., Lin T.Y., Chang K.V., Wu W.T., Özçakar L. Taurine reduces the risk for metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials. Nutr Diabetes. 2024 May 16;14(1):29. doi: 10.1038/s41387-024-00289-z.</mixed-citation><mixed-citation xml:lang="en">Tzang C.C., Chi L.Y., Lin L.H., Lin T.Y., Chang K.V., Wu W.T., Özçakar L. Taurine reduces the risk for metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials. Nutr Diabetes. 2024 May 16;14(1):29. doi: 10.1038/s41387-024-00289-z.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Clinical guidelines. Non-alcoholic fatty liver disease.Rubricator of clinical guidelines of the Ministry of Health of Russia. 2024. ID: 748. (In Russ.) Available at: https://cr.minzdrav.gov.ru/schema/748_1 (Accessed: 05.09.2024.)@@ Клинические рекомендации. Неалкогольная жировая болезнь печени. Рубрикатор клинических рекомендаций Минздрава России. 2024. ID: 748. Доступ: https://cr.minzdrav.gov.ru/schema/748_1</mixed-citation><mixed-citation xml:lang="en">Clinical guidelines. Non-alcoholic fatty liver disease.Rubricator of clinical guidelines of the Ministry of Health of Russia. 2024. ID: 748. (In Russ.) Available at: https://cr.minzdrav.gov.ru/schema/748_1 (Accessed: 05.09.2024.)@@ Клинические рекомендации. Неалкогольная жировая болезнь печени. Рубрикатор клинических рекомендаций Минздрава России. 2024. ID: 748. Доступ: https://cr.minzdrav.gov.ru/schema/748_1</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Li Y., Xu H., Wu W. et al. Clinical application of angiotensin receptor blockers in patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis. Oncotarget. 2018;9(35):24155-24167. doi: 10.18632/oncotarget.23816.</mixed-citation><mixed-citation xml:lang="en">Li Y., Xu H., Wu W. et al. Clinical application of angiotensin receptor blockers in patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis. Oncotarget. 2018;9(35):24155-24167. doi: 10.18632/oncotarget.23816.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Santos R.A., Ferreira A.J., Simoes E.S.A.C. Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis. Exp Physiol. 2008; 93:519-27. doi: 10.1113/expphysiol.2008.042002.</mixed-citation><mixed-citation xml:lang="en">Santos R.A., Ferreira A.J., Simoes E.S.A.C. Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis. Exp Physiol. 2008; 93:519-27. doi: 10.1113/expphysiol.2008.042002.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Santos S.H., Fernandes L.R., Pereira C.S. et al. Increased circulating angiotensin-(1-7) protects white adipose tissue against development of a proinflammatory state stimulated by a high-fat diet. RegulPept. 2012;178:64-70. doi: 10.1016/j.regpep.2012.06.009.</mixed-citation><mixed-citation xml:lang="en">Santos S.H., Fernandes L.R., Pereira C.S. et al. Increased circulating angiotensin-(1-7) protects white adipose tissue against development of a proinflammatory state stimulated by a high-fat diet. RegulPept. 2012;178:64-70. doi: 10.1016/j.regpep.2012.06.009.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Bilman V., Mares-Guia L., Nadu A.P. et al. Decreased hepatic gluconeogenesis in transgenic rats with increased circulating angiotensin-(1-7) Peptides. 2012;37:247-51. doi: 10.1016/j.peptides.2012.08.002.</mixed-citation><mixed-citation xml:lang="en">Bilman V., Mares-Guia L., Nadu A.P. et al. Decreased hepatic gluconeogenesis in transgenic rats with increased circulating angiotensin-(1-7) Peptides. 2012;37:247-51. doi: 10.1016/j.peptides.2012.08.002.</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Silva A.R., Aguilar E.C., Alvarez-Leite J.I. et al. Mas receptor deficiency is associated with worsening of lipid profile and severe hepatic steatosis in ApoE-knockout mice. Am J Physiol Regul Integr Comp Physiol. 2013;305: R1323-1330. doi: 10.1152/ajpregu.00249.2013.