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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-231-11-128-136</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-2973</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Синдром раздраженного кишечника: неврологические аспекты патогенеза и терапии</article-title><trans-title-group xml:lang="en"><trans-title>Irritable bowel syndrome: neurological aspects of pathogenesis and therapy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0632-6653</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юсупов</surname><given-names>Ф. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Yusupov</surname><given-names>F. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4839-1306</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ыдырысов</surname><given-names>И. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Ydyrysov</surname><given-names>I. T.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4179-9205</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юлдашев</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Yuldashev</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">akmal.yuldashev.2017@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Ошский государственный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Osh State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>17</day><month>11</month><year>2024</year></pub-date><volume>0</volume><issue>11</issue><fpage>128</fpage><lpage>136</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Юсупов Ф.А., Ыдырысов И.Т., Юлдашев А.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Юсупов Ф.А., Ыдырысов И.Т., Юлдашев А.А.</copyright-holder><copyright-holder xml:lang="en">Yusupov F.A., Ydyrysov I.T., Yuldashev A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/2973">https://www.nogr.org/jour/article/view/2973</self-uri><abstract><p>Синдром раздраженного кишечника представляет собой хроническое рецидивирующее заболевание желудочно-кишечного тракта, характеризующееся болью в животе, вздутием живота и изменением характера стула. Хотя точная распространенность и заболеваемость зависят от используемых критериев, все исследования сходятся во мнении, что это распространенное заболевание, поражающее значительную часть населения в целом и часто обращающееся к врачам общей практики и к узким специалистам. Синдром раздраженного кишечника вызывает беспокойство, оказывая значительное негативное влияние на качество жизни и социальное функционирование многих пациентов. Синдром раздраженного кишечника является одним из наиболее часто диагностируемых заболеваний желудочно-кишечного тракта. Это представляет собой значительную нагрузку на здравоохранение и остается клинической проблемой. На протяжении многих лет синдром раздраженного кишечника описывали с разных точек зрения; от строгой болезни желудочно-кишечного тракта (медицинская модель) до более сложного полисиндромальные расстройства оси мозг-кишка (биопсихосоциальная/психосоматическая модель). Целью нашего обзора представить современные аспекты патофизиологии и лечении синдрома разждраженного кишечника.</p></abstract><trans-abstract xml:lang="en"><p>Irritable bowel syndrome is a chronic, relapsing gastrointestinal disorder characterized by abdominal pain, bloating, and changes in bowel habits. Although the exact prevalence and incidence depend on the criteria used, all studies agree that it is a common disease, affecting a large proportion of the general population and frequently presenting to general practitioners and specialists. Irritable bowel syndrome is a concern, having a significant negative impact on the quality of life and social functioning of many patients. Irritable bowel syndrome is one of the most commonly diagnosed gastrointestinal diseases. This represents a significant healthcare burden and remains a clinical problem. Irritable bowel syndrome has been described from different perspectives over the years; from strict gastrointestinal disease (medical model) to more complex polysyndromic disorders of the brain-gut axis (biopsychosocial/psychosomatic model). The purpose of our review is to present modern aspects of the pathophysiology and treatment of irritable bowel syndrome.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>синдром раздраженного кишечника</kwd><kwd>патогенез</kwd><kwd>ось мозг-кишечник</kwd><kwd>психосоматика</kwd><kwd>лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>irritable bowel syndrome</kwd><kwd>pathogenesis</kwd><kwd>brain-gut axis</kwd><kwd>psychosomatics</kwd><kwd>treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Yusupov F.A., Yuldashev A.A. Modern aspects of vagus-induced gastroprotection and ulcerogenesis in gastric and duodenal ulcers. 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