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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-233-1-137-142</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-2953</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Диагностика болезни Уиппла как спорадичекого инфекционного заболевания</article-title><trans-title-group xml:lang="en"><trans-title>Diagnosis of Whipple’s disease as a sporadic infectious disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горяинова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Goryainova</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">dr.goryainova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каширская</surname><given-names>Н. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kashirskaya</surname><given-names>N. Yu.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3586-3458</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зинченко</surname><given-names>Р. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zinchenko</surname><given-names>R. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7308-7280</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хавкин</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Khavkin</surname><given-names>A. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Госпиталь «MD Group Мичуринский»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>“MD Group hospital”</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное научное учреждение «Медико-генетический научный центр имени академика Н.П. Бочкова»; Государственное бюджетное учреждение здравоохранения Московской области «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Center for Medical Genetics; Moscow Region Research and Clinical Institute n. a. M.F. Vladimirskiy</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное научное учреждение «Медико-генетический научный центр имени академика Н.П. Бочкова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Center for Medical Genetics</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ГБУЗ МО «Научно-исследовательский клинический институт детства» Министерства здравоохранения Московской области; Федеральное государственное автономное образовательное учреждение высшего образования «Белгородский государственный исследовательский университет» Министерства науки и высшего образования Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region; Belgorod State Research University. Ministry of Science and Higher Education of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>17</day><month>01</month><year>2025</year></pub-date><volume>0</volume><issue>1</issue><fpage>137</fpage><lpage>142</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Горяинова А.В., Каширская Н.Ю., Зинченко Р.А., Хавкин А.И., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Горяинова А.В., Каширская Н.Ю., Зинченко Р.А., Хавкин А.И.</copyright-holder><copyright-holder xml:lang="en">Goryainova A.V., Kashirskaya N.Y., Zinchenko R.A., Khavkin A.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/2953">https://www.nogr.org/jour/article/view/2953</self-uri><abstract><p>Данная публикация посвящена достаточно поздней и сложной диагностике болезни Уиппла у взрослого пациента 37 лет, с 4х летним, медленно прогрессирующим формированием полиорганной недостаточности на фоне отсутствия корректной постановки диагноза, отсутствия назначения этиологически значимого лечения; при этом проходящего углубленные обследования в различных медицинских структурах в течение нескольких лет.</p></abstract><trans-abstract xml:lang="en"><p>This publication is devoted to a rather late and difficult diagnosis of Whipple’s disease in an adult patient of 37 years old, with a 4-year history of slowly progressive formation of multiorgan failure against the background of lack of correct diagnosis, lack of prescription of etiologically significant treatment; at the same time undergoing detailed examinations in various medical structures for several years.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>болезнь Уиппла</kwd><kwd>Tropheryma whipplei</kwd><kwd>кишечная вторичная лимфангиэктазия</kwd><kwd>синдром мальабсорбции тяжелой степени</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Whipple’s disease</kwd><kwd>Tropheryma whipplei</kwd><kwd>intestinal secondary lymphangiectasia</kwd><kwd>severe malabsorption syndrome</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Dolmans R.A., Boel C.H., Lacle M.M., Kusters J.G. 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