</mixed-citation><mixed-citation xml:lang="en">Silva A.R., Aguilar E.C., Alvarez-Leite J.I. et al. Mas receptor deficiency is associated with worsening of lipid profile and severe hepatic steatosis in ApoE-knockout mice. Am J Physiol Regul Integr Comp Physiol. 2013;305: R1323-1330. doi: 10.1152/ajpregu.00249.2013.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Moreira de Macedo S., Guimaraes T.A., Feltenberger J.D., Sousa Santos S.H. The role of renin-angiotensin system modulation on treatment and prevention of liver diseases. Peptides. 2014; 62:189-96. doi: 10.1016/j.peptides.2014.10.005.</mixed-citation><mixed-citation xml:lang="en">Moreira de Macedo S., Guimaraes T.A., Feltenberger J.D., Sousa Santos S.H. The role of renin-angiotensin system modulation on treatment and prevention of liver diseases. Peptides. 2014; 62:189-96. doi: 10.1016/j.peptides.2014.10.005.</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Elhence H., Dodge J.L., Lee B.P. Association of Renin-Angiotensin System Inhibition With Liver-Related Events and Mortality in Compensated Cirrhosis. Clin Gastroenterol Hepatol. 2024 Feb;22(2):315-323.e17. doi: 10.1016/j.cgh.2023.07.009.</mixed-citation><mixed-citation xml:lang="en">Elhence H., Dodge J.L., Lee B.P. Association of Renin-Angiotensin System Inhibition With Liver-Related Events and Mortality in Compensated Cirrhosis. Clin Gastroenterol Hepatol. 2024 Feb;22(2):315-323.e17. doi: 10.1016/j.cgh.2023.07.009.</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Goh G.B., Pagadala M.R., Dasarathy J. et al. Renin-angiotensin system and fibrosis in non-alcoholic fatty liver disease. Liver Int. 2015 Mar;35(3):979-85. doi: 10.1111/liv.12611.</mixed-citation><mixed-citation xml:lang="en">Goh G.B., Pagadala M.R., Dasarathy J. et al. Renin-angiotensin system and fibrosis in non-alcoholic fatty liver disease. Liver Int. 2015 Mar;35(3):979-85. doi: 10.1111/liv.12611.</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Mamedov M.N., Drapkina O.M. Choice of antihypertensive therapy in patients with arterial hypertension and chronic liver diseases. Rational Pharmacotherapyin Cardiology. 2008;4(4):65-68. (In Russ.) doi: 10.20996/ 1819-6446-2008-4-4-65-68.@@ Мамедов М.Н., Драпкина О.М. Выбор антигипертензивной терапии у больных с артериальной гипертонией и хроническими заболеваниями печени. Рациональная Фармакотерапия в Кардиологии. 2008;4(4):65-68. doi: 10.20996/1819-6446-2008-4-4-65-68.</mixed-citation><mixed-citation xml:lang="en">Mamedov M.N., Drapkina O.M. Choice of antihypertensive therapy in patients with arterial hypertension and chronic liver diseases. Rational Pharmacotherapyin Cardiology. 2008;4(4):65-68. (In Russ.) doi: 10.20996/ 1819-6446-2008-4-4-65-68.@@ Мамедов М.Н., Драпкина О.М. Выбор антигипертензивной терапии у больных с артериальной гипертонией и хроническими заболеваниями печени. Рациональная Фармакотерапия в Кардиологии. 2008;4(4):65-68. doi: 10.20996/1819-6446-2008-4-4-65-68.</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Lazebnik L.B., Komissarenko I.A., Levchenko S.V. et al. SV Effect of angiotensin-converting enzyme inhibitors on renal and hepatic function in patients with arterial hypertension of older age groups. Liki Ukrainy. 2012;(1): 36-42. (In Russ.)@@ Лазебник Л.Б., Комиссаренко И.А., Левченко С.В. и др. Влияние ингибиторов ангиотензинпревращающего фермента на функцию почек и печени у больных артериальной гипертензией старших возрастных групп. Ліки України. 2012;(1): 36-42.</mixed-citation><mixed-citation xml:lang="en">Lazebnik L.B., Komissarenko I.A., Levchenko S.V. et al. SV Effect of angiotensin-converting enzyme inhibitors on renal and hepatic function in patients with arterial hypertension of older age groups. Liki Ukrainy. 2012;(1): 36-42. (In Russ.)@@ Лазебник Л.Б., Комиссаренко И.А., Левченко С.В. и др. Влияние ингибиторов ангиотензинпревращающего фермента на функцию почек и печени у больных артериальной гипертензией старших возрастных групп. Ліки України. 2012;(1): 36-42.</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">Paschos P., Tziomalos K. Nonalcoholic fatty liver disease and the renin-angiotensin system: Implications for treatment. World J Hepatol. 2012;4:327-31. doi: 10.4254/wjh.v4.i12.327.</mixed-citation><mixed-citation xml:lang="en">Paschos P., Tziomalos K. Nonalcoholic fatty liver disease and the renin-angiotensin system: Implications for treatment. World J Hepatol. 2012;4:327-31. doi: 10.4254/wjh.v4.i12.327.</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">Вaran B., Akyuz F. Non-alcoholic fatty liver disease: what has changed in the treatment since the beginning? World J Gastroenterol. 2014;20:14219-29. doi: 10.3748/wjg.v20.i39.14219.</mixed-citation><mixed-citation xml:lang="en">Вaran B., Akyuz F. Non-alcoholic fatty liver disease: what has changed in the treatment since the beginning? World J Gastroenterol. 2014;20:14219-29. doi: 10.3748/wjg.v20.i39.14219.</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">Yokohama S., Tokusashi Y., Nakamura K. et al.Inhibitory effect of angiotensin II receptor antagonist on hepatic stellate cell activation in non-alcoholic steatohepatitis. World J Gastroenterol. 2006;12:322-6. doi: 10.3748/wjg.v12.i2.322.</mixed-citation><mixed-citation xml:lang="en">Yokohama S., Tokusashi Y., Nakamura K. et al.Inhibitory effect of angiotensin II receptor antagonist on hepatic stellate cell activation in non-alcoholic steatohepatitis. World J Gastroenterol. 2006;12:322-6. doi: 10.3748/wjg.v12.i2.322.</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">Yokohama S., Yoneda M., Haneda M. et al. Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis. Hepatology. 2004;40:1222-5. doi: 10.1002/hep.20420.</mixed-citation><mixed-citation xml:lang="en">Yokohama S., Yoneda M., Haneda M. et al. Therapeutic efficacy of an angiotensin II receptor antagonist in patients with nonalcoholic steatohepatitis. Hepatology. 2004;40:1222-5. doi: 10.1002/hep.20420.</mixed-citation></citation-alternatives></ref><ref id="cit86"><label>86</label><citation-alternatives><mixed-citation xml:lang="ru">Meng C., Song Z., Zhang L. et al. Effects of losartan in patients with NAFLD: A meta-analysis of randomized controlled trial. Open Life Sci. 2023;18(1):20220583. doi: 10.1515/biol-2022-0583.</mixed-citation><mixed-citation xml:lang="en">Meng C., Song Z., Zhang L. et al. Effects of losartan in patients with NAFLD: A meta-analysis of randomized controlled trial. Open Life Sci. 2023;18(1):20220583. doi: 10.1515/biol-2022-0583.</mixed-citation></citation-alternatives></ref><ref id="cit87"><label>87</label><citation-alternatives><mixed-citation xml:lang="ru">Hirata Т., Tomita K., Kawai T. et al. Effect of Telmisartan or Losartan for Treatment of Nonalcoholic Fatty Liver Disease: Fatty Liver Protection Trial by Telmisartan or Losartan Study (FANTASY).Int J Endocrinol. 2013; 587140. doi: 10.1155/2013/587140.</mixed-citation><mixed-citation xml:lang="en">Hirata Т., Tomita K., Kawai T. et al. Effect of Telmisartan or Losartan for Treatment of Nonalcoholic Fatty Liver Disease: Fatty Liver Protection Trial by Telmisartan or Losartan Study (FANTASY).Int J Endocrinol. 2013; 587140. doi: 10.1155/2013/587140.</mixed-citation></citation-alternatives></ref><ref id="cit88"><label>88</label><citation-alternatives><mixed-citation xml:lang="ru">Hirata Т., Tomita K., Kawai T. et al. Effect of Telmisartan or Losartan for Treatment of Nonalcoholic Fatty Liver Disease: Fatty Liver Protection Trial by Telmisartan or Losartan Study (FANTASY).Int J Endocrinol. 2013; 587140. doi: 10.1155/2013/587140.</mixed-citation><mixed-citation xml:lang="en">Hirata Т., Tomita K., Kawai T. et al. Effect of Telmisartan or Losartan for Treatment of Nonalcoholic Fatty Liver Disease: Fatty Liver Protection Trial by Telmisartan or Losartan Study (FANTASY).Int J Endocrinol. 2013; 587140. doi: 10.1155/2013/587140.</mixed-citation></citation-alternatives></ref><ref id="cit89"><label>89</label><citation-alternatives><mixed-citation xml:lang="ru">Borém L.M.A., Neto J.F.R., Brandi I.V. et al. The role of the angiotensin II type I receptor blocker telmisartan in the treatment of non-alcoholic fatty liver disease: a brief review. Hypertens Res. 2018 Jun;41(6):394-405. doi: 10.1038/s41440-018-0040-6.</mixed-citation><mixed-citation xml:lang="en">Borém L.M.A., Neto J.F.R., Brandi I.V. et al. The role of the angiotensin II type I receptor blocker telmisartan in the treatment of non-alcoholic fatty liver disease: a brief review. Hypertens Res. 2018 Jun;41(6):394-405. doi: 10.1038/s41440-018-0040-6.</mixed-citation></citation-alternatives></ref><ref id="cit90"><label>90</label><citation-alternatives><mixed-citation xml:lang="ru">Park H.W., Lee J.H. Calcium channel blockers as potential therapeutics for obesity-associated autophagy defects and fatty liver pathologies. Autophagy. 2014;10(12):2385-6. doi: 10.4161/15548627.2014.984268.</mixed-citation><mixed-citation xml:lang="en">Park H.W., Lee J.H. Calcium channel blockers as potential therapeutics for obesity-associated autophagy defects and fatty liver pathologies. Autophagy. 2014;10(12):2385-6. doi: 10.4161/15548627.2014.984268.</mixed-citation></citation-alternatives></ref><ref id="cit91"><label>91</label><citation-alternatives><mixed-citation xml:lang="ru">Li Y., Zhao D., Qian M. et al. Amlodipine, an anti-hypertensive drug, alleviates non-alcoholic fatty liver disease by modulating gut microbiota. Br J Pharmacol. 2022 May;179(9):2054-2077. doi: 10.1111/bph.15768.</mixed-citation><mixed-citation xml:lang="en">Li Y., Zhao D., Qian M. et al. Amlodipine, an anti-hypertensive drug, alleviates non-alcoholic fatty liver disease by modulating gut microbiota. Br J Pharmacol. 2022 May;179(9):2054-2077. doi: 10.1111/bph.15768.</mixed-citation></citation-alternatives></ref><ref id="cit92"><label>92</label><citation-alternatives><mixed-citation xml:lang="ru">Drapkina O.M., Korneeva O.N. Diroton in the treatment of arterial hypertension in patients with metabolic syndrome and non-alcoholic fatty liver disease (the CONDUCTOR study).Russian Medical News. 2013:18(3):41-9. (In Russ.)@@ Драпкина О.М., Корнеева О.Н. Диротон в лечении артериальной гипертензии у пациентов с метаболическим синдромом и неалкогольной жировой болезнью печени (исследование «ДИРИЖЕР»). Российские Медицинские Вести. 2013:18(3):41-9.</mixed-citation><mixed-citation xml:lang="en">Drapkina O.M., Korneeva O.N. Diroton in the treatment of arterial hypertension in patients with metabolic syndrome and non-alcoholic fatty liver disease (the CONDUCTOR study).Russian Medical News. 2013:18(3):41-9. (In Russ.)@@ Драпкина О.М., Корнеева О.Н. Диротон в лечении артериальной гипертензии у пациентов с метаболическим синдромом и неалкогольной жировой болезнью печени (исследование «ДИРИЖЕР»). Российские Медицинские Вести. 2013:18(3):41-9.</mixed-citation></citation-alternatives></ref><ref id="cit93"><label>93</label><citation-alternatives><mixed-citation xml:lang="ru">Liu Y., Boettcher M.F., Schmidt A. et al. Pharmacokinetics and safety of nifedipine GITS/candesartan fixed-dose combination in subjects with hepatic impairment.Int J Clin Pharmacol Ther. 2017 Mar;55(3):246-255. doi: 10.5414/CP202700. PMID: 28025965.</mixed-citation><mixed-citation xml:lang="en">Liu Y., Boettcher M.F., Schmidt A. et al. Pharmacokinetics and safety of nifedipine GITS/candesartan fixed-dose combination in subjects with hepatic impairment.Int J Clin Pharmacol Ther. 2017 Mar;55(3):246-255. doi: 10.5414/CP202700. PMID: 28025965.</mixed-citation></citation-alternatives></ref><ref id="cit94"><label>94</label><citation-alternatives><mixed-citation xml:lang="ru">Hassankhan B., Yaghmaei P., Parivar K., Ebrahim-Habibi A. Effect of Beta-adrenergic blockade in High-fatinduced nonalcoholic fatty liver disease. Arch Pharma Pract. 2020;11(2):87-95.</mixed-citation><mixed-citation xml:lang="en">Hassankhan B., Yaghmaei P., Parivar K., Ebrahim-Habibi A. Effect of Beta-adrenergic blockade in High-fatinduced nonalcoholic fatty liver disease. Arch Pharma Pract. 2020;11(2):87-95.</mixed-citation></citation-alternatives></ref><ref id="cit95"><label>95</label><citation-alternatives><mixed-citation xml:lang="ru">Albillos A., Krag A. Beta-blockers in the era of precision medicine in patients with cirrhosis. J Hepatol. 2023;78(4):866-872. doi: 10.1016/j.jhep.2022.12.005.</mixed-citation><mixed-citation xml:lang="en">Albillos A., Krag A. Beta-blockers in the era of precision medicine in patients with cirrhosis. J Hepatol. 2023;78(4):866-872. doi: 10.1016/j.jhep.2022.12.005.</mixed-citation></citation-alternatives></ref><ref id="cit96"><label>96</label><citation-alternatives><mixed-citation xml:lang="ru">European Association for the Study of the Liver. EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis. J Hepatol. 2018;69(2):406-460. doi: 10.1016/j.jhep.2018.03.024. Erratum in: J Hepatol. 2018;69(5):1207. doi: 10.1016/j.jhep.2018.08.00.</mixed-citation><mixed-citation xml:lang="en">European Association for the Study of the Liver. EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis. J Hepatol. 2018;69(2):406-460. doi: 10.1016/j.jhep.2018.03.024. Erratum in: J Hepatol. 2018;69(5):1207. doi: 10.1016/j.jhep.2018.08.00.</mixed-citation></citation-alternatives></ref><ref id="cit97"><label>97</label><citation-alternatives><mixed-citation xml:lang="ru">Ivashkin V.T., Maevskaya M.V., Zharkova M.S. et al. Clinical Recommendations of the Russian Scientific Liver Society and Russian Gastroenterological Association on Diagnosis and Treatment of Liver Fibrosis, Cirrhosis and Their Complications.Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2021;31(6):56-102. (In Russ.) doi: 10.22416/1382-4376-2021-31-6-56-102.@@ Ивашкин В.Т., Маевская М.В., Жаркова М.С. и др. Клинические рекомендации Российского общества по изучению печени и Российской гастроэнтерологической ассоциации по диагностике и лечению фиброза и цирроза печени и их осложнений. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2021;31(6):56-102. doi: 10.22416/1382-4376-2021-31-6-56-102.</mixed-citation><mixed-citation xml:lang="en">Ivashkin V.T., Maevskaya M.V., Zharkova M.S. et al. Clinical Recommendations of the Russian Scientific Liver Society and Russian Gastroenterological Association on Diagnosis and Treatment of Liver Fibrosis, Cirrhosis and Their Complications.Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2021;31(6):56-102. (In Russ.) doi: 10.22416/1382-4376-2021-31-6-56-102.@@ Ивашкин В.Т., Маевская М.В., Жаркова М.С. и др. Клинические рекомендации Российского общества по изучению печени и Российской гастроэнтерологической ассоциации по диагностике и лечению фиброза и цирроза печени и их осложнений. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2021;31(6):56-102. doi: 10.22416/1382-4376-2021-31-6-56-102.</mixed-citation></citation-alternatives></ref><ref id="cit98"><label>98</label><citation-alternatives><mixed-citation xml:lang="ru">Statsenko M.E., Streltsova A.M. Metabolic effects of combination therapy with ramipril and indapamide in patients with arterial hypertension and non-alcoholic fatty liver disease. Arterial hypertension. 2021;27(4):472-481. (In Russ.) doi: 10.18705/1607-419X-2021-27-4-472-481.@@ Стаценко М.Е., Стрельцова А.М. Метаболические эффекты комбинированной терапии рамиприлом и индапамидом у пациентов с артериальной гипертензией и неалкогольной жировой болезнью печени. Артериальная гипертензия. 2021;27(4):472-481. doi: 10.18705/1607-419X-2021-27-4-472-481.</mixed-citation><mixed-citation xml:lang="en">Statsenko M.E., Streltsova A.M. Metabolic effects of combination therapy with ramipril and indapamide in patients with arterial hypertension and non-alcoholic fatty liver disease. Arterial hypertension. 2021;27(4):472-481. (In Russ.) doi: 10.18705/1607-419X-2021-27-4-472-481.@@ Стаценко М.Е., Стрельцова А.М. Метаболические эффекты комбинированной терапии рамиприлом и индапамидом у пациентов с артериальной гипертензией и неалкогольной жировой болезнью печени. Артериальная гипертензия. 2021;27(4):472-481. doi: 10.18705/1607-419X-2021-27-4-472-481.</mixed-citation></citation-alternatives></ref><ref id="cit99"><label>99</label><citation-alternatives><mixed-citation xml:lang="ru">Statsenko M.E., Streltsova A.M., Turovets M.I. The impact of non-alcoholic fatty liver disease on arterial stiffness indices and the risk of cardiovascular complications in patients with arterial hypertension. Archives of Internal Medicine. 2020;10(4):296-304.(In Russ.) doi: 10.20514/2226-6704-2020-10-4-296-304.@@ Стаценко М.Е., Стрельцова А.М., Туровец М.И. Влияние неалкогольной жировой болезни печени на показатели артериальной жесткости и риск сердечно-сосудистых осложнений у пациентов с артериальной гипертензией. Архивъ внутренней медицины. 2020;10(4):296-304. doi: 10.20514/2226-6704-2020-10-4-296-304.</mixed-citation><mixed-citation xml:lang="en">Statsenko M.E., Streltsova A.M., Turovets M.I. The impact of non-alcoholic fatty liver disease on arterial stiffness indices and the risk of cardiovascular complications in patients with arterial hypertension. Archives of Internal Medicine. 2020;10(4):296-304.(In Russ.) doi: 10.20514/2226-6704-2020-10-4-296-304.@@ Стаценко М.Е., Стрельцова А.М., Туровец М.И. Влияние неалкогольной жировой болезни печени на показатели артериальной жесткости и риск сердечно-сосудистых осложнений у пациентов с артериальной гипертензией. Архивъ внутренней медицины. 2020;10(4):296-304. doi: 10.20514/2226-6704-2020-10-4-296-304.</mixed-citation></citation-alternatives></ref><ref id="cit100"><label>100</label><citation-alternatives><mixed-citation xml:lang="ru">Efremova O.A., Chernobay P.E., Pogurelskaya E.P. Experience of using telmisartan, atorvastatin and ursodeoxycholic acid in patients with arterial hypertension in combination with non-alcoholic fatty liver disease. Siberian Scientific Medical Journal. 2021;41(5):75-82. (In Russ.) doi: 10.18699/SSMJ20210510.@@ Ефремова О.А., Чернобай П.Е., Погурельская Е.П. Опыт применения телмисартана, аторвастатина и урсодезоксихолевой кислоты у больных артериальной гипертонией в сочетании с неалкогольной жировой болезнью печени. Сибирский научный медицинский журнал. 2021;41(5):75-82. doi: 10.18699/SSMJ20210510.</mixed-citation><mixed-citation xml:lang="en">Efremova O.A., Chernobay P.E., Pogurelskaya E.P. Experience of using telmisartan, atorvastatin and ursodeoxycholic acid in patients with arterial hypertension in combination with non-alcoholic fatty liver disease. Siberian Scientific Medical Journal. 2021;41(5):75-82. (In Russ.) doi: 10.18699/SSMJ20210510.@@ Ефремова О.А., Чернобай П.Е., Погурельская Е.П. Опыт применения телмисартана, аторвастатина и урсодезоксихолевой кислоты у больных артериальной гипертонией в сочетании с неалкогольной жировой болезнью печени. Сибирский научный медицинский журнал. 2021;41(5):75-82. doi: 10.18699/SSMJ20210510.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
